Protein

MCA_06344_1

Length
564 amino acids

Gene name: YPS3C

Description: aspartic protease

Browser: contigD:3914361-3916056+

RNA-seq: read pairs 2056, FPKM 45.0, percentile rank 63.0% (100% = highest expression)

Protein function

Annotation:YPS3Caspartic protease
EGGNOG:0PIXIPGUG_01925protease
SGD closest match:S000004111YPS3Aspartic proteinase yapsin-3
CGD closest match:CAL0000196689SAP2Candidapepsin-2

Protein alignments

%idAln lengthE-value
MIA_04462_155.96%4452e-173MIA_04462_1
M1XFD0_GEOCN53.35%4483e-159Aspartic protease OS=Geotrichum candidum GN=YSP3 PE=3 SV=1
UniRef50_M1XFD053.35%4486e-156Aspartic protease n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=M1XFD0_GEOCN
A0A167DZP5_9ASCO40.78%4348e-96Yps1p OS=Sugiyamaella lignohabitans GN=YPS1 PE=3 SV=1
A0A1E3PJQ9_9ASCO43.54%3955e-94Acid protease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46336 PE=3 SV=1
A0A060TDF2_BLAAD39.91%4263e-92ARAD1D06006p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D06006g PE=3 SV=1
YPS3_YEAST41.23%4051e-87Aspartic proteinase yapsin-3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPS3 PE=1 SV=1
Q6C6E4_YARLI40.39%4117e-86YALI0E10175p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E10175g PE=3 SV=1
CARP2_CANAL35.20%3753e-55Candidapepsin-2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SAP2 PE=1 SV=1
A0A1E4TI13_9ASCO31.61%3671e-34Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_123212 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0207

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 564

Detailed signature matches

  1. Family IPR001461
    Aspartic peptidase A1 family
    1. PR00792 (PEPSIN)
  2. Domain IPR021109
    Aspartic peptidase domain
    1. G3DSA:2.40.70.10
    2. SSF50630 (Acid prot...)
  3. Domain IPR033121
    Peptidase family A1 domain
    1. PS51767 (PEPTIDASE_A1)
    2. PF00026 (Asp)
  4. Domain IPR033876
    Secreted aspartic endopeptidase
    1. cd05474 (SAP_like)
  5. SITE IPR001969
    Aspartic peptidase, active site
    1. PS00141 (ASP_PROTEASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SignalP-noTM
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)
  10. mobidb-lite (disord...)

Residue annotation

  1. inhibitor binding ...
  2. catalytic residue ...
  3. catalytic motif cd...
  4. Active site flap c...

Protein sequence

>MCA_06344_1
MYSQLFIATALSLFLPSFADAKFLPQIEIPSFLNPHYNPNEDSNSFKHDVKLAPSGPGSKFTNNAVQIEFKIRRSDENIN
PRRRGLLPRRKPHYRGQIDPRDEVFEVPLLNQFTYYNIEIELGTPPQKFDIVIDTGSSDLWVIGKDNPYCSTNPSQLSSG
AYFDCRQSGIFDQEASSTYHRNNSLFMIKYGDGTVAEGDWGTDTLRIQDVVIENMSFGLGSLTNSTIGVFGVGYPENEAT
LSIKKNPYMYENLPVKLVNQGTINTPAYSLWLNDINAKSGNILFGGVDHAKYYGKLEVVPILPSGRFRKPSAFFVALDGV
TLSSGNYEAQVLNNGPVEALLDSGTSLTHLPRSIAEELLINQFEAQYSQTLGYFVQRCDLDGTLSYNFSGAIIDVPFANF
LFPIMGRSGNAVSDEGDPLCAIGIMPFDNQFALLGDTFLRNAYVVYDMKNNELGLAQAKINATDSDIEAIKSTIPSAIPA
PLYSATSRLSLLSSVSFNNRPRPTANNDGGEDGILATGSAVKPTSTDKGNAANTLPVMKTQSYIAICALMISVFISSSLL
LLII

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

None predicted.