Protein

MIA_02936_1

Length
467 amino acids

Browser: contig03:2141460-2142864-

Protein function

EGGNOG:0PHAUESA1Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac
SGD closest match:S000005770ESA1Histone acetyltransferase ESA1
CGD closest match:CAL0000179231ESA1Histone acetyltransferase ESA1

Protein alignments

%idAln lengthE-value
MCA_06395_176.835%4360.0MCA_06395_1
A0A0J9X6P2_GEOCN69.955%4460.0Histone acetyltransferase OS=Geotrichum candidum GN=BN980_GECA03s07974g PE=3 SV=1
A0A167C1V8_9ASCO66.234%4620.0Histone acetyltransferase OS=Sugiyamaella lignohabitans GN=ESA1 PE=3 SV=1
A0A060TD78_BLAAD67.500%4400.0Histone acetyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D40832g PE=3 SV=1
ESA1_YARLI68.046%4350.0Histone acetyltransferase ESA1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ESA1 PE=3 SV=1
A0A1E3PD09_9ASCO66.359%4340.0Histone acetyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48183 PE=3 SV=1
UniRef50_A0A1D2VI3963.657%4320.0Histone acetyltransferase (Fragment) n=19 Tax=Ascomycota TaxID=4890 RepID=A0A1D2VI39_9ASCO
ESA1_YEAST62.500%4320.0Histone acetyltransferase ESA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ESA1 PE=1 SV=1
A0A1E4TC75_9ASCO59.775%4450.0Histone acetyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_138326 PE=3 SV=1
ESA1_CANAL54.150%5062.11e-176Histone acetyltransferase ESA1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ESA1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0033

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 467

Detailed signature matches

  1. Domain IPR016197
    Chromo domain-like
    1. SSF54160 (Chromo do...)
  2. Domain IPR000953
    Chromo/chromo shadow domain
    1. SM00298 (chromo_7)
  3. Domain IPR025995
    RNA binding activity-knot of a chromodomain
    1. PF11717 (Tudor-knot)
  4. Domain IPR016181
    Acyl-CoA N-acyltransferase
    1. SSF55729 (Acyl-CoA ...)
  5. Domain IPR002717
    Histone acetyltransferase domain, MYST-type
    1. PS51726 (MYST_HAT)
    2. PF01853 (MOZ_SAS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.30.30...
  2. G3DSA:3.30.60.60
  3. G3DSA:3.40.63...
  4. cd00024 (CHROMO)
  5. cd04301 (NAT_SF)
  6. mobidb-lite (disord...)

Residue annotation

  1. histone binding si...
  2. Coenzyme A binding...

Protein sequence

>MIA_02936_1
MDPPQQQQQPATTGSTTAPPAAPPATDPSLALTHAVLPIGAKVYVQKDGEKRQAEVLARQPKRSGMLTFYVHYVEFNKRL
DEWVPETRIDLTMPVLLPKQGKKAVGAHASPASAAPSSSGPKKKTSARNHHNTNSDTIDLEDAANALNGSPAGGRPYDRG
QEIEKLRTSGSMTQNALEVSRVKNISRIIMGEHEVEPWYFSPYPVELTEVDIIYICEFTLSYFASRKQFERFRSKTTLRH
PPGNEIYRDDRVSFFEIDGRKQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTRRDDMGHHLVGYFSKEKESAEGYNV
ACILTLPQYQRHGYGRILIDFSYALSKRESKFGSPEKPLSDLGLLSYRAYWADTVIELLVENSKSGKTETTIEDIASITA
MTTTDILHTLGALNMLKYYKGQHIICLTDALVDKYEREKAKKRHRIDSSLLKWKPPVFSASQLRFGW

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.