Protein
MCA_05074_1
Length
411 amino acids
Gene name: SLX1
Description: Structure-specific endonuclease subunit SLX1
Browser: contigD:304189-305425+
RNA-seq: read pairs 119, FPKM 3.6, percentile rank 14.9% (100% = highest expression)
Protein function
| Annotation: | SLX1 | Structure-specific endonuclease subunit SLX1 | |
|---|---|---|---|
| KEGG: | K15078 | SLX1 | structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] |
| EGGNOG: | 0PGIA | SLX1 | Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity) |
| SGD closest match: | S000000432 | SLX1 | Structure-specific endonuclease subunit SLX1 |
| CGD closest match: | CAL0000188512 | SLX1 | Structure-specific endonuclease subunit SLX1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03042_1 | 47.65% | 298 | 4e-79 | MIA_03042_1 |
| A0A0J9X481_GEOCN | 32.02% | 381 | 8e-54 | Structure-specific endonuclease subunit SLX1 OS=Geotrichum candidum GN=SLX1 PE=3 SV=1 |
| UniRef50_A0A0J9X481 | 32.02% | 381 | 2e-50 | Structure-specific endonuclease subunit SLX1 n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X481_GEOCN |
| A0A167FIK7_9ASCO | 30.77% | 364 | 6e-42 | Structure-specific endonuclease subunit SLX1 OS=Sugiyamaella lignohabitans GN=SLX1 PE=3 SV=1 |
| SLX1_YEAST | 41.62% | 173 | 9e-40 | Structure-specific endonuclease subunit SLX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLX1 PE=1 SV=1 |
| SLX1_YARLI | 36.59% | 205 | 1e-39 | Structure-specific endonuclease subunit SLX1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SLX1 PE=3 SV=1 |
| A0A1E4THK1_9ASCO | 38.79% | 214 | 4e-39 | Structure-specific endonuclease subunit SLX1 OS=Tortispora caseinolytica NRRL Y-17796 GN=SLX1 PE=3 SV=1 |
| Q5A4X4_CANAL | 66.28% | 86 | 1e-32 | Structure-specific endonuclease subunit SLX1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SLX1 PE=3 SV=1 |
| A0A1E3PUI2_9ASCO | 36.36% | 187 | 4e-30 | Structure-specific endonuclease subunit SLX1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=SLX1 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0632
Protein family membership
- Structure-specific endonuclease subunit Slx1 (IPR027520)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
411
Detailed signature matches
-
-
MF_03100 (Endonuc_s...)
-
no IPR
Unintegrated signatures
-
cd10455 (GIY-YIG_SLX1)
-
mobidb-lite (disord...)
Residue annotation
-
GIY-YIG motif/moti...
-
putative active si...
-
putative metal bin...
Protein sequence
>MCA_05074_1 MQEMNSYSSTSSNFDTTSVSTSTSASSSASKRYQWPSFYSCYLLQSSKSPRSFYIGSTPDPVRRLRQHNGVLACGGAYRT KSDKKRVWRAVVIVTGFQSKVAALQFEHAWQHPHTTRHIDSTDSVFPKRSSNKPSSSVGLPIVNKNSPKPKTKLQLNRTA RSMKSHLSVMKALLEAPLFTYMPLQVYFLEKESYESWVKNSFIASTAPIAPSFEVVPDFDNERKITDYSVMNASQFDDLR PPRSNRKDSGIVLKVGSVSDSEGEGEEEDEESQHTISKIPIFGGPQKLLLKRFRSAKLQECELVEHACTKLGILPPIDKD GNIVSPIIRTFMCNLTKASVTLGRDMLTICLKCGSRYLLTALAKYAMGASGASQDEVLPKGNFNCPSCYTEMTWSSVSKL AYLLRTEFAMT
GO term prediction
Biological Process
GO:0006281 DNA repair
Molecular Function
GO:0017108 5'-flap endonuclease activity
Cellular Component
GO:0033557 Slx1-Slx4 complex