MIA_03137_1

Protein

Length

1,409 amino acids

Browser: contig04:316039-320331+

Protein function

EGGNOG:	0PGJZ	FG09515.1	P-type ATPase
SGD closest match:	S000002974	PMC1	Calcium-transporting ATPase 2
CGD closest match:	CAL0000196416	PMC1	Calcium-transporting ATPase

Protein alignments

	%id	Aln length
MCA_01046_1	67.021%	1222	MCA_01046_1
A0A0J9X5E9_GEOCN	59.799%	1194	Calcium-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA03s01000g PE=3 SV=1
A0A161HIQ6_9ASCO	55.830%	1175	Calcium-transporting ATPase OS=Sugiyamaella lignohabitans GN=PMC1 PE=3 SV=1
A0A1E3PSP3_9ASCO	56.714%	1065	Calcium-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81344 PE=3 SV=1
Q6CA91_YARLI	52.946%	1188	Calcium-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D04873g PE=3 SV=2
UniRef50_Q6CA91	52.946%	1188	Calcium-transporting ATPase n=7 Tax=saccharomyceta TaxID=716545 RepID=Q6CA91_YARLI
A0A060SWP2_BLAAD	54.027%	1192	Calcium-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A06798g PE=3 SV=1
A0A1E4TCJ4_9ASCO	50.326%	1073	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13458 PE=3 SV=1
Q5AJ65_CANAL	48.556%	1108	Calcium-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PMC1 PE=3 SV=1
ATC2_YEAST	46.379%	1091	Calcium-transporting ATPase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PMC1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0021

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IIB (IPR006408)

Domains and repeats

Domain
215 - 275
Cation-transporting P-type ATPase, N-terminal (IPR004014)
569 - 611
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
638 - 1,033
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
Domain
226 - 334
P-type ATPase, transmembrane domain (IPR023298)
335 - 453
P-type ATPase, A domain (IPR008250)
456 - 564
P-type ATPase, transmembrane domain (IPR023298)
976 - 1,190
P-type ATPase, transmembrane domain (IPR023298)
Domain
1,013 - 1,186
Cation-transporting P-type ATPase, C-terminal (IPR006068)

1 200 400 600 800 1000 1200 1409

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  893 - 1,009
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  457 - 590
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
2. PR00120 (HATPASE)
  
  775 - 793
  
  PRINTS
  PR00120 (HATPASE)
  
  958 - 983
  
  PRINTS
  PR00120 (HATPASE)
  
  926 - 942
  
  PRINTS
  PR00120 (HATPASE)
IPR006408

P-type ATPase, subfamily IIB
1. TIGR01517
  
  658 - 1,191
  
  TIGRFAMs
  TIGR01517 (TIGR01517)
IPR004014

Cation-transporting P-type ATPase, N-terminal
1. PF00690 (Cation_ATP...)
  
  227 - 270
  
  Pfam
  PF00690 (Cation_ATPase_N)
2. SM00831 (Cation_ATP...)
  
  215 - 275
  
  SMART
  SM00831 (Cation_ATPase_N_a_2)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  456 - 564
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  226 - 334
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  976 - 1,190
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  335 - 453
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  772 - 1,033
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  569 - 588
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  638 - 826
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
  
  577 - 611
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  641 - 818
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
  
  819 - 855
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR006068

Cation-transporting P-type ATPase, C-terminal
1. PF00689 (Cation_ATP...)
  
  1,013 - 1,186
  
  Pfam
  PF00689 (Cation_ATPase_C)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  572 - 578
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1,113 - 1,132

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,186 - 1,361

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 246

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

318 - 475

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

544 - 985

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,036 - 1,055

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

856 - 1,200

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)

254 - 599

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
NON_CYTOPLASM... (N...)

1,383 - 1,409

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

497 - 515

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,008 - 1,012

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

277 - 295

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,076 - 1,094

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,161 - 1,165

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

334 - 549

Pfam
PF00122 (E1-E2_ATPase)
PF13246 (Cation_ATPase)

659 - 758

Pfam
PF13246 (Cation_ATPase)
PR00119 (CATATPASE)

822 - 833

PRINTS
PR00119 (CATATPASE)

844 - 854

PRINTS
PR00119 (CATATPASE)

570 - 584

PRINTS
PR00119 (CATATPASE)

382 - 396

PRINTS
PR00119 (CATATPASE)

950 - 962

PRINTS
PR00119 (CATATPASE)

926 - 945

PRINTS
PR00119 (CATATPASE)
TMhelix

517 - 539

TMHMM
TMhelix (TMhelix)

259 - 280

TMHMM
TMhelix (TMhelix)

475 - 497

TMHMM
TMhelix (TMhelix)

1,095 - 1,117

TMHMM
TMhelix (TMhelix)

1,166 - 1,188

TMHMM
TMhelix (TMhelix)

1,064 - 1,083

TMHMM
TMhelix (TMhelix)

1,137 - 1,159

TMHMM
TMhelix (TMhelix)

295 - 317

TMHMM
TMhelix (TMhelix)

986 - 1,008

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,056 - 1,075

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,362 - 1,382

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,133 - 1,160

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,095 - 1,112

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,166 - 1,185

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

296 - 317

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

516 - 543

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,013 - 1,035

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

476 - 496

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

986 - 1,007

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

247 - 276

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02081 (P-type_ATP...)

227 - 1,061

CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
mobidb-lite (disord...)

