Protein

MCA_06395_1

Length
462 amino acids

Gene name: ESA1

Description: Histone acetyltransferase ESA1

Browser: contigD:4090018-4091407-

RNA-seq: read pairs 562, FPKM 15.0, percentile rank 34.1% (100% = highest expression)

Protein function

Annotation:ESA1Histone acetyltransferase ESA1
KEGG:K11304TIP60 histone acetyltransferase HTATIP [EC:2.3.1.48]
EGGNOG:0PHAUESA1Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac
SGD closest match:S000005770ESA1Histone acetyltransferase ESA1
CGD closest match:CAL0000179231ESA1Histone acetyltransferase ESA1

Protein alignments

%idAln lengthE-value
MIA_02936_176.83%4360.0MIA_02936_1
A0A0J9X6P2_GEOCN71.55%4710.0Histone acetyltransferase OS=Geotrichum candidum GN=BN980_GECA03s07974g PE=3 SV=1
A0A060TD78_BLAAD66.37%4550.0Histone acetyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D40832g PE=3 SV=1
ESA1_YARLI67.32%4590.0Histone acetyltransferase ESA1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ESA1 PE=3 SV=1
A0A1E3PD09_9ASCO64.14%4490.0Histone acetyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48183 PE=3 SV=1
A0A167C1V8_9ASCO81.79%3130.0Histone acetyltransferase OS=Sugiyamaella lignohabitans GN=ESA1 PE=3 SV=1
ESA1_YEAST62.22%4420.0Histone acetyltransferase ESA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ESA1 PE=1 SV=1
UniRef50_Q0864962.22%4420.0Histone acetyltransferase ESA1 n=62 Tax=Saccharomycetales TaxID=4892 RepID=ESA1_YEAST
A0A1E4TC75_9ASCO58.89%4670.0Histone acetyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_138326 PE=3 SV=1
ESA1_CANAL53.39%5022e-167Histone acetyltransferase ESA1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ESA1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0688

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 462

Detailed signature matches

  1. Domain IPR016197
    Chromo domain-like
    1. SSF54160 (Chromo do...)
  2. Domain IPR000953
    Chromo/chromo shadow domain
    1. SM00298 (chromo_7)
  3. Domain IPR025995
    RNA binding activity-knot of a chromodomain
    1. PF11717 (Tudor-knot)
  4. Domain IPR016181
    Acyl-CoA N-acyltransferase
    1. SSF55729 (Acyl-CoA ...)
  5. Domain IPR002717
    Histone acetyltransferase domain, MYST-type
    1. PS51726 (MYST_HAT)
    2. PF01853 (MOZ_SAS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.30.30...
  2. G3DSA:3.30.60.60
  3. G3DSA:3.40.63...
  4. cd00024 (CHROMO)
  5. cd04301 (NAT_SF)
  6. mobidb-lite (disord...)

Residue annotation

  1. histone binding si...
  2. Coenzyme A binding...

Protein sequence

>MCA_06395_1
MKEETPSTTSTQNGSAKNSPAPAITMATNITPSSIPIGTKIYVEKDGEKRQAEILARQPKKNILSFYVHYVEFNKRLDEW
VTEERLDLTMPVEWPKPEKPKKTSTPTPSSTQKTSKAANNKRKKDGKADTPDDDIHIDVDAININGTTTETYNRGQEIKR
LRTGGSMTQNLAEVSRVKNISRIIMGEHEVEPWYFSPYPIELSEESHIYICEFTLSYFGSQKQFERFRSKSTLRHPPGNE
IYRDEKVSFFEIDGRKQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTRRDEVGHHLVGYFSKEKESAEGYNVACILT
LPQYQRHGYGRILIDFSYNLSKRENRLGSPEKPLSDLGLLSYRAYWADTVIELLIENSRAGKTETTIEDIASFTSMTTTD
ILHTLGALNMLKYYKGQHIICLTEALVDKYEREKAKKRHRIDATKLIWKPPVFTPAQLRFAW

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.