MIA_02990_1

Protein

Length

1,384 amino acids

Protein function

EGGNOG:	0PF9Z	SSK2	kinase kinase kinase
SGD closest match:	S000005314	SSK2	MAP kinase kinase kinase SSK2
CGD closest match:	CAL0000187689	SSK2	Mitogen-activated protein kinase kinase kinase

Protein alignments

	%id	Aln length	E-value
MCA_02630_1	61.26%	1208	0.0	MCA_02630_1
A0A0J9XE87_GEOCN	53.95%	1216	0.0	Similar to Saccharomyces cerevisiae YNR031C SSK2 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway OS=Geotrichum candidum GN=BN980_GECA12s01011g PE=4 SV=1
UniRef50_A0A0J9XE87	53.95%	1216	0.0	Similar to Saccharomyces cerevisiae YNR031C SSK2 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XE87_GEOCN
A0A060T7T8_BLAAD	47.91%	1223	0.0	ARAD1C30382p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C30382g PE=4 SV=1
Q6CHT2_YARLI	41.67%	1212	0.0	YALI0A05247p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A05247g PE=4 SV=1
A0A1E3PQ57_9ASCO	48.52%	880	0.0	Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81915 PE=4 SV=1
A0A1D8PM87_CANAL	39.61%	1194	0.0	Mitogen-activated protein kinase kinase kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SSK2 PE=4 SV=1
A0A167BWT7_9ASCO	55.00%	680	0.0	Mitogen-activated protein kinase kinase kinase SSK2 OS=Sugiyamaella lignohabitans GN=SSK2 PE=4 SV=1
SSK2_YEAST	44.61%	621	1e-157	MAP kinase kinase kinase SSK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SSK2 PE=1 SV=1
A0A1E4TKK1_9ASCO	48.64%	442	1e-135	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55972 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0279

Protein family membership

None predicted.

Domains and repeats

Domain
1,059 - 1,374
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 200 400 600 800 1000 1200 1384

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,269 - 1,374
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  1,059 - 1,220
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  1,060 - 1,370
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. PF00069 (Pkinase)
  
  1,061 - 1,370
  
  Pfam
  PF00069 (Pkinase)
3. SM00220 (serkin_6)
  
  1,060 - 1,370
  
  SMART
  SM00220 (serkin_6)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  1,066 - 1,089
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  1,180 - 1,192
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

G3DSA:1.10.51...

1,337 - 1,372

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)

1,130 - 1,336

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

1,048 - 1,129

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd06626 (STKc_MEKK4)

1,059 - 1,370

CDD
cd06626 (STKc_MEKK4)
mobidb-lite (disord...)

1,242 - 1,265

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 186

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,066I

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,067G

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,068A

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,069G

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,070S

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,074V

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,087A

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,089K

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,122V

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,138M

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,139E

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,140Y

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,141C

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,143G

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,144G

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,145S

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,148R

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,188E

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,189N

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,191L

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,201V

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,202D

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)

1,203F

ATP binding site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,143G, 1,144G, 1,145S, 1,148R, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,203F
CDD
cd06626 (STKc_MEKK4)
active site cd06626

1,066I

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,067G

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,068A

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,069G

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,070S

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,074V

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,087A

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,089K

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,122V

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,138M

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,139E

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,140Y

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,141C

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,144G

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,145S

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,148R

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,184D

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,186K

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,187P

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,188E

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,189N

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,191L

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,201V

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,202D

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,205A

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,269M

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,270I

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,271G

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,272T

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,274M

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,304E

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,313A

active site
1,066I, 1,067G, 1,068A, 1,069G, 1,070S, 1,074V, 1,087A, 1,089K, 1,122V, 1,138M, 1,139E, 1,140Y, 1,141C, 1,144G, 1,145S, 1,148R, 1,184D, 1,186K, 1,187P, 1,188E, 1,189N, 1,191L, 1,201V, 1,202D, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)
polypeptide substr...

