MCA_03462_1

Protein

Length

564 amino acids

RNA-seq: read pairs 1065, FPKM 23.3, percentile rank 45.5% (100% = highest expression)

Protein function

EGGNOG:	0PJXX	FG05448.1	transporter

Protein alignments

	%id	Aln length	E-value
MIA_02937_1	54.81%	520	2e-175	MIA_02937_1
A0A0J9YH97_GEOCN	46.57%	539	7e-143	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s01198g PE=4 SV=1
UniRef50_A0A0J9XAQ4	45.49%	532	2e-136	Uncharacterized protein n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAQ4_GEOCN
A0A060SZU6_BLAAD	46.03%	504	3e-134	ARAD1C11352p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C11352g PE=4 SV=1
A0A167CTU0_9ASCO	37.53%	469	8e-106	Membrane transporter OS=Sugiyamaella lignohabitans GN=AWJ20_331 PE=4 SV=1
Q6C4M8_YARLI	41.24%	502	1e-100	YALI0E25179p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E25179g PE=4 SV=1
A0A1E3PD64_9ASCO	40.25%	400	4e-91	MFS general substrate transporter (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84412 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0194

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
69 - 550
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 564

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  74 - 476
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  69 - 550
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  338 - 546
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  70 - 264
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  73 - 545
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 68

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

473 - 492

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

414 - 419

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

188 - 198

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

250 - 345

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

546 - 564

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

134 - 139

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

340 - 555

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

57 - 292

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

160 - 164

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

218 - 228

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

371 - 389

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

440 - 444

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

95 - 113

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

512 - 522

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

349 - 371

TMHMM
TMhelix (TMhelix)

195 - 217

TMHMM
TMhelix (TMhelix)

227 - 249

TMHMM
TMhelix (TMhelix)

110 - 132

TMHMM
TMhelix (TMhelix)

391 - 413

TMHMM
TMhelix (TMhelix)

73 - 95

TMHMM
TMhelix (TMhelix)

137 - 159

TMHMM
TMhelix (TMhelix)

497 - 519

TMHMM
TMhelix (TMhelix)

529 - 551

TMHMM
TMhelix (TMhelix)

443 - 465

TMHMM
TMhelix (TMhelix)

420 - 439

TMHMM
TMhelix (TMhelix)

169 - 188

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

420 - 439

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

445 - 472

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

114 - 133

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

199 - 217

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

140 - 159

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

165 - 187

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

523 - 545

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

493 - 511

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

69 - 94

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

229 - 249

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

346 - 370

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

390 - 413

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 24

MobiDB Lite
mobidb-lite (disorder_prediction)

284 - 326

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

84Y

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

87V

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

88V

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

89P

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

91F

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

92P

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

114L

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

117Y

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

118S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

121L

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

125S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

126I

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

128F

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

129G

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

176A

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

177S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

180W

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

181V

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

184L

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

185A

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

188A

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

200M

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

201G

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

204G

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

205I

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

211L

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

367A

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

370L

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

371T

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

374E

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

375G

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

378T

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

392A

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

396F

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

400A

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

403S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

406E

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

458G

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

461N

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

462S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

465F

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

469T

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

470A

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

473S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

496V

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

497Y

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

500F

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

501N

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

504Y

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

505S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

508S

putative substrate translocation pore
84Y, 87V, 88V, 89P, 91F, 92P, 114L, 117Y, 118S, 121L, 125S, 126I, 128F, 129G, 176A, 177S, 180W, 181V, 184L, 185A, 188A, 200M, 201G, 204G, 205I, 211L, 367A, 370L, 371T, 374E, 375G, 378T, 392A, 396F, 400A, 403S, 406E, 458G, 461N, 462S, 465F, 469T, 470A, 473S, 496V, 497Y, 500F, 501N, 504Y, 505S, 508S
CDD
cd06174 (MFS)

Protein sequence

>MCA_03462_1
MSESNILSSTLSGQTPEDKNHKTQDILAIKDKRQATTIENTQEINDSPIALKPFSLEWITEIRGSTAMIVGSISFAVFTD
IFVYSVVVPVFPYVLQTRLGVSLDDLQNRVSQILALYSVGLIVGSILFGYIADKIPFRRLIMLIGLLILTGSTLLIFFAK
SLPLYMVARVIQGLSASVVWVVGLAIVADIGDSTNIAYLMGYPGIGLSMGLFAGPLVGGIMYDRVGYNGVFYVCFGILAV
DIILRLIMIEKSHLREFRRKRAAKLAKKGIDSLSPELQEYVKRYNPDNNRPNSTTITTTCQETNEDDNYNDVERQHDASS
TSDPEKPSKPVCFYLNIFNKKFQIPAYFALLFNIRILNAFFLSIIMAWFLTAFEGILTIHLETTFHFNSLQAGLMFLAVA
GPSFAEPIIGYLCDKFGPRYIVAGGLVLATPAFICLRFVDHNTAGQIALISVLLVIIGLCNSAIFAPVTAEFSNAVSKFE
SRNPGSLGKGKGFGQVYGIFNVGYSIGSLIGPFEAGGVVTSRGWGMAVLSLGLVSIISAFVTFPFTGGNLLKKRFPKSHV
TLEM

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features