MIA_02870_1

Protein

Length

1,729 amino acids

Browser: contig03:1965956-1971209+

Protein function

EGGNOG:	0PH3T		lysine-specific histone demethylase
SGD closest match:	S000004622	FMS1	Polyamine oxidase FMS1
CGD closest match:	CAL0000184027	CBP1	Corticosteroid-binding protein

Protein alignments

	%id	Aln length	E-value
MCA_02636_1	75.294%	765	0.0	MCA_02636_1
A0A0J9X793_GEOCN	66.040%	798	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA04s04168g PE=4 SV=1
UniRef50_A0A0J9X793	66.040%	798	0.0	Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X793_GEOCN
A0A060T2Z9_BLAAD	57.760%	741	0.0	ARAD1A12254p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12254g PE=4 SV=1
Q6C7M1_YARLI	51.816%	716	0.0	YALI0D26972p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D26972g PE=4 SV=1
A0A167D0C5_9ASCO	56.752%	548	0.0	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_573 PE=4 SV=1
CBP1_CANAL	27.564%	312	1.37e-13	Corticosteroid-binding protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CBP1 PE=1 SV=2
A0A1E3PNR5_9ASCO	22.826%	276	1.23e-11	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81687 PE=4 SV=1
FMS1_YEAST	23.936%	376	3.17e-08	Polyamine oxidase FMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FMS1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0057

Protein family membership

None predicted.

Domains and repeats

Domain
554 - 652
Homeobox domain-like (IPR009057)
SWIRM domain (IPR007526)
675 - 1,220
Amine oxidase (IPR002937)
1,498 - 1,601
High mobility group box domain (IPR009071)
Domain
559 - 648
Winged helix-turn-helix DNA-binding domain (IPR011991)
649 - 1,067
FAD/NAD(P)-binding domain (IPR023753)
1,157 - 1,228
FAD/NAD(P)-binding domain (IPR023753)

1 200 400 600 800 1000 1200 1400 1600 1729

Detailed signature matches

IPR009057

Homeobox domain-like
1. SSF46689 (Homeodoma...)
  
  554 - 649
  
  SUPERFAMILY
  SSF46689 (Homeodomain-like)
IPR007526

SWIRM domain
1. PF04433 (SWIRM)
  
  568 - 643
  
  Pfam
  PF04433 (SWIRM)
2. PS50934 (SWIRM)
  
  557 - 652
  
  PROSITE profiles
  PS50934 (SWIRM)
IPR011991

Winged helix-turn-helix DNA-binding domain
1. G3DSA:1.10.10.10
  
  559 - 648
  
  GENE3D
  G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
IPR023753

FAD/NAD(P)-binding domain
1. G3DSA:3.50.50.60
  
  1,157 - 1,228
  
  GENE3D
  G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
  
  649 - 987
  
  GENE3D
  G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
2. SSF51905 (FAD/NAD(P...)
  
  1,179 - 1,222
  
  SUPERFAMILY
  SSF51905 (FAD/NAD(P)-binding domain)
  
  665 - 1,067
  
  SUPERFAMILY
  SSF51905 (FAD/NAD(P)-binding domain)
IPR002937

Amine oxidase
1. PF01593 (Amino_oxidase)
  
  675 - 1,220
  
  Pfam
  PF01593 (Amino_oxidase)
IPR009071

High mobility group box domain
1. G3DSA:1.10.30.10
  
  1,498 - 1,601
  
  GENE3D
  G3DSA:1.10.30.10 (G3DSA:1.10.30.10)
2. PS50118 (HMG_BOX_2)
  
  1,505 - 1,585
  
  PROSITE profiles
  PS50118 (HMG_BOX_2)
3. SSF47095 (HMG-box)
  
  1,503 - 1,594
  
  SUPERFAMILY
  SSF47095 (HMG-box)

no IPR

Unintegrated signatures

Coil

1,574 - 1,601

COILS
Coil (Coil)

1,649 - 1,669

COILS
Coil (Coil)
G3DSA:3.90.66...

988 - 1,156

GENE3D
G3DSA:3.90.660.10 (G3DSA:3.90.660.10)
SSF54373 (FAD-linke...)

1,047 - 1,169

SUPERFAMILY
SSF54373 (FAD-linked reductases, C-terminal domain)
cd01390 (HMGB-UBF_H...)

1,504 - 1,596

CDD
cd01390 (HMGB-UBF_HMG-box)
mobidb-lite (disord...)

1,599 - 1,729

MobiDB Lite
mobidb-lite (disorder_prediction)

1,269 - 1,300

MobiDB Lite
mobidb-lite (disorder_prediction)

230 - 251

MobiDB Lite
mobidb-lite (disorder_prediction)

266 - 329

MobiDB Lite
mobidb-lite (disorder_prediction)

137 - 183

MobiDB Lite
mobidb-lite (disorder_prediction)

1,377 - 1,400

MobiDB Lite
mobidb-lite (disorder_prediction)

345 - 503

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

DNA binding site c...

