Protein

MCA_04945_1

Length
370 amino acids

Gene name: LYS1

Description: Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

Browser: contigC:4489094-4490207+

RNA-seq: read pairs 8923, FPKM 297.2, percentile rank 91.8% (100% = highest expression)

Protein function

Annotation:LYS1Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
KEGG:K00290LYS1 saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]
EGGNOG:0PG8GLYS1saccharopine dehydrogenase
SGD closest match:S000001473LYS1Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
CGD closest match:CAL0000179135LYS1Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

Protein alignments

%idAln lengthE-value
MIA_03027_184.78%3680.0MIA_03027_1
A0A0J9YHC2_GEOCN73.98%3694e-168Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Geotrichum candidum GN=BN980_GECA01s02265g PE=3 SV=1
LYS1_YARLI74.25%3691e-163Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LYS5 PE=3 SV=1
A0A1E3PMF1_9ASCO71.27%3691e-158Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82382 PE=3 SV=1
A0A060T7A0_BLAAD71.51%3651e-157Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C19690g PE=3 SV=1
A0A167DTV6_9ASCO70.00%3703e-157Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Sugiyamaella lignohabitans GN=LYS1 PE=3 SV=1
LYS1_YEAST68.22%3651e-147Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS1 PE=1 SV=3
UniRef50_P3899868.22%3653e-144Saccharopine dehydrogenase [NAD(+), L-lysine-forming] n=282 Tax=Eukaryota TaxID=2759 RepID=LYS1_YEAST
A0A1E4TCN5_9ASCO69.23%3643e-145Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4130 PE=3 SV=1
A0A1D8PMA1_CANAL66.22%3767e-143Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LYS1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1737
Predicted cleavage: 12

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 370

Detailed signature matches

  1. Family IPR027281
    Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
    1. PIRSF018250 (Saccha...)
    2. cd12188 (SDH)
  2. Domain IPR007886
    Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
    1. SM01003 (AlaDh_PNT_N_2)
    2. PF05222 (AlaDh_PNT_N)
  3. Domain IPR007698
    Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
    1. SM01002 (AlaDh_PNT_C_2)
  4. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SSF52283 (Formate/g...)

Residue annotation

  1. ligand binding sit...
  2. active site cd12188
  3. homodimer interfac...
  4. NAD(P) binding sit...

Protein sequence

>MCA_04945_1
MPSPVTLHLRAETKPLEHRAALTPTTTKKLLDAGFNVIVEKSSQSTFDIKEYEAVGATIAEEGSWVNAPKDHIIIGLKEL
PEDTFPLTNEHIQFAHCYKDQAGWKDVLKRFPEGNGVLYDLEFLEDDNGRRVAAFGFHAGFAGAAIGLKDWAFRQTHSDS
ESLGSIDPFPYEHLLVEEVKKEVDEAVAKTNKNLPKVLVIGALGRSGRGAVDFCQKVGIPDQNIIKWDMEETSKGGPFQE
IIDADIFINCIYLSKPIPPFVTFETLNDEKRNLQVIVDVSADTTNPHNPIPVYTIATTFSEPTVKVETSKGPALDVVSID
HLPSLLPREASEAYSEALLPSLLELPTRDTAPVWTRAKALFDHHVARLSN

GO term prediction

Biological Process

GO:0009085 lysine biosynthetic process

Molecular Function

GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity

Cellular Component

None predicted.