Protein

MCA_04954_1

Length
365 amino acids

Gene name: TEP1

Description: Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

Browser: contigC:4511025-4512123-

RNA-seq: read pairs 403, FPKM 13.6, percentile rank 31.8% (100% = highest expression)

Protein function

Annotation:TEP1Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
EGGNOG:0PJGDTEP1phosphatase
SGD closest match:S000005072TEP1Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
CGD closest match:CAL0000179965TEP1Putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Protein alignments

%idAln lengthE-value
MIA_03131_166.85%3622e-176MIA_03131_1
A0A0J9XJ43_GEOCN55.43%3594e-133Similar to Saccharomyces cerevisiae YNL128W TEP1 Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway OS=Geotrichum candidum GN=BN980_GECA20s00604g PE=4 SV=1
UniRef50_A0A0J9XJ4355.43%3597e-130Similar to Saccharomyces cerevisiae YNL128W TEP1 Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJ43_GEOCN
A0A1E3PHH5_9ASCO35.99%3643e-72Phosphatases II OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52721 PE=4 SV=1
A0A060TAK7_BLAAD39.56%3642e-67ARAD1D24728p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D24728g PE=4 SV=1
Q59LZ6_CANAL36.22%3922e-52Putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEP1 PE=4 SV=1
A0A167DW17_9ASCO34.84%3537e-48Tep1p OS=Sugiyamaella lignohabitans GN=TEP1 PE=4 SV=1
Q6CCA7_YARLI34.52%2522e-43YALI0C11033p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C11033g PE=4 SV=1
TEP1_YEAST33.65%2081e-20Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEP1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6118

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 365

Detailed signature matches

  1. Domain IPR029021
    Protein-tyrosine phosphatase-like
    1. SSF52799 ((Phosphot...)
    2. G3DSA:3.90.19...
  2. Domain IPR029023
    Tensin-type phosphatase domain
    1. PS51181 (PPASE_TENSIN)
  3. Domain IPR000340
    Dual specificity phosphatase, catalytic domain
    1. PF00782 (DSPc)
  4. SITE IPR016130
    Protein-tyrosine phosphatase, active site
    1. PS00383 (TYR_PHOSPH...)

Protein sequence

>MCA_04954_1
MASILRYAVASPKKQYFTGTCTLDLAYITPNLIVCSMPTSSCIKGWYRMWLDDLTNFLTEKHGDHWRFFNFQAERSGYGD
EEVYGKVSHFPFPDHNPPPFEMIPHFLLELKKFLCQNSLNVAVFHCKAGKGRSGTMACAYLMSNFKYSFDKATNIFTECR
MRAAFGEGISISSQRRYLRYVEDWVHVLKQQYYHPIKVKIKSIRIWNPYYPEIDISINTYSEGGKHIKQIYTFTEHDTTK
RLPEYVVLTPNIDSCLQEESFDSKIITDKNFDNNLLIVPADIQLVFQHKYMVGGTFPVLHSTAYTWFNAFFETYGNSEGF
DFSRKDGSISLLWADLDGFKGTKKRGSPLFERVDIFWKVFEDICL

GO term prediction

Biological Process

GO:0016311 dephosphorylation

Molecular Function

GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity

Cellular Component

None predicted.