Protein

MIA_02826_1

Length
427 amino acids

Browser: contig03:1863864-1865148-

Protein function

EGGNOG:0PIXIPGUG_03957protease
SGD closest match:S000004111YPS3Aspartic proteinase yapsin-3
CGD closest match:CAL0000190503SAP8Candidapepsin-8

Protein alignments

%idAln lengthE-value
A0A167FDB7_9ASCO39.535%3441.37e-54Yps3p OS=Sugiyamaella lignohabitans GN=YPS3 PE=3 SV=1
A0A060TAG1_BLAAD36.975%3572.68e-44ARAD1C45606p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C45606g PE=3 SV=1
UniRef50_A0A060TAG136.975%3576.61e-41ARAD1C45606p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060TAG1_BLAAD
Q6CDX2_YARLI34.111%3433.43e-37YALI0B20526p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B20526g PE=3 SV=1
M1XFD0_GEOCN34.974%3865.77e-35Aspartic protease OS=Geotrichum candidum GN=YSP3 PE=3 SV=1
MCA_06344_133.503%3947.00e-34MCA_06344_1
CARP8_CANAL35.942%3456.10e-34Candidapepsin-8 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SAP8 PE=1 SV=1
A0A1E3PJQ9_9ASCO31.957%4601.07e-31Acid protease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46336 PE=3 SV=1
YPS3_YEAST30.612%3923.95e-31Aspartic proteinase yapsin-3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPS3 PE=1 SV=1
A0A1E4TI13_9ASCO28.297%3641.12e-19Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_123212 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1982
Predicted cleavage: 33

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 427

Detailed signature matches

  1. Family IPR001461
    Aspartic peptidase A1 family
    1. PR00792 (PEPSIN)
  2. Domain IPR021109
    Aspartic peptidase domain
    1. G3DSA:2.40.70.10
    2. SSF50630 (Acid prot...)
  3. Domain IPR033121
    Peptidase family A1 domain
    1. PS51767 (PEPTIDASE_A1)
    2. PF00026 (Asp)
  4. Domain IPR033876
    Secreted aspartic endopeptidase
    1. cd05474 (SAP_like)
  5. SITE IPR001969
    Aspartic peptidase, active site
    1. PS00141 (ASP_PROTEASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SignalP-noTM

Residue annotation

  1. inhibitor binding ...
  2. catalytic residue ...
  3. catalytic motif cd...
  4. Active site flap c...

Protein sequence

>MIA_02826_1
MKLLPGVAAAVFFDVALGAPAHRQISINGRNNLPGMLSLDVTRRETPVSISTLKAVMLAQINADIGNRSDSDDSLFTVDL
MNQITHYSVNIGIGTNNKQYPLLIDTGSSDFWVSNSSDIVEIPYDYASDKSKILTTKPFHIDYVKGSMDGFWAKNTMYFG
SRIDDVDYAIVHKGVDSPKIRQSSGILGTSYSYRENKNLPELLTYQGLINKNAYSLSLANFNGSNGNLLFGGLDHSKYTG
DLVTVPRADFENSRLKTLSAKLTSLDIDGKTVAINGDKGIVAPLDTGTTLTYLPSDIYQQLASAFGVNSVNTLVYGAPCF
DVSQYGDKEVTFNFSGAKIKVKGSDLALDFKDFTGVDQGNMKIFGIWSNAYTRGYNILGDTFLRSAYVVYDLDGNTISLA
QANKNPGAPDIEVIYDEIPGAINFSDL

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

None predicted.