MCA_01046_1

Protein

Length

1,346 amino acids

Gene name: PMC1

Description: Calcium-transporting ATPase 2

Browser: contigA:3342067-3346173+

RNA-seq: read pairs 14959, FPKM 137.2, percentile rank 83.8% (100% = highest expression)

Protein function

Annotation:		PMC1	Calcium-transporting ATPase 2
KEGG:	K01537	E3.6.3.8	Ca2+-transporting ATPase [EC:3.6.3.8]
EGGNOG:	0PGJZ	FG09515.1	P-type ATPase
SGD closest match:	S000002974	PMC1	Calcium-transporting ATPase 2
CGD closest match:	CAL0000196416	PMC1	Calcium-transporting ATPase

Protein alignments

	%id	Aln length
MIA_03137_1	66.07%	1232	MIA_03137_1
A0A0J9X5E9_GEOCN	56.97%	1292	Calcium-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA03s01000g PE=3 SV=1
A0A161HIQ6_9ASCO	54.70%	1170	Calcium-transporting ATPase OS=Sugiyamaella lignohabitans GN=PMC1 PE=3 SV=1
A0A1E3PSP3_9ASCO	55.44%	1102	Calcium-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81344 PE=3 SV=1
UniRef50_A0A1E3PJ55	52.76%	1158	Calcium-transporting ATPase n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PJ55_9ASCO
A0A060SWP2_BLAAD	50.44%	1356	Calcium-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A06798g PE=3 SV=1
A0A1E4TCJ4_9ASCO	49.68%	1105	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13458 PE=3 SV=1
Q5AJ65_CANAL	46.44%	1180	Calcium-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PMC1 PE=3 SV=1
ATC2_YEAST	46.40%	1112	Calcium-transporting ATPase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PMC1 PE=1 SV=1
Q6CA91_YARLI	52.86%	647	Calcium-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D04873g PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0031

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IIB (IPR006408)

Domains and repeats

Domain
126 - 233
P-type ATPase, transmembrane domain (IPR023298)
362 - 470
P-type ATPase, transmembrane domain (IPR023298)
907 - 1,123
P-type ATPase, transmembrane domain (IPR023298)
Domain
127 - 169
Cation-transporting P-type ATPase, N-terminal (IPR004014)
475 - 498
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
524 - 964
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
Domain
234 - 358
P-type ATPase, A domain (IPR008250)
944 - 1,117
Cation-transporting P-type ATPase, C-terminal (IPR006068)

1 200 400 600 800 1000 1200 1346

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  826 - 945
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  411 - 494
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
2. PR00120 (HATPASE)
  
  707 - 725
  
  PRINTS
  PR00120 (HATPASE)
  
  857 - 873
  
  PRINTS
  PR00120 (HATPASE)
  
  889 - 914
  
  PRINTS
  PR00120 (HATPASE)
IPR006408

P-type ATPase, subfamily IIB
1. TIGR01517
  
  579 - 1,121
  
  TIGRFAMs
  TIGR01517 (TIGR01517)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  362 - 470
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  907 - 1,123
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  126 - 233
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR004014

Cation-transporting P-type ATPase, N-terminal
1. PF00690 (Cation_ATP...)
  
  127 - 169
  
  Pfam
  PF00690 (Cation_ATPase_N)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  234 - 358
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  704 - 964
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  475 - 494
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  578 - 766
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
  
  482 - 498
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  524 - 759
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR006068

Cation-transporting P-type ATPase, C-terminal
1. PF00689 (Cation_ATP...)
  
  944 - 1,117
  
  Pfam
  PF00689 (Cation_ATPase_C)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  478 - 484
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

215 - 381

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 157

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,117 - 1,346

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

450 - 916

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,044 - 1,063

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

971 - 990

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

763 - 1,121

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)

153 - 505

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
NON_CYTOPLASM... (N...)

177 - 195

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,092 - 1,096

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

939 - 949

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,015 - 1,025

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

403 - 421

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

233 - 455

Pfam
PF00122 (E1-E2_ATPase)
PF13246 (Cation_ATPase)

588 - 686

Pfam
PF13246 (Cation_ATPase)
PR00119 (CATATPASE)

776 - 786

PRINTS
PR00119 (CATATPASE)

476 - 490

PRINTS
PR00119 (CATATPASE)

881 - 893

PRINTS
PR00119 (CATATPASE)

754 - 765

PRINTS
PR00119 (CATATPASE)

281 - 295

PRINTS
PR00119 (CATATPASE)

857 - 876

PRINTS
PR00119 (CATATPASE)
TMhelix

1,026 - 1,048

TMHMM
TMhelix (TMhelix)

917 - 939

TMHMM
TMhelix (TMhelix)

423 - 445

TMHMM
TMhelix (TMhelix)

381 - 403

TMHMM
TMhelix (TMhelix)

1,065 - 1,087

TMHMM
TMhelix (TMhelix)

1,097 - 1,119

TMHMM
TMhelix (TMhelix)

158 - 179

TMHMM
TMhelix (TMhelix)

944 - 966

TMHMM
TMhelix (TMhelix)

194 - 216

TMHMM
TMhelix (TMhelix)

987 - 1,006

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

950 - 970

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

158 - 176

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

991 - 1,014

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

422 - 449

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

917 - 938

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,097 - 1,116

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,026 - 1,043

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,064 - 1,091

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

382 - 402

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

196 - 214

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02081 (P-type_ATP...)

