Protein

MCA_01861_1

Length
297 amino acids

Gene name: TMP1

Description: Thymidylate synthase

Browser: contigA:5714259-5715153-

RNA-seq: read pairs 540, FPKM 22.4, percentile rank 44.4% (100% = highest expression)

Protein function

Annotation:TMP1Thymidylate synthase
KEGG:K00560thyA thymidylate synthase [EC:2.1.1.45]
EGGNOG:0PGMETMP1thymidylate synthase
SGD closest match:S000005600CDC21Thymidylate synthase
CGD closest match:CAL0000189182TMP1Thymidylate synthase

Protein alignments

%idAln lengthE-value
MIA_02861_186.87%2970.0MIA_02861_1
A0A0J9XGE2_GEOCN79.32%2950.0Similar to Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides OS=Geotrichum candidum GN=BN980_GECA15s00582g PE=3 SV=1
Q6CCB3_YARLI77.66%2918e-177YALI0C10901p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C10901g PE=3 SV=1
UniRef50_I1BT3974.25%2993e-167Thymidylate synthase n=8 Tax=Fungi TaxID=4751 RepID=I1BT39_RHIO9
A0A1E4TH09_9ASCO74.83%2946e-168Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2755 PE=3 SV=1
A0A1E3PD51_9ASCO74.24%2957e-167Thymidylate synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53578 PE=3 SV=1
A0A060T624_BLAAD73.99%2966e-167ARAD1C16808p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C16808g PE=3 SV=1
A0A167C2Z0_9ASCO74.49%2941e-166Thymidylate synthase OS=Sugiyamaella lignohabitans GN=CDC21 PE=3 SV=1
TYSY_YEAST68.79%2981e-156Thymidylate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC21 PE=1 SV=1
TYSY_CANAL65.18%3132e-150Thymidylate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TMP1 PE=3 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2138

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 297

Detailed signature matches

  1. Family IPR000398
    Thymidylate synthase
    1. TIGR03284
    2. PR00108 (THYMDSNTHASE)
    3. MF_00008 (Thymidy_s...)
  2. Domain IPR023451
    Thymidylate synthase/dCMP hydroxymethylase domain
    1. cd00351 (TS_Pyrimid...)
    2. SSF55831 (Thymidyla...)
    3. PF00303 (Thymidylat...)
    4. G3DSA:3.30.57...
  3. SITE IPR020940
    Thymidylate synthase, active site
    1. PS00091 (THYMIDYLAT...)

Residue annotation

  1. dimerization inter...
  2. active site cd00351

Protein sequence

>MCA_01861_1
MSISREEQGYLDLCEEIIKNGERREDRTGTGTLSIFGPPQLRFSLENDILPLLTTKRVFYRGVLEELLWFVAGCTDSKKL
TEKNIHIWDGNGSREFLDSRGLTDRREGDLGPVYGFQWRHFGAKYKTCDDDYSNQGVDQLAQVINSIKTNPYDRRIILSA
WNPADIPIMALPPCHMFAQFYVSNPGTENAKLSCLLYQRSCDMGLGVPFNIASYALLTRMIAHVCKIKAGELIHTMGDAH
IYLDHVDAIKTQITRTPTEFPTLKFSREIDDIDDFKYEDFILEGYKPQSKIDMKMSV

GO term prediction

Biological Process

GO:0006231 dTMP biosynthetic process

Molecular Function

GO:0004799 thymidylate synthase activity

Cellular Component

None predicted.