Protein

MIA_03019_1

Length
624 amino acids

Browser: contig04:35086-36961+

Protein function

EGGNOG:0PG8CVPS27Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane
SGD closest match:S000005289VPS27Vacuolar protein sorting-associated protein 27
CGD closest match:CAL0000186855VPS27Vacuolar protein sorting-associated protein 27

Protein alignments

%idAln lengthE-value
MCA_05873_164.410%4580.0MCA_05873_1
A0A0J9XKT4_GEOCN60.841%4520.0Similar to Saccharomyces cerevisiae YNR006W VPS27 Endosomal protein that forms a complex with Hse1p OS=Geotrichum candidum GN=BN980_GECA25s00813g PE=4 SV=1
UniRef50_A0A0J9XKT460.841%4521.42e-179Similar to Saccharomyces cerevisiae YNR006W VPS27 Endosomal protein that forms a complex with Hse1p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XKT4_GEOCN
A0A1E3PK51_9ASCO52.165%4623.19e-155VHS-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_35468 PE=4 SV=1
A0A060TFB9_BLAAD52.421%4751.34e-152ARAD1D21912p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D21912g PE=4 SV=1
VPS27_YARLI53.571%4481.06e-147Vacuolar protein sorting-associated protein 27 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=VPS27 PE=3 SV=1
A0A167C393_9ASCO50.964%4676.04e-146ESCRT-0 subunit protein VPS27 OS=Sugiyamaella lignohabitans GN=VPS27 PE=4 SV=1
A0A1E4TAZ5_9ASCO44.749%4382.85e-124Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19913 PE=4 SV=1
VPS27_YEAST38.514%4449.04e-88Vacuolar protein sorting-associated protein 27 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS27 PE=1 SV=3
VPS27_CANAL37.337%3832.39e-62Vacuolar protein sorting-associated protein 27 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS27 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0824

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 624

Detailed signature matches

  1. Family IPR017073
    Ubiquitin binding protein, Hrs/VPS27
    1. PIRSF036956 (Hrs_Vps27)
  2. Domain IPR008942
    ENTH/VHS
    1. SSF48464 (ENTH/VHS ...)
    2. G3DSA:1.25.40.90
  3. Domain IPR002014
    VHS domain
    1. PS50179 (VHS)
    2. PF00790 (VHS)
    3. SM00288 (VHS_2)
  4. Domain IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  5. Domain IPR011011
    Zinc finger, FYVE/PHD-type
    1. SSF57903 (FYVE/PHD ...)
  6. Domain IPR000306
    FYVE zinc finger
    1. PF01363 (FYVE)
    2. SM00064 (fyve_4)
  7. Domain IPR017455
    Zinc finger, FYVE-related
    1. PS50178 (ZF_FYVE)
  8. SITE IPR003903
    Ubiquitin interacting motif
    1. SM00726 (uim)
    2. PF02809 (UIM)
    3. PS50330 (UIM)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd03569 (VHS_Hrs_Vp...)
  2. mobidb-lite (disord...)

Residue annotation

  1. membrane interface...
  2. FYVE interaction s...

Protein sequence

>MIA_03019_1
MASWFFSSSTPSIDEYVLKATAETLPTGEQDLALNLEICDLIRSKTVQPKDAMRALKRRLLHKNPNVQIATLHLTDVCIM
NGGMHFLVEIASREFMDTVVLVLKPLSGTPNPDVKALALECIQNWAKTFEGQLQLEYVGKVYRQLKDEGFTFPRAKTTLN
STFIDTAAPPEWVDSDTCMKSGTPFSFVNRKHHCRNCGGVFIQKYCNNYAPLPHFGINQPVRICDDCNEKLTKGHKDSKH
HQNKEPATASAAAATPYRQAPAIDEEEDADLKRALELSLKETQGSSAPVPNTQPNPTQASQNTTSTYDEEFDEDMKAAIA
ASLQEMKGTSPTANTATATAAPAPLTSSVTPSIQRPSWELTQLEADNINMYSTLVEKLQNAPPGAILREGKLQDLNESIG
ALRPKLARTLADAVTKYDRLVDMNSKLTTAMRYYDRLLEDRLSYAYGRYSLGAGLTQQQQPQQQQLTGYGQPYTQGYQGY
APQQQTPTGYAPSSYTPSAPAAGLASSYAPSAPSAPSAPSAPSAPSAPSAPSAPSAPSAPSAPSAPSAPSAPSAPSTFQP
SSPSNYQSQPVPSYSTYPGYSTQASAPPYGYTSPTQSTAPVPVAAPVVAAAPAPPKEEAPLIDL

GO term prediction

Biological Process

GO:0006886 intracellular protein transport

Molecular Function

GO:0046872 metal ion binding

Cellular Component

None predicted.