MCA_03087_1

Protein

Length

523 amino acids

RNA-seq: read pairs 358, FPKM 8.4, percentile rank 23.2% (100% = highest expression)

Protein function

EGGNOG:	0PH7W	FG03936.1	succinate-semialdehyde dehydrogenase
SGD closest match:	S000000210	UGA2	Succinate-semialdehyde dehydrogenase [NADP(+)]
CGD closest match:	CAL0000192412	UGA2	Uga2p

Protein alignments

	%id	Aln length	E-value
MIA_03109_1	70.96%	513	0.0	MIA_03109_1
A0A0J9XGX0_GEOCN	65.13%	519	0.0	Similar to Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source OS=Geotrichum candidum GN=BN980_GECA15s02936g PE=4 SV=1
A0A167CGH0_9ASCO	58.70%	506	0.0	Succinate-semialdehyde dehydrogenase (NAD(P)(+)) OS=Sugiyamaella lignohabitans GN=UGA2 PE=4 SV=1
UniRef50_A0A167CGH0	58.70%	506	0.0	Succinate-semialdehyde dehydrogenase (NAD(P)(+)) n=2 Tax=saccharomyceta TaxID=716545 RepID=A0A167CGH0_9ASCO
A0A1E4THN4_9ASCO	57.65%	510	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_122059 PE=4 SV=1
A0A060T3V5_BLAAD	44.60%	509	3e-143	ARAD1A12386p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12386g PE=3 SV=1
A0A1E3PG13_9ASCO	44.27%	515	8e-140	Succinic semialdehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47537 PE=3 SV=1
Q6C0B4_YARLI	43.80%	516	7e-137	YALI0F26191p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26191g PE=3 SV=1
Q59T88_CANAL	41.55%	515	7e-137	Uga2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=UGA2 PE=3 SV=1
UGA2_YEAST	41.18%	510	2e-130	Succinate-semialdehyde dehydrogenase [NADP(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UGA2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1268

Protein family membership

None predicted.

Domains and repeats

Domain
7 - 282
Aldehyde dehydrogenase N-terminal domain (IPR016162)
Domain
10 - 519
Aldehyde/histidinol dehydrogenase (IPR016161)
Aldehyde dehydrogenase domain (IPR015590)

1 50 100 150 200 250 300 350 400 450 523

Detailed signature matches

IPR016162

Aldehyde dehydrogenase N-terminal domain
1. G3DSA:3.40.60...
  
  7 - 282
  
  GENE3D
  G3DSA:3.40.605.10 (G3DSA:3.40.605.10)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  10 - 374
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
  
  401 - 519
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR015590

Aldehyde dehydrogenase domain
1. PF00171 (Aldedh)
  
  29 - 516
  
  Pfam
  PF00171 (Aldedh)

no IPR

Unintegrated signatures

G3DSA:3.40.30...

283 - 502

GENE3D
G3DSA:3.40.309.10 (G3DSA:3.40.309.10)
cd07103 (ALDH_F5_SS...)

35 - 519

CDD
cd07103 (ALDH_F5_SSADH_GabD)

Residue annotation

tetramerization in...

73S

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

82L

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

123W

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

126G

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

127E

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

129E

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

130R

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

131Q

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

132Y

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

133G

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

134S

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

135V

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

136A

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

141P

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

147N

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

148R

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

149Y

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

154Q

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

239A

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

251K

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

255E

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

258A

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

315E

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

319Q

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

366K

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

459S

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

461A

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

462D

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

466R

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

468F

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

471I

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

473T

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

474G

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

475N

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

476V

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

477G

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

478I

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

479N

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

485S

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

488A

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

489P

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

495E

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

500K

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

513K

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

514V

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

515K

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

516S

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

517A

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

518T

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)

519W

tetramerization interface
73S, 82L, 123W, 126G, 127E, 129E, 130R, 131Q, 132Y, 133G, 134S, 135V, 136A, 141P, 147N, 148R, 149Y, 154Q, 239A, 251K, 255E, 258A, 315E, 319Q, 366K, 459S, 461A, 462D, 466R, 468F, 471I, 473T, 474G, 475N, 476V, 477G, 478I, 479N, 485S, 488A, 489P, 495E, 500K, 513K, 514V, 515K, 516S, 517A, 518T, 519W
CDD
cd07103 (ALDH_F5_SSADH_GabD)
NAD(P) binding sit...

162L

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

163T

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

164P

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

165W

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

166N

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

174R

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

189K

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

191S

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

192P

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

243F

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

244T

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

245G

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

246S

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

249I

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

252L

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

253L

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

267E

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

268L

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

269G

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

301C

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

424E

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

426F

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

452L

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)

490F

NAD(P) binding site
162L, 163T, 164P, 165W, 166N, 174R, 189K, 191S, 192P, 243F, 244T, 245G, 246S, 249I, 252L, 253L, 267E, 268L, 269G, 301C, 424E, 426F, 452L, 490F
CDD
cd07103 (ALDH_F5_SSADH_GabD)
catalytic residues...

166N

catalytic residues
166N, 267E, 298G, 301C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

267E

catalytic residues
166N, 267E, 298G, 301C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

298G

catalytic residues
166N, 267E, 298G, 301C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

301C

catalytic residues
166N, 267E, 298G, 301C
CDD
cd07103 (ALDH_F5_SSADH_GabD)

Protein sequence

>MCA_03087_1
MPSSFPVDLSDNTLLQTGAFVNNEFYTPKGASFEVIDPATGNAWIALHSCTAADVEPAVKAAESAFKDYKKLSARERAKL
ILKWDELIRENKEDLAQLLVFETGKPYAEALGEVEYALTFSWWMAGEAERQYGSVANGNGPGPTTNNRYVIIKQPIGVVA
TLTPWNFPIALFVRKVATALAAGCTVVNKPSPETPITCLALGLLAKRAGFAPGVINILPCDLGNTPSIGLALCQHPTVAK
ISFTGSTRIGKLLAEQCAPYLKKLTLELGGNGPFIIFEDADLDKAIDNLMACKFRHAGQTCVCAQRVFVQESILEKVEQM
LAKRIKSDLKMGHGLEKGTTLGPLTTPRSIGKAKSHVDDAVEQGAKLITGYSPKLSAPGSASSNISSSSTLNTVDNEAAP
QEGYFFPPTLISNVTDKMLVTQEESFAPVLSLLPFSTEEEVIERANNTSMGLTSYVFSSNADRLWRCFENIETGNVGINV
GMTTSAEAPFGGWKESGYGKEAGLGYGIEEYLKVKSATWRIDF

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component