Protein

MIA_03055_1

Length
576 amino acids

Browser: contig04:116617-118399+

Protein function

EGGNOG:0PIHZPGUG_04662tyrosyl-DNA phosphodiesterase
SGD closest match:S000000427TDP1Tyrosyl-DNA phosphodiesterase 1

Protein alignments

%idAln lengthE-value
MCA_01121_127.536%6902.23e-78MCA_01121_1
A0A060T8I0_BLAAD29.775%5342.24e-63ARAD1D11528p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D11528g PE=4 SV=1
UniRef50_A0A060T8I029.775%5345.53e-60ARAD1D11528p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T8I0_BLAAD
A0A167CK96_9ASCO30.912%5372.36e-60Tyrosyl-DNA phosphodiesterase 1 OS=Sugiyamaella lignohabitans GN=TDP1 PE=4 SV=1
A0A0J9X7L7_GEOCN28.421%5703.62e-55Similar to Saccharomyces cerevisiae YBR223C TDP1 Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions OS=Geotrichum candidum GN=BN980_GECA03s07853g PE=4 SV=1
A0A1E3PN91_9ASCO28.654%5201.55e-53Phospholipase D/nuclease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82232 PE=4 SV=1
Q6C9X4_YARLI32.847%4112.92e-50YALI0D07590p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D07590g PE=4 SV=1
TYDP1_YEAST19.672%4883.63e-10Tyrosyl-DNA phosphodiesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TDP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0128

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 576

Detailed signature matches

  1. Family IPR010347
    Tyrosyl-DNA phosphodiesterase I
    1. PF06087 (Tyr-DNA_ph...)
  2. Domain IPR027415
    Tyrosyl-DNA phosphodiesterase C-terminal domain
    1. G3DSA:3.30.87...
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.87...
  2. SSF56024 (Phospholi...)
  3. mobidb-lite (disord...)

Protein sequence

>MIA_03055_1
MANDRPDPPEEPRETDRPDDESDTSSVEIVDTYEIPVEALTSDDDDDEIVVTAQKPVERLTGAKRPYEDNGKEEDLLHTQ
KKLRTEFTDPNVIPSELRLSRIDDLGSEVNSDTVSLEYILNQAGLKYMWQFNFSVDIEFVMNSIEPWTRKNMWSWFIVSG
KPQDIIYYNSVVQSLPDQHRVAPVLGAPLHPSKNWSIHHAKLMVLGFTDDPEEDTKDLGTVTRFQIIISTSNLTPLDWHK
LTQGVWMSPHLRRGETTKRTDFRADFLGYLGLYKLPALQDLIEELGEFSFDEVTVDLVMSAPGNFNVGKEPPQMGVDGLG
SKMAQMATEKEEDTDKFTIEVSSLGSFGKDQKYFKEMFLKALNGDKDAPDLMKRTQLLWPSVESVRTSIAGYASGVALHE
NSRGGVDSLRKAGQLYEWKSLKAGRQFAMPHIKTYTRTNADKTQIRWIVLTSANLSQAAWGVIRGAARKSPKGMGPRVDG
SSWELGVVISPRWHESASGGGVSVVMVPVYGRDRLTDSEAGKTRELLGVSHECKLLCVRMAYDLNAMEPYKQGSQPWDGK
TGHSHRDWLGRQWPLE

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0008081 phosphoric diester hydrolase activity

Cellular Component

GO:0005634 nucleus