Protein
MCA_05873_1
Length
717 amino acids
Gene name: VPS27
Description: Vacuolar protein sorting-associated protein 27
Browser: contigD:2604589-2606743-
RNA-seq: read pairs 2733, FPKM 47.0, percentile rank 64.0% (100% = highest expression)
Protein function
| Annotation: | VPS27 | Vacuolar protein sorting-associated protein 27 | |
|---|---|---|---|
| KEGG: | K12182 | HGS | hepatocyte growth factor-regulated tyrosine kinase substrate |
| EGGNOG: | 0PG8C | VPS27 | Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane |
| SGD closest match: | S000005289 | VPS27 | Vacuolar protein sorting-associated protein 27 |
| CGD closest match: | CAL0000186855 | VPS27 | Vacuolar protein sorting-associated protein 27 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03019_1 | 62.75% | 459 | 0.0 | MIA_03019_1 |
| A0A0J9XKT4_GEOCN | 56.79% | 449 | 1e-164 | Similar to Saccharomyces cerevisiae YNR006W VPS27 Endosomal protein that forms a complex with Hse1p OS=Geotrichum candidum GN=BN980_GECA25s00813g PE=4 SV=1 |
| UniRef50_A0A0J9XKT4 | 56.79% | 449 | 2e-161 | Similar to Saccharomyces cerevisiae YNR006W VPS27 Endosomal protein that forms a complex with Hse1p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XKT4_GEOCN |
| A0A1E3PK51_9ASCO | 49.78% | 460 | 8e-136 | VHS-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_35468 PE=4 SV=1 |
| VPS27_YARLI | 48.12% | 451 | 1e-126 | Vacuolar protein sorting-associated protein 27 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=VPS27 PE=3 SV=1 |
| A0A167C393_9ASCO | 48.09% | 472 | 1e-124 | ESCRT-0 subunit protein VPS27 OS=Sugiyamaella lignohabitans GN=VPS27 PE=4 SV=1 |
| A0A060TFB9_BLAAD | 55.56% | 333 | 1e-112 | ARAD1D21912p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D21912g PE=4 SV=1 |
| A0A1E4TAZ5_9ASCO | 41.24% | 434 | 2e-105 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19913 PE=4 SV=1 |
| VPS27_YEAST | 37.59% | 439 | 5e-83 | Vacuolar protein sorting-associated protein 27 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS27 PE=1 SV=3 |
| VPS27_CANAL | 37.82% | 357 | 2e-51 | Vacuolar protein sorting-associated protein 27 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS27 PE=3 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1985
Protein family membership
- Ubiquitin binding protein, Hrs/VPS27 (IPR017073)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
717
Detailed signature matches
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PIRSF036956 (Hrs_Vps27)
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SSF48464 (ENTH/VHS ...)
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SSF57903 (FYVE/PHD ...)
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PS50178 (ZF_FYVE)
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no IPR
Unintegrated signatures
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cd03569 (VHS_Hrs_Vp...)
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mobidb-lite (disord...)
Residue annotation
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membrane interface...
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FYVE interaction s...
Protein sequence
>MCA_05873_1 MASWFFSGPRSNFEEVVQNATSESLPTGEQDLALNLAICDMIRSKTVAPKEAMRCLKHRLISSKNPNVQLATLNLINVCI LNGGTHFLIEIASREFMDTLVMLLKPDDGKKTNKDVVQLILASIQDWSKAFEGQLQLEYVSQVYKKLKDEGFEFPPPKNL NASYIDSSAPPEWADSDTCMKCGTLFSFVNRKHHCRNCGGVYDQKHCNNYLPIPKYGINVPVRVCDDCASKLKSKGGKDS KKIKSKTETSPSSSSNPPPPYLTEEEDEDLKRALELSLEESRKSNPYSSTAPAPSSTTTNTTAPAATSGGDDDFDEDMKA AIAASLRDMGMAAPDANAPSSNAQPNSSSNAPISIQRPSWELTQLETDNINMYSTLVEKMKKGPPGAILRESTLQDLNES IGALRPKLARTLADAVTKYDKLVDMNSKLTTAMRYYDKLLEDRLNYAYGRYSISSPAAMNAIPTGQQPQHQYNHHPPTYQ NPNYTGGSYQQPQYTGQQPPVAPQYSGQPHAPVQPQFSGQTPLSPNMTPSAPMYSHPYSQPYASNPSTVPVGAPSAPPSA PSAPSAPPAPVPSASSASTPSAPHPASSPVTNIADPSVPPVGSSPVVSRAVPQAPSVSSPLATQSQLANAPSAPGYPQVP YSAPSQPQPQVASPSPSSPNNTYNNPQAQAPSYTGLTVPSAPSVPPSYSYAAPPPQALPSQQQQPAPPKDEAPLIEL
GO term prediction
Biological Process
GO:0006886 intracellular protein transport
Molecular Function
GO:0046872 metal ion binding
Cellular Component
None predicted.