129 - 992

CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
mobidb-lite (disord...)

91 - 124

MobiDB Lite
mobidb-lite (disorder_prediction)

1,327 - 1,346

MobiDB Lite
mobidb-lite (disorder_prediction)

1,208 - 1,307

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

phosphorylation si...

478D

phosphorylation site
478D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
P-type ATPase sign...

478D

P-type ATPase signature motif
478D, 479K, 480T, 481G, 482T, 483L, 484T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

479K

P-type ATPase signature motif
478D, 479K, 480T, 481G, 482T, 483L, 484T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

480T

P-type ATPase signature motif
478D, 479K, 480T, 481G, 482T, 483L, 484T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

481G

P-type ATPase signature motif
478D, 479K, 480T, 481G, 482T, 483L, 484T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

482T

P-type ATPase signature motif
478D, 479K, 480T, 481G, 482T, 483L, 484T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

483L

P-type ATPase signature motif
478D, 479K, 480T, 481G, 482T, 483L, 484T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

484T

P-type ATPase signature motif
478D, 479K, 480T, 481G, 482T, 483L, 484T
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
putative ATP bindi...

478D

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

479K

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

480T

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

650F

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

675K

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

676G

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

677A

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

722I

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

784T

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

785G

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

786D

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

834R

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

837P

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

840K

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

859D

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

862N

putative ATP binding site
478D, 479K, 480T, 650F, 675K, 676G, 677A, 722I, 784T, 785G, 786D, 834R, 837P, 840K, 859D, 862N
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)
putative cation bi...

920F

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

924V

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

925N

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

927T

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

928A

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

955N

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

958M

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

959D

putative cation binding site
920F, 924V, 925N, 927T, 928A, 955N, 958M, 959D
CDD
cd02081 (P-type_ATPase_Ca_PMCA-like)

Protein sequence

>MCA_01046_1
MGNPKDAPELTITTTNVSSQPISFEQPRKKTSFSNVDYYKAAEDNFNLQPHVDKNETEFDLSLEQIQLLGFERDPYLLYT
VGGPKGLEQKLDTNLSSGLPYNHNNSGEDSASIQPVSDPNSHHPSFKARQDYYGINRLPEKKPKSFLQLVWIALQDKVLI
LLSVVAVISLAIGLYQTFGQPPEYDENGNEKPHVEWVEGVAIIVAIAIVSLVGAGNDWQKERQFVKLNKKKEDRSVRVIR
GGHTIEISIFDIVVGDIVQLEPGDIVPCDGLLVHGYGIKADESSITGESDTIKKKIAADVYDLLCDQKKRLDSGEILTQL
DPHDKKLNCFIISGSKILEGTGEFLVTGVGQNSTYGKTILSLQTDPEETPLQVKLNIIAEGIAKLGTLAAFIMFVVLFIR
FLAQLPGSTKTGSQKGEEFLNILITAITIIVVAVPEGLPLAVTLALAFATTRMIKDNNLVRVLKACETMGGATAVCSDKT
GTLTQNKMTVVTGTAGISSKFELVTDASSHDDEDVMFAPKKQKQHEHHKNFLHLPKFMQSENHDANNDQTMAAEPTTTAV
VKASDAPTPEEFISSLEPSVKENLLASIVANTSAFENLNYEDEIKDNQSSERYVGSKTETALLSFAYNFMDMGNLEQCRQ
RYSIARVYPFDSAKKYMATVIKIPGSESGFRLLVKGASEVMVSACNRKVDPSTGKAEIMSSEDITFLNDRIVQYASQSLR
AIGMIYKDFPDDTEWPPQTFDESKILSNDFTFLGIVGIKDPLRHGVRKAVYDCKRAGVTVRMVTGDNVVTATAISKDCGI
LENEDQLVLEGPVFRKKTKSELYGIVPKLRVLARSSPDDKRLLVEVLKDMGETVAVTGDGTNDAPALKLADVGFSMGISG
TEVAKEASEIILMDDNFGSIVKAIVWGRTVNDAVKKFLQFQLTVNITAVILTFVSAVASSSNESVLTAVQLLWVNLIMDT
FAALALATDPPTLSVLERKPDDRKALLITPIMWKIIIGEAIYQLIVSFVLNFAGNDIFDAKTGKEIVQVHSLVFNTFVWM
QYFKMFVARRLDNKLNMFEGIFKNWYYIVISTIICGAQVLIMFFGGAAFNIVRQTPAQWGVAILCGFGSIPVGILLRCIP
DAFLAKIFPSSLFRFIGRVYEKCKFWKWFKKTSDEDDEYISSGSPKIRVFDEESRVGQPQYVWPEPLEQVRQDLIILKLR
GGRWNQIKQKPKQIMQQVRKSFSTSGSTTSVNNLSSSATTLNSPFSPPSPVDGHSLQLPNDNTHASNTNPNIDDSGFLSV
PNNGGSNNNSSSRNPFARSRGNSTSSKHSIDALAMVPTIVGGAIAGWGSPVPSSSSTTNLVDHNGN

GO term prediction

Biological Process

GO:0070588 calcium ion transmembrane transport

Molecular Function

GO:0000166 nucleotide binding
GO:0005388 calcium-transporting ATPase activity
GO:0005524 ATP binding

Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features