Protein

MIA_03133_1

Length
252 amino acids

Browser: contig04:311113-311985-

Protein function

EGGNOG:0PFMYPRE6The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
SGD closest match:S000005398PRE6Proteasome subunit alpha type-4
CGD closest match:CAL0000200321PRE6Proteasome endopeptidase complex

Protein alignments

%idAln lengthE-value
MCA_03864_188.889%2527.37e-156MCA_03864_1
A0A0J9XHP7_GEOCN84.348%2306.41e-146Proteasome endopeptidase complex OS=Geotrichum candidum GN=BN980_GECA17s01066g PE=3 SV=1
A0A1E3PI86_9ASCO77.391%2302.44e-136Proteasome endopeptidase complex OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46802 PE=3 SV=1
A0A060TEC2_BLAAD76.957%2301.72e-133Proteasome endopeptidase complex OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D05918g PE=3 SV=1
A0A1E4T9Q6_9ASCO73.913%2303.24e-132Proteasome endopeptidase complex OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_146450 PE=3 SV=1
Q6CEN6_YARLI74.783%2302.27e-130Proteasome endopeptidase complex OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B14267g PE=3 SV=1
A0A167EJ58_9ASCO74.153%2361.72e-129Proteasome endopeptidase complex OS=Sugiyamaella lignohabitans GN=PRE6 PE=3 SV=1
A0A1D8PSS4_CANAL73.043%2302.52e-128Proteasome endopeptidase complex OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRE6 PE=3 SV=1
PSA4_YEAST69.658%2342.75e-125Proteasome subunit alpha type-4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRE6 PE=1 SV=1
UniRef50_P4030369.658%2346.59e-122Proteasome subunit alpha type-4 n=197 Tax=Eukaryota TaxID=2759 RepID=PSA4_YEAST

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0374

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 252

Detailed signature matches

  1. Family IPR001353
    Proteasome, subunit alpha/beta
    1. PF00227 (Proteasome)
  2. Family IPR023332
    Proteasome alpha-type subunit
    1. PS51475 (PROTEASOME...)
  3. Domain IPR029055
    Nucleophile aminohydrolases, N-terminal
    1. G3DSA:3.60.20.10
    2. SSF56235 (N-termina...)
  4. Domain IPR000426
    Proteasome alpha-subunit, N-terminal domain
    1. PS00388 (PROTEASOME...)
    2. PF10584 (Proteasome...)
    3. SM00948 (Proteasome...)
  5. SITE IPR016050
    Proteasome beta-type subunit, conserved site
    1. PS00854 (PROTEASOME...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd03755 (proteasome...)

Residue annotation

  1. alpha subunit inte...
  2. active site cd03755

Protein sequence

>MIA_03133_1
MSGYDRALSVFSPDGHVFQVEYALEAVKRGTCAVAVKGGEAVIVGCEKRSALKLQDTRTTPSKINQLDDHIYLAFAGLNA
DARILIDKARVEAQSRKLTVEDPATVEYMTKYIAGVQQRYTQSGGVRPFGVSTIVVGFDPNDSTPQLYLTEPSGIYSAWK
ANAIGRNSKTVRELLEKSYEPDLSTEATIKLAVKSLLEVVQTGAKNIEIMVLEPGKKARTLDADSLSTYVTEIEAEKEAE
AAAKKHTRSSQQ

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex