MIA_02937_1

Protein

Length

511 amino acids

Protein function

EGGNOG:	0PJXX	FG05448.1	transporter

Protein alignments

	%id	Aln length	E-value
MCA_03462_1	54.038%	520	2.83e-170	MCA_03462_1
A0A0J9YH97_GEOCN	45.908%	501	1.12e-136	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s01198g PE=4 SV=1
UniRef50_A0A0J9XAQ4	46.707%	501	9.98e-133	Uncharacterized protein n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAQ4_GEOCN
A0A060T046_BLAAD	43.333%	480	4.27e-116	ARAD1C13750p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C13750g PE=4 SV=1
A0A167CTU0_9ASCO	38.799%	433	6.91e-102	Membrane transporter OS=Sugiyamaella lignohabitans GN=AWJ20_331 PE=4 SV=1
Q6C4M8_YARLI	39.792%	480	1.07e-93	YALI0E25179p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E25179g PE=4 SV=1
A0A1E3PD64_9ASCO	35.676%	370	2.37e-73	MFS general substrate transporter (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84412 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1152

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
39 - 503
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 511

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  54 - 427
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  49 - 503
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  39 - 253
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  289 - 498
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  53 - 498
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

228 - 298

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

362 - 372

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

497 - 511

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

171 - 176

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 47

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

422 - 441

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

114 - 119

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

292 - 500

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

43 - 245

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

75 - 93

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

322 - 340

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

465 - 475

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

198 - 208

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

140 - 150

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

392 - 396

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

53 - 75

TMHMM
TMhelix (TMhelix)

207 - 229

TMHMM
TMhelix (TMhelix)

88 - 110

TMHMM
TMhelix (TMhelix)

368 - 387

TMHMM
TMhelix (TMhelix)

449 - 471

TMHMM
TMhelix (TMhelix)

120 - 139

TMHMM
TMhelix (TMhelix)

307 - 329

TMHMM
TMhelix (TMhelix)

478 - 500

TMHMM
TMhelix (TMhelix)

336 - 358

TMHMM
TMhelix (TMhelix)

400 - 422

TMHMM
TMhelix (TMhelix)

178 - 200

TMHMM
TMhelix (TMhelix)

146 - 168

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

442 - 464

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

177 - 197

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

94 - 113

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

209 - 227

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

397 - 421

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

120 - 139

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

476 - 496

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

341 - 361

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

48 - 74

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

373 - 391

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

299 - 321

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

151 - 170

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

64Y

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

67I

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

68V

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

69P

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

71V

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

72P

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

94L

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

97Y

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

98S

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

101L

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

105S

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

106V

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

108F

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

109G

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

156A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

157A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

160W

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

161V

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

164L

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

165A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

168A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

180M

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

181S

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

184G

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

185M

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

191M

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

319A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

322M

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

323T

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

326E

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

327S

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

330T

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

344S

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

348F

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

352A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

355S

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

358E

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

407L

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

410A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

411G

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

414V

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

418F

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

419A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

422T

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

449A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

450Y

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

453F

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

454N

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

457Y

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

458A

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

461S

putative substrate translocation pore
64Y, 67I, 68V, 69P, 71V, 72P, 94L, 97Y, 98S, 101L, 105S, 106V, 108F, 109G, 156A, 157A, 160W, 161V, 164L, 165A, 168A, 180M, 181S, 184G, 185M, 191M, 319A, 322M, 323T, 326E, 327S, 330T, 344S, 348F, 352A, 355S, 358E, 407L, 410A, 411G, 414V, 418F, 419A, 422T, 449A, 450Y, 453F, 454N, 457Y, 458A, 461S
CDD
cd06174 (MFS)

Protein sequence

>MIA_02937_1
MSKAVLEDFETNISSTPLEHKPTRELRPTQMPVFSYEQVLLLRGSVPLIVGSVSFATFADIFIYSIIVPVVPYVLESRLG
IAESSVQHSTSKILALYSVGLIVGSVVFGYVADRLKHRRLIMLLGLLILVGATLILFFARSMALYMVGRVIQGLSAATVW
VVGLAIVADVGDSSNMAFLMSFPGMGLSFGMFLGPLVGGVVYERAGYNSVFYVCFGVLAVDILLRIIMLERSHMLELCAE
RAEKLAAASQGLSAAQEEFVRVYYRNRPPQPSPEASPEGEPAAPFTVTLFKRTIRIPTYLGLLGDVRILNAFYLSIVLAW
IMTAFESILTLHVEEVFGFSALQSGLLFIAFAGPSLFEPVVGRLSDRLGPRRIVFCGFMLATPALILMRLADHEKSAGRV
ACLSVLLVAAGLCVSTIFAPVTSEFSNAVAEMDERRPGLLGAGRGFGQAYGLFNVAYALGSLIGPFEAGGIAESHGWGAA
VLSLGIVTFVSGLVTYPFTGGVLKRGEVFRW

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features