MIA_03109_1

Protein

Length

497 amino acids

Protein function

EGGNOG:	0PH7W	FG03936.1	succinate-semialdehyde dehydrogenase
SGD closest match:	S000000210	UGA2	Succinate-semialdehyde dehydrogenase [NADP(+)]
CGD closest match:	CAL0000192412	UGA2	Uga2p

Protein alignments

	%id	Aln length	E-value
MCA_03087_1	70.955%	513	0.0	MCA_03087_1
A0A0J9XGX0_GEOCN	69.124%	502	0.0	Similar to Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source OS=Geotrichum candidum GN=BN980_GECA15s02936g PE=4 SV=1
A0A167CGH0_9ASCO	63.843%	484	0.0	Succinate-semialdehyde dehydrogenase (NAD(P)(+)) OS=Sugiyamaella lignohabitans GN=UGA2 PE=4 SV=1
UniRef50_A0A167CGH0	63.843%	484	0.0	Succinate-semialdehyde dehydrogenase (NAD(P)(+)) n=2 Tax=saccharomyceta TaxID=716545 RepID=A0A167CGH0_9ASCO
A0A1E4THN4_9ASCO	60.408%	490	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_122059 PE=4 SV=1
A0A060T3V5_BLAAD	46.473%	482	6.86e-137	ARAD1A12386p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12386g PE=3 SV=1
UGA2_YEAST	44.033%	486	8.77e-135	Succinate-semialdehyde dehydrogenase [NADP(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UGA2 PE=1 SV=2
Q59T88_CANAL	42.623%	488	1.27e-132	Uga2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UGA2 PE=3 SV=1
Q6C0B4_YARLI	43.089%	492	1.76e-129	YALI0F26191p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26191g PE=3 SV=1
A0A1E3PG13_9ASCO	42.029%	483	4.37e-124	Succinic semialdehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47537 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2056

Protein family membership

None predicted.

Domains and repeats

Domain
2 - 280
Aldehyde dehydrogenase N-terminal domain (IPR016162)
Domain
8 - 492
Aldehyde/histidinol dehydrogenase (IPR016161)
Aldehyde dehydrogenase domain (IPR015590)

1 50 100 150 200 250 300 350 400 450 497

Detailed signature matches

IPR016162

Aldehyde dehydrogenase N-terminal domain
1. G3DSA:3.40.60...
  
  2 - 280
  
  GENE3D
  G3DSA:3.40.605.10 (G3DSA:3.40.605.10)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  8 - 492
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR015590

Aldehyde dehydrogenase domain
1. PF00171 (Aldedh)
  
  25 - 488
  
  Pfam
  PF00171 (Aldedh)

no IPR

Unintegrated signatures

G3DSA:3.40.30...

281 - 474

GENE3D
G3DSA:3.40.309.10 (G3DSA:3.40.309.10)
cd07103 (ALDH_F5_SS...)

33 - 491

CDD
cd07103 (ALDH_F5_SSADH_GabD)

Residue annotation

tetramerization in...

71S

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

80L

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

121W

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

124G

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

125E

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

127E

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

128R

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

129Q

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

130H

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

131G

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

132S

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

133V

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

134A

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

139P

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

145N

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

146R

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

147M

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

152Q

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

237A

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

249K

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

253A

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

256A

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

313D

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

317N

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

364S

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

431Q

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

433A

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

434D

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

438R

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

440F

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

443I

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

445T

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

446G

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

447N

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

448V

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

449G

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

450L

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

451N

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

457S

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

460A

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

461P

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

467D

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

472K

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

485K

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

486V

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

487K

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

488T

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

489A

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

490T

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

491W

tetramerization interface
71S, 80L, 121W, 124G, 125E, 127E, 128R, 129Q, 130H, 131G, 132S, 133V, 134A, 139P, 145N, 146R, 147M, 152Q, 237A, 249K, 253A, 256A, 313D, 317N, 364S, 431Q, 433A, 434D, 438R, 440F, 443I, 445T, 446G, 447N, 448V, 449G, 450L, 451N, 457S, 460A, 461P, 467D, 472K, 485K, 486V, 487K, 488T, 489A, 490T, 491W
CDD
cd07103 (ALDH_F5_SSADH_GabD)
NAD(P) binding sit...

160L

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

161T

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

162P

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

163W

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

164N

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

172R

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

187K

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

189S

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

190P

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

241F

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

242T

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

243G

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

244S

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

247V

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

250L

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

251L

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

265E

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

266L

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

267G

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

299C

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

396E

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

398F

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

424L

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

462F

NAD(P) binding site
160L, 161T, 162P, 163W, 164N, 172R, 187K, 189S, 190P, 241F, 242T, 243G, 244S, 247V, 250L, 251L, 265E, 266L, 267G, 299C, 396E, 398F, 424L, 462F
CDD
cd07103 (ALDH_F5_SSADH_GabD)
catalytic residues...

164N

catalytic residues
164N, 265E, 296G, 299C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

265E

catalytic residues
164N, 265E, 296G, 299C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

296G

catalytic residues
164N, 265E, 296G, 299C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

299C

catalytic residues
164N, 265E, 296G, 299C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

Protein sequence

>MIA_03109_1
MSQSIKSVDPTLIQTGTFINNEFITPKGPTFDVIDPATGKPWIALTSATVADVSTAVDAAAAAFPSYSHLSARERAKLLL
EWDALIRSNKESLAHILVFETGKPYSEALGEIDYALTFSWWMAGEAERQHGSVANGNGPGPTADNRMVVIKQPVGVVACL
TPWNFPIALFVRKVATALAAGCTVVAKPSPETPISSLALAHLARQAGLPKGVLNVLPCDAANTPSIGKALCEHQAVAKIS
FTGSTAVGKLLAAQCAPHLKKLTLELGGNGPFIIFEDADLEKAVSNLMACKFRHAGQTCVCAQRVFVQASIYDRVLNMLK
LRMQEQLVPGHGLDNKSTLGPLTTPRSVKKAQSHVEDAVQRGASNVLSIEIPSSGYFFSPTLLADVTDEMLVAKEESFAP
ILSLFSFDSETEVLRRANATSMGLTSYVFSQDADRLWRMFEGIETGNVGLNVGMTTSAEAPFGGWHDSGYGKEAGLGYGI
GEYLKVKTATWRVNFSG

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component