Protein

MCA_03816_1

Length
373 amino acids

Gene name: OGG1

Description: N-glycosylase/DNA lyase

Browser: contigC:1164861-1166119-

RNA-seq: read pairs 294, FPKM 9.7, percentile rank 25.5% (100% = highest expression)

Protein function

Annotation:OGG1N-glycosylase/DNA lyase
KEGG:K03660OGG1 N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
EGGNOG:0PIA2OGG1N-glycosylase DNA lyase
SGD closest match:S000004525OGG1N-glycosylase/DNA lyase
CGD closest match:CAL0000183658OGG18-oxoguanine glycosylase

Protein alignments

%idAln lengthE-value
A0A0J9XC12_GEOCN63.78%3121e-142Similar to Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA OS=Geotrichum candidum GN=BN980_GECA08s03794g PE=4 SV=1
MIA_02822_160.06%3434e-141MIA_02822_1
UniRef50_W1QDM057.65%3075e-119N-glycosylase/DNA lyase n=3 Tax=Saccharomycetales TaxID=4892 RepID=W1QDM0_OGAPD
A0A1D8PRH2_CANAL53.09%3249e-1188-oxoguanine glycosylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=OGG1 PE=4 SV=1
A0A060SYN6_BLAAD55.81%3018e-117ARAD1C02552p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C02552g PE=4 SV=1
A0A167CV09_9ASCO55.45%3121e-1168-oxoguanine glycosylase OGG1 OS=Sugiyamaella lignohabitans GN=OGG1 PE=4 SV=1
A0A1E3PEI0_9ASCO51.86%3492e-115DNA glycosylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53375 PE=4 SV=1
A0A1E4TDV5_9ASCO53.67%3133e-112Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_98237 PE=4 SV=1
Q6CEU4_YARLI47.59%3112e-95YALI0B12870p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12870g PE=4 SV=1
OGG1_YEAST39.94%3288e-68N-glycosylase/DNA lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OGG1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0975

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 373

Detailed signature matches

  1. Domain IPR012904
    8-oxoguanine DNA glycosylase, N-terminal
    1. PF07934 (OGG_N)
  2. Domain IPR023170
    Helix-turn-helix, base-excision DNA repair, C-terminal
    1. G3DSA:1.10.16...
  3. Domain IPR011257
    DNA glycosylase
    1. SSF48150 (DNA-glyco...)
  4. Domain IPR003265
    HhH-GPD domain
    1. SM00478 (endo3end)
    2. PF00730 (HhH-GPD)
    3. cd00056 (ENDO3c)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.34...
  2. G3DSA:3.30.31...
  3. SSF55945 (TATA-box ...)

Residue annotation

  1. minor groove readi...
  2. helix-hairpin-heli...
  3. substrate binding ...
  4. active site cd00056

Protein sequence

>MCA_03816_1
MVSPSEWKHISVDIAELALSKVLRCGQSFRWKNVADVWSIGMKGRVLFLKQDAFNLYYQDMFNSGTHSISTPLIIKDYFN
LSVSVVDLYKQWSKCDPHFAKTIEANGESFKGIRMLRQDPWENLCSFICSSNNNIKRISQMVENLCTHFGTFLGEVDGIK
YYDFPTPQQLAKPETEEKLRALGFGYRAKYIQKTAMILCEKDDAMKYLETLRTASYKDAHNALLEFSGVGPKVADCVCLM
SLDKHDCVPVDTHVWQIATRDYKFRGKSKTASGNKSDYEAITLLFQNLWGKYAGWAHSVLFTADLKDLNNGVNKTDAKET
IVKKTIKRKKVVKSLSTETTPNAKIEVKIKTEETKVIDTGLRRSKRIKTTTGL

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair

Molecular Function

GO:0003684 damaged DNA binding
GO:0003824 catalytic activity
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity

Cellular Component

None predicted.