MCA_02636_1

Protein

Length

1,571 amino acids

Description: lysine-specific histone demethylase

Browser: contigB:1911282-1916085-

RNA-seq: read pairs 3352, FPKM 26.3, percentile rank 49.0% (100% = highest expression)

Protein function

Annotation:			lysine-specific histone demethylase
KEGG:	K11450	KDM1A	lysine-specific histone demethylase 1A [EC:1.-.-.-]
EGGNOG:	0PH3T		lysine-specific histone demethylase
SGD closest match:	S000004622	FMS1	Polyamine oxidase FMS1
CGD closest match:	CAL0000184027	CBP1	Corticosteroid-binding protein

Protein alignments

	%id	Aln length	E-value
MIA_02870_1	75.13%	756	0.0	MIA_02870_1
A0A0J9X793_GEOCN	63.91%	798	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA04s04168g PE=4 SV=1
UniRef50_A0A0J9X793	63.91%	798	0.0	Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X793_GEOCN
A0A060T2Z9_BLAAD	55.27%	731	0.0	ARAD1A12254p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12254g PE=4 SV=1
Q6C7M1_YARLI	50.63%	715	0.0	YALI0D26972p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D26972g PE=4 SV=1
A0A167D0C5_9ASCO	54.81%	540	0.0	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_573 PE=4 SV=1
CBP1_CANAL	27.86%	323	8e-16	Corticosteroid-binding protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CBP1 PE=1 SV=2
A0A1E3PNR5_9ASCO	26.64%	274	7e-15	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81687 PE=4 SV=1
FMS1_YEAST	23.51%	387	7e-10	Polyamine oxidase FMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FMS1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0226
Predicted cleavage: 12

Protein family membership

None predicted.

Domains and repeats

Domain
544 - 645
Homeobox domain-like (IPR009057)
SWIRM domain (IPR007526)
647 - 1,061
FAD/NAD(P)-binding domain (IPR023753)
1,150 - 1,223
FAD/NAD(P)-binding domain (IPR023753)
Domain
552 - 644
Winged helix-turn-helix DNA-binding domain (IPR011991)
668 - 1,214
Amine oxidase (IPR002937)
1,382 - 1,470
High mobility group box domain (IPR009071)

1 200 400 600 800 1000 1200 1400 1571

Detailed signature matches

IPR009057

Homeobox domain-like
1. SSF46689 (Homeodoma...)
  
  546 - 642
  
  SUPERFAMILY
  SSF46689 (Homeodomain-like)
IPR007526

SWIRM domain
1. PF04433 (SWIRM)
  
  562 - 636
  
  Pfam
  PF04433 (SWIRM)
2. PS50934 (SWIRM)
  
  544 - 645
  
  PROSITE profiles
  PS50934 (SWIRM)
IPR011991

Winged helix-turn-helix DNA-binding domain
1. G3DSA:1.10.10.10
  
  552 - 644
  
  GENE3D
  G3DSA:1.10.10.10 (G3DSA:1.10.10.10)
IPR023753

FAD/NAD(P)-binding domain
1. G3DSA:3.50.50.60
  
  1,150 - 1,223
  
  GENE3D
  G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
  
  647 - 986
  
  GENE3D
  G3DSA:3.50.50.60 (G3DSA:3.50.50.60)
2. SSF51905 (FAD/NAD(P...)
  
  657 - 1,061
  
  SUPERFAMILY
  SSF51905 (FAD/NAD(P)-binding domain)
  
  1,173 - 1,217
  
  SUPERFAMILY
  SSF51905 (FAD/NAD(P)-binding domain)
IPR002937

Amine oxidase
1. PF01593 (Amino_oxidase)
  
  668 - 1,214
  
  Pfam
  PF01593 (Amino_oxidase)
IPR009071

High mobility group box domain
1. G3DSA:1.10.30.10
  
  1,391 - 1,462
  
  GENE3D
  G3DSA:1.10.30.10 (G3DSA:1.10.30.10)
2. PS50118 (HMG_BOX_2)
  
  1,389 - 1,469
  
  PROSITE profiles
  PS50118 (HMG_BOX_2)
3. PF09011 (HMG_box_2)
  
  1,388 - 1,467
  
  Pfam
  PF09011 (HMG_box_2)
4. SSF47095 (HMG-box)
  
  1,382 - 1,470
  
  SUPERFAMILY
  SSF47095 (HMG-box)

no IPR

Unintegrated signatures

Coil

252 - 272

COILS
Coil (Coil)

342 - 382

COILS
Coil (Coil)

1,495 - 1,525

COILS
Coil (Coil)

1,344 - 1,378

COILS
Coil (Coil)
G3DSA:3.90.66...

987 - 1,149

GENE3D
G3DSA:3.90.660.10 (G3DSA:3.90.660.10)
SSF54373 (FAD-linke...)

1,041 - 1,163

SUPERFAMILY
SSF54373 (FAD-linked reductases, C-terminal domain)
cd01390 (HMGB-UBF_H...)

