Protein

MIA_02861_1

Length
297 amino acids

Browser: contig03:1945932-1946826-

Protein function

EGGNOG:0PGMETMP1thymidylate synthase
SGD closest match:S000005600CDC21Thymidylate synthase
CGD closest match:CAL0000189182TMP1Thymidylate synthase

Protein alignments

%idAln lengthE-value
MCA_01861_186.869%2970.0MCA_01861_1
A0A0J9XGE2_GEOCN78.983%2956.04e-174Similar to Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides OS=Geotrichum candidum GN=BN980_GECA15s00582g PE=3 SV=1
Q6CCB3_YARLI78.694%2912.89e-172YALI0C10901p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C10901g PE=3 SV=1
A0A167C2Z0_9ASCO77.055%2922.70e-165Thymidylate synthase OS=Sugiyamaella lignohabitans GN=CDC21 PE=3 SV=1
A0A060T624_BLAAD75.676%2964.90e-164ARAD1C16808p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C16808g PE=3 SV=1
A0A1E4TH09_9ASCO75.510%2942.17e-164Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2755 PE=3 SV=1
UniRef50_I1BT3973.913%2992.32e-159Thymidylate synthase n=8 Tax=Fungi TaxID=4751 RepID=I1BT39_RHIO9
A0A1E3PD51_9ASCO73.898%2951.78e-157Thymidylate synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53578 PE=3 SV=1
TYSY_YEAST68.792%2981.01e-148Thymidylate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC21 PE=1 SV=1
TYSY_CANAL66.454%3134.41e-147Thymidylate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TMP1 PE=3 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3729

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 297

Detailed signature matches

  1. Family IPR000398
    Thymidylate synthase
    1. PR00108 (THYMDSNTHASE)
    2. TIGR03284
    3. MF_00008 (Thymidy_s...)
  2. Domain IPR023451
    Thymidylate synthase/dCMP hydroxymethylase domain
    1. cd00351 (TS_Pyrimid...)
    2. SSF55831 (Thymidyla...)
    3. PF00303 (Thymidylat...)
    4. G3DSA:3.30.57...
  3. SITE IPR020940
    Thymidylate synthase, active site
    1. PS00091 (THYMIDYLAT...)

Residue annotation

  1. dimerization inter...
  2. active site cd00351

Protein sequence

>MIA_02861_1
MSISREEQGYLDLCREIIENGENRSDRTGTGTRSIFAPPQLRFSLSDDTLPLLTTKRVFYRGVLEELLWFVQGCTDSKQL
ENKNVHIWDGNGSREFLDSRGLTHRREGDLGPVYGFQWRHFGAPYKTCDDDYSGQGVDQLAQVIHTIKTNPYDRRIILSA
WNPADIPLMALPPCHMFAQFYVHNPNTPQAKLSCILYQRSCDMGLGVPFNIASYALLTKMIAHVCNIEAGELIHTMGDAH
VYLDHVDALKVQIARTPGEFPTLKFAREVKDIDDFKYEDFILENYKPQSKIEMSMSV

GO term prediction

Biological Process

GO:0006231 dTMP biosynthetic process

Molecular Function

GO:0004799 thymidylate synthase activity

Cellular Component

None predicted.