Protein

MCA_05879_1

Length
565 amino acids

Gene name: DLD2

Description: D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase

Browser: contigD:2619654-2621352+

RNA-seq: read pairs 2200, FPKM 48.0, percentile rank 64.6% (100% = highest expression)

Protein function

Annotation:DLD2D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase
KEGG:K21618DLD3 (R)-2-hydroxyglutarate---pyruvate transhydrogenase [EC:1.1.99.40]
EGGNOG:0PG19FG07283.1D-lactate dehydrogenase
SGD closest match:S000002337DLD2D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2
CGD closest match:CAL0000192859AIP2D-lactate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_03014_174.61%5120.0MIA_03014_1
A0A0J9X9C2_GEOCN70.39%5100.0Similar to Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase, located in the mitochondrial matrix OS=Geotrichum candidum GN=BN980_GECA06s00549g PE=4 SV=1
A0A167EQR2_9ASCO64.78%5650.0Dld2p OS=Sugiyamaella lignohabitans GN=DLD2 PE=4 SV=1
A0A060T7G3_BLAAD65.53%5280.0ARAD1B23650p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B23650g PE=4 SV=1
A0A1E3PHF7_9ASCO67.72%5050.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25106 PE=4 SV=1
Q6CCU5_YARLI62.69%5360.0YALI0C06446p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C06446g PE=4 SV=1
A0A1D8PJK5_CANAL63.00%5270.0D-lactate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=AIP2 PE=4 SV=1
DLD2_YEAST57.50%5530.0D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DLD2 PE=1 SV=1
UniRef50_P4668157.50%5530.0D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 n=74 Tax=saccharomyceta TaxID=716545 RepID=DLD2_YEAST
A0A1E4TLA1_9ASCO31.60%4433e-51Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20771 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9972
Predicted cleavage: 62

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 565

Detailed signature matches

  1. Domain IPR016167
    FAD-binding, type 2, subdomain 1
    1. G3DSA:3.30.43.10
  2. Domain IPR016166
    FAD-binding, type 2
    1. PS51387 (FAD_PCMH)
    2. SSF56176 (FAD-bindi...)
  3. Domain IPR006094
    FAD linked oxidase, N-terminal
    1. PF01565 (FAD_binding_4)
  4. Domain IPR016169
    CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    1. G3DSA:3.30.46...
  5. Domain IPR016164
    FAD-linked oxidase-like, C-terminal
    1. SSF55103 (FAD-linke...)
  6. Domain IPR004113
    FAD-linked oxidase, C-terminal
    1. PF02913 (FAD-oxidase_C)
  7. Domain IPR016171
    Vanillyl-alcohol oxidase, C-terminal subdomain 2
    1. G3DSA:1.10.45.10

Protein sequence

>MCA_05879_1
MIKNSIAQSSKRALFRNLTTKSSQSSISLARGAYSSFSAAKSSNIASQLAAAKYPGLIRLYSSATKKEVKLTAETYPSLQ
RDSRYAKLTKEDVEHFKTIVPENAILWDQTNDVDDFEPFNQDWMRKYKGQTQLVLKPSTTEQVSAILKHCNARKLAVVPQ
GGNTGLVGGSVPVFDEIVISLANMNKIISFDDVSGILVAEAGVILETADTYARNKGFVFPLDLGAKGSCHIGGNVATNAG
GLRLLRYGSLHGTVLGLEAVLADGTVVNNLSKLRKDNTGYDLKQLFIGSEGTLGIVTKISILCPPKPTAVNVAFLGLESF
EQVQKTFVKAKKDLNEILSAFECMDNTTQDMVENHTDLTRPLSEKYPFYVLIETSGSDKQHDDEKLERFLESALGGEEGS
EPLILDGVVAQDNSEVANLWAWRELIPEALSKTGGVYKYDVSIPLPKLYDLVVDIQARLEEAGVVSLEDESKPAVTAAGY
GHIGDGNLHLNVAVRRYDKSVESVMEPFVYEWVQKVEGSISAEHGLGLQKKNYIQYSKDQGMIELMKRTKDQFDPNHILN
PYKYI

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding

Cellular Component

None predicted.