Protein
MCA_01121_1
Length
689 amino acids
Gene name: TDP1
Description: Tyrosyl-DNA phosphodiesterase 1
Browser: contigA:3567162-3569292+
RNA-seq: read pairs 608, FPKM 10.9, percentile rank 27.4% (100% = highest expression)
Protein function
| Annotation: | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | |
|---|---|---|---|
| KEGG: | K10862 | TDP1 | tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] |
| EGGNOG: | 0PIHZ | PGUG_04662 | tyrosyl-DNA phosphodiesterase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03055_1 | 30.08% | 605 | 9e-76 | MIA_03055_1 |
| A0A167CK96_9ASCO | 29.93% | 598 | 5e-67 | Tyrosyl-DNA phosphodiesterase 1 OS=Sugiyamaella lignohabitans GN=TDP1 PE=4 SV=1 |
| UniRef50_A0A167CK96 | 29.93% | 598 | 1e-63 | Tyrosyl-DNA phosphodiesterase 1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167CK96_9ASCO |
| A0A0J9X7L7_GEOCN | 29.73% | 676 | 6e-62 | Similar to Saccharomyces cerevisiae YBR223C TDP1 Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions OS=Geotrichum candidum GN=BN980_GECA03s07853g PE=4 SV=1 |
| A0A060T8I0_BLAAD | 28.14% | 590 | 4e-59 | ARAD1D11528p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D11528g PE=4 SV=1 |
| A0A1E3PN91_9ASCO | 29.05% | 599 | 7e-57 | Phospholipase D/nuclease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82232 PE=4 SV=1 |
| Q6C9X4_YARLI | 28.57% | 469 | 3e-49 | YALI0D07590p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D07590g PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0269
Protein family membership
- Tyrosyl-DNA phosphodiesterase I (IPR010347)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
689
Detailed signature matches
-
-
PF06087 (Tyr-DNA_ph...)
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no IPR
Unintegrated signatures
-
-
SSF56024 (Phospholi...)
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cd09123 (PLDc_Tdp1_2)
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mobidb-lite (disord...)
Residue annotation
-
domain interface c...
-
catalytic site cd0...
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putative active si...
Protein sequence
>MCA_01121_1 MADLVSDSDDEIEITDEKPSVKELSTTDEIEEVSVSCRKRPIESVDANDEKVANNSISNSHKRTKIELTPEEQKVQDQWR RFGRYATMVPEPDMVREPDDPNVISSPIRLLNIPEMPDSENIDTVSLGGILNKNGDLRYMWQINFSIELTYIMACIDVGI RKRLQSYFITGKSTRSDVGSNYNYCVSQLSEIPDGPQVQVCGVDMYNPFGSHHTKMMILGFSDNPSICKSHDEIKEIQVV IHTANLTPFDWTQMTQGAWISPRLKRTNLPRKKMGIFGNQLLQYLGYYKIEVTRNLCNLLNSFDFSGIPARIISSSPIYR YIPLDKKSEDATRDHFLTTDNRVGLNALRKEVCKIPKDEEKDWDKDEIIMQMSSIGQLGNTPTFLHDMVFRALYGKDFVS LSKTATTSGQSKLNFGSKNNKSNQCEPKSKSLTKSDLDRIKLIWPTISNVKDSVTGYMAGIALHMKLEGKQNMHQLDHLK PHLRVWRSLDAGRERVMPHVKTYLRINDRHDDIRWLLLTSANLSKSAWGLLSADSGKNAKSTKPTNANTLKIKMENWEAG VLIHPLLYLKPREITGIEFPLDSEEDIISDEKFLDNKLSNMGDEELKALYKANKRKVAMIPVFKRDFLTKKEADEYRKKH GLDPDAKLVCIRMFYDVPTQAYNWKGDIPWSSGCNPPEKDWMGQKWPMS
GO term prediction
Biological Process
GO:0006281 DNA repair
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Cellular Component
GO:0005634 nucleus