Protein

MIA_02881_1

Length
546 amino acids

Browser: contig03:1995019-1997127+

Protein function

EGGNOG:0PFSMATP1Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
SGD closest match:S000000195ATP1ATP synthase subunit alpha, mitochondrial
CGD closest match:CAL0000188156ATP1ATP synthase subunit alpha

Protein alignments

%idAln lengthE-value
MCA_04784_192.491%5460.0MCA_04784_1
A0A0J9X6M3_GEOCN89.358%5450.0ATP synthase subunit alpha OS=Geotrichum candidum GN=BN980_GECA04s00593g PE=3 SV=1
A0A1E3PIP2_9ASCO84.404%5450.0ATP synthase subunit alpha OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_25413 PE=3 SV=1
Q6C326_YARLI85.106%5170.0ATP synthase subunit alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F03179g PE=1 SV=1
A0A060T1H4_BLAAD83.119%5450.0ATP synthase subunit alpha OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C16500g PE=3 SV=1
A0A1D8PDC4_CANAL83.946%5170.0ATP synthase subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATP1 PE=3 SV=1
ATPA_YEAST85.437%5150.0ATP synthase subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATP1 PE=1 SV=5
UniRef50_P0725185.437%5150.0ATP synthase subunit alpha, mitochondrial n=329 Tax=cellular organisms TaxID=131567 RepID=ATPA_YEAST
A0A1E4THU0_9ASCO82.979%5170.0ATP synthase subunit alpha OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32002 PE=3 SV=1
A0A167EJC4_9ASCO86.577%4470.0ATP synthase subunit alpha OS=Sugiyamaella lignohabitans GN=ATP1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9977
Predicted cleavage: 43

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 500 546

Detailed signature matches

  1. Family IPR005294
    ATP synthase, F1 complex, alpha subunit
    1. MF_01346 (ATP_synth...)
    2. PIRSF039088 (F_ATPa...)
    3. TIGR00962
  2. Domain IPR023366
    ATP synthase subunit alpha-like domain
    1. G3DSA:2.40.30.20
  3. Domain IPR004100
    ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
    1. SSF50615 (N-termina...)
    2. PF02874 (ATP-synt_ab_N)
  4. Domain IPR000194
    ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
    1. PF00006 (ATP-synt_ab)
  5. Domain IPR033732
    ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
    1. cd01132 (F1_ATPase_...)
  6. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  7. Domain IPR000793
    ATP synthase, alpha subunit, C-terminal
    1. PF00306 (ATP-synt_ab_C)
  8. SITE IPR020003
    ATPase, alpha/beta subunit, nucleotide-binding domain, active site
    1. PS00152 (ATPASE_ALP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.15...
  2. G3DSA:3.40.50...
  3. SSF47917 (C-termina...)

Residue annotation

  1. beta subunit inter...
  2. Walker A motif cd0...
  3. ATP binding site c...
  4. Walker B motif cd0...

Protein sequence

>MIA_02881_1
MLRTVLRQSTRRAGVAAAQRFAAATPRVVVSTRGFAEAKATPTEVSSILEERIRGVSGEADLNETGRVLSVGDGIARVFG
LNNVQAEELVEFSSGVKGMALNLEAGQVGIVLFGSDRLVKEGETVKRTGSIVDVPVGPGLLGRVVDALGNPIDAKGPIES
TERIRAQVKAPGILPRRSVHEPMQTGLKSVDALVPIGRGQRELIIGDRQTGKTTVAVDTILNQKRWNTLSDESKKLYCVY
VAVGQKRSTVAQLVQTLEQNDALKYSIIVAATASEAAPLQYLAPFTGCAIGEWFRDNGKHALIIYDDLSKQAVAYRQMSL
LLRRPPGREAYPGDVFYLHSRLLERAAKMSEKHGSGSLTALPVIETQGGDVSAYIPTNVISITDGQIFLEAELFYKGIRP
AINVGLSVSRVGSAAQVKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTKLTLARGERLTQILKQKQASPLGAEEQVP
VVFAGVNGFLDKVPVNDVARYEAELLSYLKSNESGILSAIAEKGELTKDQLAQLKEATATFSANFA

GO term prediction

Biological Process

GO:0015986 ATP synthesis coupled proton transport
GO:0015992 proton transport
GO:0046034 ATP metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0032559 adenyl ribonucleotide binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism

Cellular Component

GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)