MCA_02630_1

Protein

Length

1,385 amino acids

Gene name: SSK2

Description: MAP kinase kinase kinase Ssk2; in S. cerevisiae involved in HOG1 mitogen-activated signaling pathway

Browser: contigB:1877119-1881277+

RNA-seq: read pairs 1868, FPKM 16.7, percentile rank 36.5% (100% = highest expression)

Protein function

Annotation:		SSK2	MAP kinase kinase kinase Ssk2; in S. cerevisiae involved in HOG1 mitogen-activated signaling pathway
KEGG:	K11230	SSK2	mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
EGGNOG:	0PF9Z	SSK2	kinase kinase kinase
SGD closest match:	S000005314	SSK2	MAP kinase kinase kinase SSK2
CGD closest match:	CAL0000187689	SSK2	Mitogen-activated protein kinase kinase kinase

Protein alignments

	%id	Aln length	E-value
MIA_02990_1	61.26%	1208	0.0	MIA_02990_1
A0A0J9X2W6_GEOCN	54.61%	1117	0.0	Similar to Saccharomyces cerevisiae YCR073C SSK22 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway OS=Geotrichum candidum GN=BN980_GECA01s06082g PE=4 SV=1
UniRef50_A0A0J9XE87	53.61%	1192	0.0	Similar to Saccharomyces cerevisiae YNR031C SSK2 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XE87_GEOCN
A0A060T7T8_BLAAD	48.41%	1198	0.0	ARAD1C30382p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C30382g PE=4 SV=1
Q6CHT2_YARLI	40.92%	1190	0.0	YALI0A05247p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A05247g PE=4 SV=1
A0A1E3PQ57_9ASCO	48.47%	852	0.0	Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81915 PE=4 SV=1
A0A1D8PM87_CANAL	38.51%	1275	0.0	Mitogen-activated protein kinase kinase kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SSK2 PE=4 SV=1
A0A167BWT7_9ASCO	56.12%	645	0.0	Mitogen-activated protein kinase kinase kinase SSK2 OS=Sugiyamaella lignohabitans GN=SSK2 PE=4 SV=1
SSK2_YEAST	44.98%	627	5e-157	MAP kinase kinase kinase SSK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SSK2 PE=1 SV=1
A0A1E4TKK1_9ASCO	49.88%	419	8e-125	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55972 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7420
Predicted cleavage: 33

Protein family membership

None predicted.

Domains and repeats

Domain
1,049 - 1,351
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 200 400 600 800 1000 1200 1385

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,049 - 1,351
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  1,050 - 1,336
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. PF00069 (Pkinase)
  
  1,051 - 1,336
  
  Pfam
  PF00069 (Pkinase)
3. SM00220 (serkin_6)
  
  1,050 - 1,336
  
  SMART
  SM00220 (serkin_6)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  1,056 - 1,079
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  1,170 - 1,182
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

Coil

1,002 - 1,022

COILS
Coil (Coil)

1,380 - 1,385

COILS
Coil (Coil)
G3DSA:1.10.51...

1,159 - 1,346

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

1,035 - 1,158

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd06626 (STKc_MEKK4)

1,049 - 1,336

CDD
cd06626 (STKc_MEKK4)
mobidb-lite (disord...)

1,349 - 1,385

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 172

MobiDB Lite
mobidb-lite (disorder_prediction)

193 - 220

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,056I

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,057G

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,058G

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,059G

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,060S

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,064V

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,077A

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,079K

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,112V

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,128M

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,129E

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,130Y

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,131C

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,133G

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,134G

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,135S

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,138R

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,178E

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,179N

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,181L

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,191V

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,192D

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)

1,193F

ATP binding site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,133G, 1,134G, 1,135S, 1,138R, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,193F
CDD
cd06626 (STKc_MEKK4)
active site cd06626

1,056I

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,057G

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,058G

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,059G

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,060S

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,064V

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,077A

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,079K

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,112V

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,128M

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,129E

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,130Y

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,131C

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,134G

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,135S

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,138R

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,174D

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,176K

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,177P

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,178E

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,179N

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,181L

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,191V

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,192D

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,195A

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,234M

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,235I

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,236G

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,237T

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,239M

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,269E

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,278A

active site
1,056I, 1,057G, 1,058G, 1,059G, 1,060S, 1,064V, 1,077A, 1,079K, 1,112V, 1,128M, 1,129E, 1,130Y, 1,131C, 1,134G, 1,135S, 1,138R, 1,174D, 1,176K, 1,177P, 1,178E, 1,179N, 1,181L, 1,191V, 1,192D, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)
polypeptide substr...