1,506R

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,509A

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,510N

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,512F

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,513L

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,516Q

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,517K

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,520W

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,536E

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,549A

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,552G

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,555W

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

1,588A

DNA binding site
1,506R, 1,509A, 1,510N, 1,512F, 1,513L, 1,516Q, 1,517K, 1,520W, 1,536E, 1,549A, 1,552G, 1,555W, 1,588A
CDD
cd01390 (HMGB-UBF_HMG-box)

Protein sequence

>MIA_02870_1
MNNNDRNSKNMSSFSVANIMMPPDFPSNQNQFYSDQHKKPDEIQAAQQVDNNDKINRALFSNQVNLDNNMVSALQNLVQL
TDDENVTSNNINMSSSSSSFPDPARTDSYTKLGDATEDLLALPSTFDFFSNQGLNFPGQSSSSLPRNRAQNTIDNNPGQN
QYMDKKTEKQNNAGSRDILNPSISDPMFFMARSNSATSPSQSTQLLLQQQQQQQQQPLLLQQSTFSKNQGMTTFDSSLRD
GNSTRNAIDRNADKSNLWNMYEARVGVDSNNGGNNNKLKNTSSHRDENLHESNGSGHIFSLDKSSPFFSLSGESPQQSSM
LQSTQERPQTTQIQFFPQLQGQDRNQYSNSKIHGGNRQSTHGLPSTSSTSAHASPSSLNTPHAQGSQNYSIPLGQPNQHA
AQREKSRLSVSQTSHQAYEEYSRSLGHSSSRNTYSPDNVLSTKPNGLADYSSQQAVHQMQQQQQLHHQMQQQNHHYMHVP
NPHQVNPSSSASSASSSHHVVSPQALVSPSISDAGQGSYFSPPIPPHEAELMIIRQKYKAKSSIPADLSSANYGEQCVYA
AVSSRLPPFSLHPEEYNLLRPYLTVVHVTTYLNIRNGILRLWLSNPKVNVTRSEAAGCAKDDRFFNLAEVAYDWLVRHGR
INFGCFEYPSLDFYNPIPEECRKPRQTVVILGAGIAGLSCARQLDNLFQRKARHFSEYQDPPRIIVLEGRRRIGGRIYSA
HLKSDHLHAVDMGAQFIAGFGNGNPLAVVCRRQLGLPVTRINPMSEIYDSVSKKGVDRAMQERAQKLFKHLLERVAQFHN
RYSPPATAEGDEVLIRVSKDPPREDYPATLTLAKAEDSGRLGNDTSHRGEQEFKHHEEYRESLGRIEAQFLRDIGFALKP
EVSEDTSIQLIPEPQGDMYPSLGISMDALLRQLQEIANITPEELRLLNWHYANLEYVHSTCLDNLSLNNWKHEGTKFTGQ
HSVVKNGYMNLVRGLYQYPEKLEVRFKSNVKILEYSNSHVELFLENGERMKADKVVVTAPLGVLKDRTIQFIPDLPQWKQ
DSIERLGFGVVNKVCLVYKRAFWDENKHIIAISQSHRGLDALEQENYKNNRGMFYMFWNVSKAVGKPCLIGILTGEAAVQ
MANETDESIVEAATASIECVYSEVRDTTLVESIVTRWQVDPFSRGSYSYVGLEATPADYDLLARPIGESLFFAGEATSRS
YPATVHGAYISGLRAANEVLTSMIGEVKIPQPLCPSKDYQVNKRMQQNSVMVGGSSGLTSHVTPVGSMVSTPSGSTGMTT
TTTTADGSTGAAGPSANGSSANGITSIATTTTSSTTNAATAGVDGIPTGYGSAKAQRNVSGVVTTNSGNLVHLHHQPQFK
TKEFGGDTGMVHQGRNSRPITTSSGAPPINNANNNGNNHSGDPRIANNSMTLSRLGESGGFLGGSYGGARGLSQAAINSG
AVHGQTNSNTASGCGSGIGGGRAVPEENAVEVRLRQLREERLDADNDRMRIDMIKEIGERPIKPERSGANPFLIFQKDFW
DKCRKQCDVEKQKKMEDPHVRAARNEVRAALGKMWRELPEEEKKPYLEKTKFIKESNNKKSEEYREKARRYKTEVEEFRK
RWKEENASKPGEEEVRLQRMIQEERVQEKNRQQGRKGGGGDGGHEKKEVEAAEERRVRKRRRVKKEGEEDGEEDEEDEED
EGEEDGGEEIEGEDGRKRRRASRTNRTKTGRSDKRLGTSGEGSQGWRAC

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003677 DNA binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity

Cellular Component