Protein

MIA_03131_1

Length
371 amino acids

Browser: contig04:307137-308253+

Protein function

EGGNOG:0PJGDTEP1phosphatase
SGD closest match:S000005072TEP1Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
CGD closest match:CAL0000179965TEP1Putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Protein alignments

%idAln lengthE-value
MCA_04954_166.482%3615.95e-178MCA_04954_1
A0A0J9XJ43_GEOCN55.014%3491.42e-135Similar to Saccharomyces cerevisiae YNL128W TEP1 Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway OS=Geotrichum candidum GN=BN980_GECA20s00604g PE=4 SV=1
UniRef50_A0A0J9XJ4355.014%3492.91e-132Similar to Saccharomyces cerevisiae YNL128W TEP1 Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJ43_GEOCN
A0A1E3PHH5_9ASCO36.752%3514.28e-75Phosphatases II OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52721 PE=4 SV=1
A0A060TAK7_BLAAD41.429%3501.11e-73ARAD1D24728p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D24728g PE=4 SV=1
Q59LZ6_CANAL36.104%3859.09e-53Putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEP1 PE=4 SV=1
A0A167DW17_9ASCO34.218%3399.95e-49Tep1p OS=Sugiyamaella lignohabitans GN=TEP1 PE=4 SV=1
Q6CCA7_YARLI36.975%2385.33e-45YALI0C11033p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C11033g PE=4 SV=1
TEP1_YEAST25.368%2724.59e-17Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEP1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7904

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 371

Detailed signature matches

  1. Domain IPR029021
    Protein-tyrosine phosphatase-like
    1. SSF52799 ((Phosphot...)
    2. G3DSA:3.90.19...
  2. Domain IPR029023
    Tensin-type phosphatase domain
    1. PS51181 (PPASE_TENSIN)
  3. Domain IPR000340
    Dual specificity phosphatase, catalytic domain
    1. PF00782 (DSPc)
  4. Domain IPR014020
    Tensin phosphatase, C2 domain
    1. PS51182 (C2_TENSIN)
  5. SITE IPR016130
    Protein-tyrosine phosphatase, active site
    1. PS00383 (TYR_PHOSPH...)

Protein sequence

>MIA_03131_1
MASVIRYAMASPKKQYFTGTCTLDLSYIMPNLIVCSMPTNNCIKGWYRMWLADLLVFLDQKHGCNWRLFNFQAEKSGYGD
QDVYGRVSHFPFPDHNPPPFELFPEAICAIKQYLACDTRNVAVLHCKAGKGRSGSMTCAFLMSAFRYSFEKATSLFTENR
MRTAFGDGISIASQRRYLRYVEDWVHVLDQQYYVPICIRIDSVRVWQPYYPEIDITVAHYTEGGAHINPVYTFTDADVAK
RMPEYIVLVPQCGIANDNGLGLVVPADVRFSFQHKFMIGGTLPVLHSSAYMWFNAFFETYGGADGFDFAQTTGCVSFLWN
DLDGFKGTSKRGSPLFERIDIFWSVVQGAPADEPIPGTCTTTTITTCTEEC

GO term prediction

Biological Process

GO:0016311 dephosphorylation

Molecular Function

GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity

Cellular Component

None predicted.