Protein

MIA_03014_1

Length
558 amino acids

Browser: contig04:25911-27588-

Protein function

EGGNOG:0PG19FG07283.1D-lactate dehydrogenase
SGD closest match:S000002337DLD2D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2
CGD closest match:CAL0000192859AIP2D-lactate dehydrogenase

Protein alignments

%idAln lengthE-value
MCA_05879_174.609%5120.0MCA_05879_1
A0A0J9X9C2_GEOCN72.366%5030.0Similar to Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase, located in the mitochondrial matrix OS=Geotrichum candidum GN=BN980_GECA06s00549g PE=4 SV=1
A0A167EQR2_9ASCO69.246%5040.0Dld2p OS=Sugiyamaella lignohabitans GN=DLD2 PE=4 SV=1
A0A1E3PHF7_9ASCO67.984%5060.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25106 PE=4 SV=1
A0A060T7G3_BLAAD65.600%5000.0ARAD1B23650p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B23650g PE=4 SV=1
A0A1D8PJK5_CANAL63.672%5120.0D-lactate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=AIP2 PE=4 SV=1
Q6CCU5_YARLI61.284%5140.0YALI0C06446p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C06446g PE=4 SV=1
UniRef50_Q5AUJ763.221%5030.0Uncharacterized protein n=3 Tax=Aspergillus TaxID=5052 RepID=Q5AUJ7_EMENI
DLD2_YEAST59.687%5110.0D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DLD2 PE=1 SV=1
A0A1E4TLA1_9ASCO28.200%4612.29e-48Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20771 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9998
Predicted cleavage: 53

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 558

Detailed signature matches

  1. Domain IPR016167
    FAD-binding, type 2, subdomain 1
    1. G3DSA:3.30.43.10
  2. Domain IPR016166
    FAD-binding, type 2
    1. PS51387 (FAD_PCMH)
    2. SSF56176 (FAD-bindi...)
  3. Domain IPR006094
    FAD linked oxidase, N-terminal
    1. PF01565 (FAD_binding_4)
  4. Domain IPR016169
    CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    1. G3DSA:3.30.46...
  5. Domain IPR016164
    FAD-linked oxidase-like, C-terminal
    1. SSF55103 (FAD-linke...)
  6. Domain IPR004113
    FAD-linked oxidase, C-terminal
    1. PF02913 (FAD-oxidase_C)
  7. Domain IPR016171
    Vanillyl-alcohol oxidase, C-terminal subdomain 2
    1. G3DSA:1.10.45.10
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)

Protein sequence

>MIA_03014_1
MIRSTRAFVSAAPRAAAKVAISRPAILRIAATSLASSASTTTRFFSATSCSRSIKTVKLTSETYPEIKRADFAQITPEDV
AFFKTVIPETAVLEATKDDLENYNQDWMRKYKGQTQIVLKPTSAEQISKILKHCNERRLAVVPQGGNTGLVGGSVPVFDE
IVISLTNMNKVRSFDSVTGILVADAGLILENADQYVAEHGFIFPLDLGAKGSCHIGGNVATNAGGLRLLRYGSLHGSVLG
IEAVLADGTIVHNLSKLRKDNTGYDLKQLFIGSEGTLGVITGISILCPPRPTAVNVAFLGLESFEKVQQTFVKAKRELSE
ILSAFECMDNTTQDLVEMHTDLVRPLSQKYPFYVLIETSGSSKEHDDEKLAAFLESAMSGENSDGSSSEPVILDGVLAQD
STDVSNLWQWRELIPEALSKNGGVYKYDVSIPLNRLYDLVIDVQKRLAEAGVVDGDAQNSSSEAPPVIAAAGYGHIGDGN
LHLNVSVRRYDKAVEKLLEPYVYEWIEKVQGSISAEHGLGLQKKNYIGYSKNEVMLSLMRRTKREYDPNGILNPYKYL

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.