Protein

MIA_02822_1

Length
412 amino acids

Browser: contig03:1851760-1853102-

Protein function

EGGNOG:0PIA2OGG1N-glycosylase DNA lyase
SGD closest match:S000004525OGG1N-glycosylase/DNA lyase
CGD closest match:CAL0000183658OGG18-oxoguanine glycosylase

Protein alignments

%idAln lengthE-value
MCA_03816_158.333%3604.07e-145MCA_03816_1
A0A0J9XC12_GEOCN52.688%3723.35e-134Similar to Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA OS=Geotrichum candidum GN=BN980_GECA08s03794g PE=4 SV=1
A0A060SYN6_BLAAD50.893%3361.03e-116ARAD1C02552p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C02552g PE=4 SV=1
UniRef50_B9WJV049.322%3699.24e-114Mitochondrial N-glycosylase/DNA lyase [includes: 8-oxoguanine DNA glycosylase DNA-(Apurinic or apyrimidinic site) lyase], putative n=13 Tax=Debaryomycetaceae TaxID=766764 RepID=B9WJV0_CANDC
A0A1D8PRH2_CANAL51.453%3448.84e-1178-oxoguanine glycosylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=OGG1 PE=4 SV=1
A0A1E3PEI0_9ASCO44.584%3971.35e-109DNA glycosylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53375 PE=4 SV=1
A0A167CV09_9ASCO49.128%3441.14e-1088-oxoguanine glycosylase OGG1 OS=Sugiyamaella lignohabitans GN=OGG1 PE=4 SV=1
A0A1E4TDV5_9ASCO46.883%3691.78e-107Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_98237 PE=4 SV=1
Q6CEU4_YARLI42.000%3504.33e-93YALI0B12870p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12870g PE=4 SV=1
OGG1_YEAST37.430%3583.41e-65N-glycosylase/DNA lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OGG1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0135

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 412

Detailed signature matches

  1. Domain IPR012904
    8-oxoguanine DNA glycosylase, N-terminal
    1. PF07934 (OGG_N)
  2. Domain IPR023170
    Helix-turn-helix, base-excision DNA repair, C-terminal
    1. G3DSA:1.10.16...
  3. Domain IPR011257
    DNA glycosylase
    1. SSF48150 (DNA-glyco...)
  4. Domain IPR003265
    HhH-GPD domain
    1. SM00478 (endo3end)
    2. PF00730 (HhH-GPD)
    3. cd00056 (ENDO3c)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.34...
  3. G3DSA:3.30.31...
  4. SSF55945 (TATA-box ...)

Residue annotation

  1. minor groove readi...
  2. helix-hairpin-heli...
  3. substrate binding ...
  4. active site cd00056

Protein sequence

>MIA_02822_1
MAALEWTKIALDPKELSLSKVLRCGQSFRWRNIDGIWSIGIKGRILFLKQDDSHLYYSSLNPPGLQPPSTGDLVNDYFNL
KVSVANLYKQWSSKDPHFLKMTTQIKDEIPMLTSSAPTSLSGIRVLRQDPWECLCCFICSSNNNIKRISQMVENLCRHFG
DHLGTHAGIEYYDFPTPESLAPKNVEQKLRDLGFGYRAKYIQQTAEKLAKTDSSTLLSPLGEDSAQPNDPLSGTEYLRAL
RQAPYKRAHAALLQFTGVGPKVADCVCLMSLDKHDCIPVDTHVWQIAKRDYSFKAKKANANNKAASLTKAEYEEIGVFFK
DLWGEFAGWAHSVLFTADLKDLNNGINGVEDATASKSAKRKRPKTEDKVQKTKLIKIEKIIDDDPAGKPNVLSTREQRLH
NRRKNLYIDLNP

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair

Molecular Function

GO:0003684 damaged DNA binding
GO:0003824 catalytic activity
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity

Cellular Component

None predicted.