1,059G

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,060S

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,174D

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,176K

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,177P

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,178E

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,195A

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,234M

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,235I

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,236G

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,237T

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,239M

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,269E

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)

1,278A

polypeptide substrate binding site
1,059G, 1,060S, 1,174D, 1,176K, 1,177P, 1,178E, 1,195A, 1,234M, 1,235I, 1,236G, 1,237T, 1,239M, 1,269E, 1,278A
CDD
cd06626 (STKc_MEKK4)
activation loop (A...

1,191V

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,192D

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,193F

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,194G

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,195A

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,196A

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,197K

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,198V

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,199I

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,200A

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,233S

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,234M

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,235I

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,236G

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,237T

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,238P

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

1,239M

activation loop (A-loop)
1,191V, 1,192D, 1,193F, 1,194G, 1,195A, 1,196A, 1,197K, 1,198V, 1,199I, 1,200A, 1,233S, 1,234M, 1,235I, 1,236G, 1,237T, 1,238P, 1,239M
CDD
cd06626 (STKc_MEKK4)

Protein sequence

>MCA_02630_1
MKRTSNNSNQPVISGASNSTRARSFSSSSSRAQSPSLQPSNSFDLASKPSGNRVSFDLYPSSIDVSHKPSNLNHQRKSSF
SSASPPPPTHQASSSSSSTASYISTRLSNSITNNHSHSTSSIPSIKRSSSTHHMPSNGHSRGSKSQLAQAGPSSTPTNRS
STPSNGYNNYDGTSKYYAQESAYLKKIENDKSKNDTFKLPGIPDPESDSEEESDLSDAGALGGLGTSFDASNISNYSFFE
ATDKSLRFNDFESLHERLEWQAMLTAVLTGDVIASEKIRLSKGGKAIQEDDVLIGLRARICGRTIEQQKRIFEDNRSNVD
TVLKEVMDFRVSDPKNIELCREEVKGVLHKVEQCEMLWISCKAFRKRCDSYNDPKFQRRMEALNAWHNVIGRIDEQVKLL
RKWTGNDEIDPTKPSDTKNHSTISEPTTLADRILKQKDPEDLFKTKLEKNIEPVVTAARNSFVEYSEDMEIVGLPLQKKG
LEIIISFLMILIHEIIRSRLEFSQKMSNPSPMLTNQTMEDISLYLKIASIVKERTASYIAPLTNGAQWVDFQPDPEFDKS
ILACIEYFFQLSESKLLATPVHYYGRAFKDIETLENQYMFLDSVSKQIKGGRSVVATLSSSLASKMVTSIIKYWERQKTG
PVLFNETECQRWQSSTTEQVRKAHRKLLRFYHILSTNYENSAEFSFHTDRFKILFNSLTKTNHFLVIPTQSSNQDVFVIA
EKSLANDPTAIAELLQGYSHKGDFNSEKEIEAPKYLIVFKLTEPLAWEGDLIEVPIENIEIELDPGRMRLVCEGGAQELI
QVRKNLKNDSISLDNFEVINPSFSSLSTVDNELNRMKRFLYKLSATVISDTCHFRKTFKDYPDIVQNMFMFAKDFGQRGI
NLMNKSRKGNIAFRLGNLCIEWLSFICDDCVPTDLKTYRWTVTAIEFTLLLTQGVNIIALSNEQFTQLRLRVAGCMTLLI
LHFDIMGARSTAARIQRQTRENKPNAKDSNVQDDSVLLEEFHRDAYKRLALMEENLRSQQNKGKVLDESDSNAELVTYLA
SNFSRMSIRWQQGQFIGGGSFGSVYTAMDLDSGEIMAVKEIRMQDPNSMRQALKSIKDEMTVLEMLHHPNIVHYFGVEVH
RDRVFIFMEYCQGGSLARLLEYGRIEDESVVQVYTMQMLEGLAYLHQKGVVHRDVKPENVLLDHMGIIKFVDFGAAKVIA
KRGQSRHGNGNFLSSINKSRSDGENNATTKLNSMIGTPMYMSPEVITGKCEKNLQSSIDIWSLGCCVLEMATGRRPWANL
DNEWAIMYHIAAGHLPQLPACPDQLSELGIQFLLRALEREPRNRPTAMTLLQDPWISMIRVSQGIENPNAQQLAGTPPTP
PISSNNTPSISTSLSSPSFMQQQQQ

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component