Protein

MIA_02939_1

Length
515 amino acids

Browser: contig03:2151233-2152781+

Protein function

EGGNOG:0PMDRKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)
CGD closest match:CAL0000177837orf19.2281Succinyl-CoA:3-ketoacid-coenzyme A transferase

Protein alignments

%idAln lengthE-value
MCA_03460_178.501%5070.0MCA_03460_1
A0A0J9YH80_GEOCN68.313%4860.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Geotrichum candidum GN=BN980_GECA01s00538g PE=3 SV=1
A0A060T3E9_BLAAD59.336%4820.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36850g PE=3 SV=1
UniRef50_I8A2T056.495%4850.0Succinyl-CoA:3-ketoacid-coenzyme A transferase n=4 Tax=Aspergillus TaxID=5052 RepID=I8A2T0_ASPO3
Q6C098_YARLI57.347%4900.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26587g PE=3 SV=1
A0A167DFS0_9ASCO56.442%4890.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Sugiyamaella lignohabitans GN=AWJ20_1147 PE=3 SV=1
Q59Z19_CANAL54.979%4826.78e-180Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2281 PE=3 SV=1
A0A1E4TET3_9ASCO52.967%4552.93e-165Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_104292 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9990
Predicted cleavage: 31

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 515

Detailed signature matches

  1. Family IPR004165
    Coenzyme A transferase family I
    1. PF01144 (CoA_trans)
    2. SM00882 (CoA_trans_3)
  2. Family IPR014388
    3-oxoacid CoA-transferase
    1. PIRSF000858 (SCOT-t)
  3. Domain IPR012791
    3-oxoacid CoA-transferase, subunit B
    1. TIGR02428
  4. SITE IPR004164
    Coenzyme A transferase active site
    1. PS01274 (COA_TRANSF_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.10...
  2. SSF100950 (NagB/Rpi...)

Protein sequence

>MIA_02939_1
MNSLICSRLTFTKSSARLLARSFASSAPRAKISKILGSTDEAVAKSGLKSGDIVLAGGFGLCGIPDTIIDSILKQKDSIR
DLTIVSNNAGVDGKGLGKLLNSGQVSKAIVSYIGENKFFEKLYLTGVISLQLTPQGTIAERLKAAASGVPAFYTPAALNT
VVEHGELPIKYNPDGTVQIYSEEKETRIFDGKRYLLEHALVGDVGIIKAYKADRLGNCVFHSTAHNFNGVMARAAKMTIV
EADHIVEVGELSPNEITIPGIYVNYVVQSLNPHQFERLEFAKDAAEVEHHDLSHMSKKEKIARRAALEFKEGMYVNLGIG
VPIMAASYADPNIDMQLQSENGVLGLGGLPKPGEEDPDTISAGKAAATLTKGAAVFGSEESFAMIRAGKMDMAMLGAMEV
SKDGDLANWFIPGKVKGMGGAMDLVANPEKTRVVVCTDHVDKFGRPKIVEECSLPLTGAKVVSRIISDMAVFDVDHNSGL
LLREVAPGLTVDDIKAATGTSFQVADDLKTIEYAP

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0046952 ketone body catabolic process

Molecular Function

GO:0008410 CoA-transferase activity

Cellular Component

None predicted.