Protein

MIA_03027_1

Length
365 amino acids

Browser: contig04:49855-50953-

Protein function

EGGNOG:0PG8GLYS1saccharopine dehydrogenase
SGD closest match:S000001473LYS1Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
CGD closest match:CAL0000179135LYS1Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

Protein alignments

%idAln lengthE-value
MCA_04945_185.870%3680.0MCA_04945_1
A0A0J9YHC2_GEOCN80.926%3670.0Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Geotrichum candidum GN=BN980_GECA01s02265g PE=3 SV=1
LYS1_YARLI78.474%3670.0Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LYS5 PE=3 SV=1
A0A167DTV6_9ASCO73.025%3675.71e-170Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Sugiyamaella lignohabitans GN=LYS1 PE=3 SV=1
A0A060T7A0_BLAAD74.238%3618.92e-168Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C19690g PE=3 SV=1
LYS1_YEAST70.492%3661.65e-162Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS1 PE=1 SV=3
UniRef50_P3899870.492%3663.95e-159Saccharopine dehydrogenase [NAD(+), L-lysine-forming] n=282 Tax=Eukaryota TaxID=2759 RepID=LYS1_YEAST
A0A1E3PMF1_9ASCO70.190%3697.51e-161Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82382 PE=3 SV=1
A0A1D8PMA1_CANAL67.374%3773.09e-152Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LYS1 PE=3 SV=1
A0A1E4TCN5_9ASCO69.505%3647.94e-152Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4130 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2241
Predicted cleavage: 12

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 365

Detailed signature matches

  1. Family IPR027281
    Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
    1. PIRSF018250 (Saccha...)
    2. cd12188 (SDH)
  2. Domain IPR007886
    Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
    1. SM01003 (AlaDh_PNT_N_2)
    2. PF05222 (AlaDh_PNT_N)
  3. Domain IPR007698
    Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
    1. SM01002 (AlaDh_PNT_C_2)
  4. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SSF52283 (Formate/g...)

Residue annotation

  1. ligand binding sit...
  2. active site cd12188
  3. homodimer interfac...
  4. NAD(P) binding sit...

Protein sequence

>MIA_03027_1
MSAPVTLHLRAETKPLEHRAALTPTTTKKLLDAGFNVIVEKSSQSTFDIKEYEAVGATIAEEGSWPQAPKDHIIIGLKEL
PEESFPLIHEHIQFAHCYKDQGGWKDVLKRFPEGKGTLYDLEFLEDDNGRRVAAFGFHAGFAGAAIGLKDWAFRQTHSDD
ESLAAIEPFPYEHLLVEDVKKDLASAGKALPKVLVIGALGRCGSGAVDLCRKAGIPEENIIKWDIAETSKGGPFQEIADA
DIFINCIYLSKPIPPFINFDLLNKESRKLQVIVDVSADTTNPHNPIPVYTVATVFNKPTVRVETTVGPRLDVVSIDHLPS
LLPREASEAYSEALLPSLLELPNRDTAPVWTRAKALFDHHVARLD

GO term prediction

Biological Process

GO:0009085 lysine biosynthetic process

Molecular Function

GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity

Cellular Component

None predicted.