Protein

MCA_03460_1

Length
513 amino acids

Description: belongs to Coenzyme A transferase family 1

Browser: contigC:34146-35822-

RNA-seq: read pairs 717, FPKM 17.2, percentile rank 37.3% (100% = highest expression)

Protein function

Annotation:belongs to Coenzyme A transferase family 1
KEGG:K01027OXCT 3-oxoacid CoA-transferase [EC:2.8.3.5]
EGGNOG:0PMDRKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)
CGD closest match:CAL0000177837orf19.2281Succinyl-CoA:3-ketoacid-coenzyme A transferase

Protein alignments

%idAln lengthE-value
MIA_02939_178.50%5070.0MIA_02939_1
A0A0J9YH80_GEOCN68.06%5010.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Geotrichum candidum GN=BN980_GECA01s00538g PE=3 SV=1
A0A060T3E9_BLAAD60.33%4890.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36850g PE=3 SV=1
UniRef50_I8A2T054.14%4950.0Succinyl-CoA:3-ketoacid-coenzyme A transferase n=4 Tax=Aspergillus TaxID=5052 RepID=I8A2T0_ASPO3
Q6C098_YARLI55.86%5120.0Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F26587g PE=3 SV=1
A0A167DFS0_9ASCO54.38%5022e-180Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Sugiyamaella lignohabitans GN=AWJ20_1147 PE=3 SV=1
Q59Z19_CANAL53.73%4822e-179Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2281 PE=3 SV=1
A0A1E4TET3_9ASCO53.64%4532e-168Succinyl-CoA:3-ketoacid-coenzyme A transferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_104292 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9967
Predicted cleavage: 30

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 513

Detailed signature matches

  1. Family IPR004165
    Coenzyme A transferase family I
    1. PF01144 (CoA_trans)
    2. SM00882 (CoA_trans_3)
  2. Family IPR014388
    3-oxoacid CoA-transferase
    1. PIRSF000858 (SCOT-t)
  3. Domain IPR012792
    3-oxoacid CoA-transferase, subunit A
    1. TIGR02429
  4. Domain IPR012791
    3-oxoacid CoA-transferase, subunit B
    1. TIGR02428
  5. SITE IPR004164
    Coenzyme A transferase active site
    1. PS01274 (COA_TRANSF_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.10...
  2. SSF100950 (NagB/Rpi...)

Protein sequence

>MCA_03460_1
MLATNYRIVFTRSTTKIIFRGFASTSYRAQISKIVSSADEAVEKSGLKTGDTILAGGFGLCGIPDSTIDAILRKKDTISD
LTIVSNNAGVDGKGLGKLLNSGQVSQAIVSYIGENKFFENLYSSGKITLQLTPQGTIAERIKAAASGVPAFYTPAALNTA
VEYGELPIRYNSDGTVKTYSETKETRIFNGKKYLLEHALPGDVSIVKVHKADRLGNAVFHSTAHNFNGVMARASTRTIVE
ADEIVEVGELGPNEIAVPGIYVDYVFKTTNPRQFERLEFAKDDSKLEHHEINDMSKKEKIARRAALEFEEGMYVNLGIGV
PIMAASYVDKSIDIQLQSENGVLGLGGLPRPGEEDPDTISAGKAAATLTPGASVFGSEESFAMIRSGRMDMAMLGAMQVS
RKGDLANWFLPGKVKGMGGAMDLVANPDKTRVVVCCDHTDKAGNPKIMEECDLPLTGKQVVSRIITDMAVFDVNHATGLI
LKEIAPGLTVEDIKKSTGCSFDVCPDLKIIEYA

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0046952 ketone body catabolic process

Molecular Function

GO:0008410 CoA-transferase activity

Cellular Component

None predicted.