1,383 - 1,459

CDD
cd01390 (HMGB-UBF_HMG-box)
mobidb-lite (disord...)

101 - 183

MobiDB Lite
mobidb-lite (disorder_prediction)

441 - 484

MobiDB Lite
mobidb-lite (disorder_prediction)

200 - 342

MobiDB Lite
mobidb-lite (disorder_prediction)

1,300 - 1,353

MobiDB Lite
mobidb-lite (disorder_prediction)

1,479 - 1,571

MobiDB Lite
mobidb-lite (disorder_prediction)

358 - 408

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

DNA binding site c...

1,384R

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,386M

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,394N

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,396F

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,397L

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,400Q

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,401K

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,404W

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,408R

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,433A

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,436G

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,439W

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

1,458K

DNA binding site
1,384R, 1,386M, 1,394N, 1,396F, 1,397L, 1,400Q, 1,401K, 1,404W, 1,408R, 1,433A, 1,436G, 1,439W, 1,458K
CDD
cd01390 (HMGB-UBF_HMG-box)

Protein sequence

>MCA_02636_1
MNNHSSNNRTYSVSDSYDDSTIIPSDFNSTNLSKSITNFDIGSGNSADMQITLDMPVSADSMGSNVDSQTSFDLSDLNFS
SSQSMSTTADSMNKMFLKDSSTSSLNNNINQSFQNHSSNSLTPSMNQNLFMSSQSQQQRGLSSNAKNNNENSLNNKKMAN
NINNNHNNLKGQTRKSIDESKKMSDSNSIMWSLYNNTLGSNSGSQQNDHTESLFGMDNSSSPFFSLSGESPQQQVTSPQQ
NNDHQTTQIQLISQLQSQRNQHQQQHNSLIKNSSKNQTPSLNYSSQNSPTNNASNDYGNNRNSPLSASLSPNQQQQQQQQ
QQQQQPQQQQHQQHQNQQSNNYQNHTQQLSNLLLQHQRQSNQQKLQQLKQQQQQQIEKNERDHQLMSKSQSVQHSQYQSQ
SHQKPQLNKRSNMQINLSQMNQSYNDIYNTPINRNIYKPVRGPSVNSNNDTHNHSSNILNGNNGHGSSSSSAVGTKNGNT
PEYPAATNVNHIISPQPLISPSINDTVAHHSFFSPPVAPHEAELMIIRQKYKAKSSIPQDVSIANYAQQCIYAAISSRLP
PFSLHIDEYNLLRSYIPQVHVTTYLNIRNGILRLWLSNPKVNVTRSEAAGCVKDDRFFNLAEVAYDWLVRGGYINFGCFE
YPSLDFYNPIPEDSRKPRKTIVIIGAGIAGLSCARQLDNLFQRKARHFAEYQGTPRVVVLEGKRRIGGRIYSAHLKSDRS
HAVDMGAQFIPGFGNGNPLAVVCRRQLGLPVTKVSPRTEIYDSLKKAKVSPELERRSTLLFNHLLERIGQFKSTISPPAT
ADGEEVLLRLCKDPPVEEYPGNLTLAKAEDMDRRKDKRHRKFDNDKQHEDYSYKENLGKIEAQFLKEIGITLKPGVADDA
VIHLIPEPQGDMYPSLGISMDAFLRQLQDISNITPEELRILNWHYANLEYQHGACLDHLSLNNWKHEGQNFTGQHSIVKN
GFMNLARGLYLFPENLDVRFKANVKFVEYSKDKVELYMENGERIKADKAVVTVPLGVLKDRTIQFIPDLPQWKQDSIERL
GFGVINKVCLVYKRPFWDENKDIIAICQPNEGNDPNDQDNYKNTRGRFYQFWNVSKAVGKPCLIGIVTGEAAVELSNETD
DMIVETAQSCIETVYSDVRDATLIESIVTRWQVDPFTRGSYSYVGLEATPADYDLLSKPVCDSLFFAGEATCRAYPATVH
GAYISGLRAASEILESLIGEIKIPQPLVPSKDYQANKRMIQQNIAGAVSSHVTPTSSMVHTPSNQPIPVDPVASYASTLA
VAAAAAAAAAASNINSNGHYQEYDNGNNNGDKKNDNNSKYHNNNGNSNNDNSNTDSDASYSGIKRKNQVEESEYEIKLRK
LKEERQMSENEAMRQEMIKQLGKRPMKPERSGANPFLIFQKDFWEKCRKQCDDEKQKSSGDVHARAARNEVRAALGKMWR
ELPEAEKIPYLQQTKEIKESNTRKTEEYRELVRRYDTEADDFKKKWKEEHPSKPSEEELRLMKLIQEEKKQLQQQQQQQQ
QQHNNDSGSYSKGKMNSPTMNNNSNLGSNGNSNGPNTKSSSPYKKTRYNNI

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0003677 DNA binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity

Cellular Component