1,069G

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,070S

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,184D

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,186K

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,187P

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,188E

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,205A

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,269M

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,270I

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,271G

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,272T

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,274M

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,304E

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)

1,313A

polypeptide substrate binding site
1,069G, 1,070S, 1,184D, 1,186K, 1,187P, 1,188E, 1,205A, 1,269M, 1,270I, 1,271G, 1,272T, 1,274M, 1,304E, 1,313A
CDD
cd06626 (STKc_MEKK4)
activation loop (A...

1,201V

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,202D

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,203F

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,204G

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,205A

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,206A

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,207K

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,208V

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,209I

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,252S

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,268S

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,269M

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,270I

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,271G

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,272T

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,273P

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

1,274M

activation loop (A-loop)
1,201V, 1,202D, 1,203F, 1,204G, 1,205A, 1,206A, 1,207K, 1,208V, 1,209I, 1,252S, 1,268S, 1,269M, 1,270I, 1,271G, 1,272T, 1,273P, 1,274M
CDD
cd06626 (STKc_MEKK4)

Protein sequence

>MIA_02990_1
METNNQPLDIINKDPRPSLKDSRVLQSSFKPNASSPLSPSSSSTSSNRLKPSSPTSSSHSRSTSFSTKPSQRPSLISAKS
YEARPHPHNQQRVSFDLYPSVADFKPPSSPSSSSPRSSASSRHNHPPSSPLGPSSSALTSPIATGSPPLLSRSKSFLANS
LNGSNGPNTSSGSSNSNSSSINSSSSEASNRYYAQEKGYLQYIQKDSYDSYSFRRIGLLDSDSDSDDDSDLSEVTGLSGM
GATFGDDYADTLSSYSFLESNQMTPGYDENLHERLEWQAMLASVLTGDVVTSEKNRLKTGGAIMKEDDVWIGIRARMCGR
TLDAQKKIIEESRSTVDNTLKEIMKFTATDPTNFDLCREEVHEVLDRIEQCEMLWTSTQAFKANSAIYRDDTFQRMLDAL
NTWVNITERVTEEVHLLRRWAGNDEMDPHKPFSDMVVDMSTIAEHILKSEDPQEIFRTQLEKHIEPVIISAREGLAEYGA
EMRALGLPIQRAGLQMLISFPVNLIHEIIRSSLAFSKGMSNPTMMLIDKNIEDITLYLNIAYMIKERTNSYIQPLDEVNW
VDCTPDAAFDKSILECIEYFFVLSQTKLSDTPIHHYGRGFKDIESLETQYAFLDRIARPIKDGRITVAMSSSLLASKMVN
NMLRYWDRQTAGPMMLNEAELQRWQSTTSEQVRKAQRKLLRFYQILSTNYKNAVEMSFQNTRLKALLDMLQDTNHFLVVP
TDFYQDAFIIASPGLIDRPGTIEGLLKGYYYDQEVESDLPYRPEYIILFRLEEPLTWEGPLVEMSFEAPDAVNPMDLQAG
RLRLVSEGGLHDLNTVREILAGQNISLDSFEVTADSISHQSKVNHELNRMRKLLYRTSISVISNTCKFRKKFKGYQEIVH
NMFVFAREFGQRGMNIMIPAWRSQLASELINLCIEWLSFICDDCVPTDLKTYRWTVVAIEFTMILTRGVNIIALSNDQFT
QLRLKVAGCMTLLILHFDIMGARSTAARQRNSRELTKRDNAAKFDLDLVEEFHRDTYKRITEMEGSWSQQNMGKVLDESD
SNLELVTYLVSNFSRMSIRWKQGRFIGAGSFGSVYTAVNLDTGGVMAVKEIRMQDPNSMRQALKQIRDEMTVLEMLRHPN
IVQYYGVEVHRDKVFLFMEYCQGGSLARLLECGRIEDETVIQVYTMQMLEGLAYLHQMGIVHRDVKPENVLLDHMGIIKF
VDFGAAKVIARRGQSRLATSSGEEAAAAAAAAVAAAAAASGGNGETSDAAPSSNTTGPPPATANRINSMIGTPMYMAPEV
ITGKCERGLQTAIDIWSLGCCVLEMATGRRPWANLDNEWAIMYHIAAGQLPQLPVSEQLSEFGIRFVERTLEREPRKRPT
ALMLLQDPWISMIRVSQGITTPGE

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component