1,387 - 1,409

MobiDB Lite
mobidb-lite (disorder_prediction)

130 - 213

MobiDB Lite
mobidb-lite (disorder_prediction)

1,288 - 1,360

MobiDB Lite
mobidb-lite (disorder_prediction)

600 - 643

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 56

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

phosphorylation si...

572D

phosphorylation site
572D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
P-type ATPase sign...

572D

P-type ATPase signature motif
572D, 573K, 574T, 575G, 576T, 577L, 578T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

573K

P-type ATPase signature motif
572D, 573K, 574T, 575G, 576T, 577L, 578T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

574T

P-type ATPase signature motif
572D, 573K, 574T, 575G, 576T, 577L, 578T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

575G

P-type ATPase signature motif
572D, 573K, 574T, 575G, 576T, 577L, 578T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

576T

P-type ATPase signature motif
572D, 573K, 574T, 575G, 576T, 577L, 578T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

577L

P-type ATPase signature motif
572D, 573K, 574T, 575G, 576T, 577L, 578T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

578T

P-type ATPase signature motif
572D, 573K, 574T, 575G, 576T, 577L, 578T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
putative ATP bindi...

572D

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

573K

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

574T

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

721F

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

745K

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

746G

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

747A

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

790I

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

852T

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

853G

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

854D

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

903R

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

906P

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

909K

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

928D

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

931N

putative ATP binding site
572D, 573K, 574T, 721F, 745K, 746G, 747A, 790I, 852T, 853G, 854D, 903R, 906P, 909K, 928D, 931N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
putative cation bi...

989F

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

993V

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

994N

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

996T

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

997A

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

1,024N

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

1,027M

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

1,028D

putative cation binding site
989F, 993V, 994N, 996T, 997A, 1,024N, 1,027M, 1,028D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

Protein sequence

>MIA_03137_1
MGSDQDSSNPKQRVKITVNPPIDAQNTSIIEYQDQPSSSSLPNTNNSLAPPRESSDCHSYNDFLHKAQHELDEEIIPNPL
QTSFGVSSQQLQLLHSLKDPYLLVALGGIHGLESKLQADLVKGLPYYHEPLDSESRRHSLNLPDSSPIEQNHTNKASSQH
HETLPSNDAGPSFYSPNTNTLIDSTPISPQPQTYTQPQRKSFSSDRRSSTMSIRQQHMLSATENPDYQNRLSYFGSNKLP
EKKPKSFFALVWLALQDKVLILLSIAAAISLAIGLYETFGQPPDYDEDGNPKPRVEWVEGVAIIAAIAIVSLVGAANDWQ
KERQFVKLNKKKEDRMVRVTRGGHTTEISIFDIVVGDLVQIEPGDVVPCDGILLSGYSVKCDESSLTGESETVKKLPALE
VLDKLNAHQGDDALNPRSKGLDFFIISGSRVLEGTGEFVATAVGTNSFYGKTMMSLNTEAEETPLQQKLNIIAEGIAKLG
TLAAATMFVVLFIRFLAQLPTSPKTGSEKGEEFMNILITAITIIVVAVPEGLPLAVTLALAFATTRMIKDNNLVRVLKAC
ETMGGATAVCSDKTGTLTQNRMTVVAGTLGLESNFELVTDESKTGEQSEQDEQSQDASSQTFTDAPTLSLTPPPVDAPSP
SQFVSQLSPKALDLLLSSIAVNTSAFENLSYEEEIQASQPSDRYIGSKTETAILTFAYNYLNMGPLDEARSQYSVARVYP
FDSSKKYMATVIELPNRSGYRLFIKGASEVMLAACTSVFDHDHVRPISSSEKDSIKARIDAYASESLRAIGFVYRDFDWS
PSWPPKDFDDEESLLTNMTFLSVVGIKDPLRPGVRKAVADCHSAGVVVRMVTGDNIITARAIARDCGIYDEGSDQIVMEG
PVFRKKSDDELYRIAPKLRVLARSSPDDKRRLVKILKDMGETVAVTGDGTNDAPALKLADVGFSMGISGTEVAREASEII
LMDDNFGSIVKAIIWGRTVNDAVKKFLQFQLTVNITAVILTFVSAVASSENESVLTAVQLLWVNLIMDTFAALALATDPP
DPNVLYRKPDDRKASLITPTMWKIIIGEAIYQLIVSFTLNFAGNSIFHAHTGKEIVRVHSLVFNTFVWMQFFKMFVARRL
DNKLNMFEGLSKNYYYIAISSIICGAQVIIMFFGGAAFNIERQTPAMWAVALLCGFGSIPVGLFLRCIPDEFLIRHFPTR
FFHFLGRVYEKCKFWRYFSKNKQTSPAIRIQDDDEARVDSMPHYIWPAPLEQVRQELMFLKLRGGRWNQIKTKPKEFIHN
VYKSLTPADPSSPHLSESSTLHSPLSAIPPLDELPAPADSEGFLQVPGAHHTANGNAGGGSGLSSPNGNRSRSRKSSTSS
GYSIEALAMVPSFVGGAIAGWGPELDRNSSSTLHRTTSATPLVQPEDRL

GO term prediction

Biological Process

GO:0070588 calcium ion transmembrane transport

Molecular Function

GO:0000166 nucleotide binding
GO:0005388 calcium-transporting ATPase activity
GO:0005524 ATP binding

Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features