Protein

MIA_03042_1

Length
493 amino acids

Browser: contig04:91833-93315-

Protein function

EGGNOG:0PGIASLX1Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity)
SGD closest match:S000000432SLX1Structure-specific endonuclease subunit SLX1
CGD closest match:CAL0000188512SLX1Structure-specific endonuclease subunit SLX1

Protein alignments

%idAln lengthE-value
MCA_05074_147.635%2962.73e-80MCA_05074_1
A0A0J9X481_GEOCN51.613%1558.97e-48Structure-specific endonuclease subunit SLX1 OS=Geotrichum candidum GN=SLX1 PE=3 SV=1
UniRef50_A0A0J9X48151.613%1551.83e-44Structure-specific endonuclease subunit SLX1 n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X481_GEOCN
A0A167FIK7_9ASCO45.763%1777.26e-41Structure-specific endonuclease subunit SLX1 OS=Sugiyamaella lignohabitans GN=SLX1 PE=3 SV=1
A0A1E4THK1_9ASCO48.366%1537.14e-39Structure-specific endonuclease subunit SLX1 OS=Tortispora caseinolytica NRRL Y-17796 GN=SLX1 PE=3 SV=1
SLX1_YARLI45.806%1551.76e-37Structure-specific endonuclease subunit SLX1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SLX1 PE=3 SV=1
SLX1_YEAST44.667%1501.51e-36Structure-specific endonuclease subunit SLX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLX1 PE=1 SV=1
Q5A4X4_CANAL55.140%1071.41e-30Structure-specific endonuclease subunit SLX1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SLX1 PE=3 SV=1
A0A1E3PUI2_9ASCO42.282%1499.32e-30Structure-specific endonuclease subunit SLX1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=SLX1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0574
Predicted cleavage: 14

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 493

Detailed signature matches

  1. Family IPR027520
    Structure-specific endonuclease subunit Slx1
    1. MF_03100 (Endonuc_s...)
  2. Domain IPR000305
    GIY-YIG nuclease superfamily
    1. PS50164 (GIY_YIG)
    2. SSF82771 (GIY-YIG e...)
    3. PF01541 (GIY-YIG)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd10455 (GIY-YIG_SLX1)
  2. mobidb-lite (disord...)

Residue annotation

  1. GIY-YIG motif/moti...
  2. putative active si...
  3. putative metal bin...

Protein sequence

>MIA_03042_1
MSNLITFNPANRPKSLSAPASSDNGTTDNFNNDTLSNNPLRSSSKDRPTTVPSQWPIFYSCYLLQSSKSPRSFYIGSTPD
PIRRLRQHNGVLKSGGAYRTRSDKKRVWRAVAIVCGFQSKVAALQFEHAWQHPHITRHINSNTNLSTDQPQVPEDAQKKK
PVKPRTLVGHLTVMRSLMQAPLFSHMPLDLYILEKSSFEAWRKLTNDIKKHKNYQETDDRFNVILDYDEFKPITDYATCD
PTHFDDMRPTRVKKPTSKNQPRPESTSSEHNPIIIDEDELGDESGSEIDENALTEPRQIPILGGPRRCLLKRLRSEHTRE
FQLVQDILRKLNLEKKSQLEQDLELEISMKKHSAFDDMDHDDENDNSFGYGLYGSQDYIVGAPNYQITKIRNDNHSTRLC
RLSLKPIHLCQDLMAVCMVCGSTLHLTELAKYALKAGPYANGKQKETGIIPVLPTKFNCPFCSDEMYWRDVSRLAYLLQK
HFLSDSEYYGEKI

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0017108 5'-flap endonuclease activity

Cellular Component

GO:0033557 Slx1-Slx4 complex