Protein

MIA_02817_1

Length
585 amino acids

Browser: contig03:1840019-1841777-

Protein function

EGGNOG:0PFI1HIS7Imidazole glycerol phosphate synthase subunit hisF
SGD closest match:S000000452HIS7Imidazole glycerol phosphate synthase hisHF
CGD closest match:CAL0000179206HIS7Imidazoleglycerol-phosphate synthase

Protein alignments

%idAln lengthE-value
MCA_02497_166.886%6070.0MCA_02497_1
A0A0J9X3D0_GEOCN67.687%5880.0Similar to Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (Glutamine amidotransferase:cyclase) OS=Geotrichum candidum GN=BN980_GECA02s03431g PE=3 SV=1
A0A167CTQ9_9ASCO60.611%5890.0Imidazoleglycerol-phosphate synthase OS=Sugiyamaella lignohabitans GN=HIS7 PE=3 SV=1
A0A060T2L1_BLAAD59.689%5780.0ARAD1A02332p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A02332g PE=3 SV=1
HIS5_YEAST61.775%5860.0Imidazole glycerol phosphate synthase hisHF OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS7 PE=1 SV=2
UniRef50_P3373461.775%5860.0Imidazole glycerol phosphate synthase hisHF n=238 Tax=cellular organisms TaxID=131567 RepID=HIS5_YEAST
A0A1E3PH19_9ASCO58.603%5870.0Glutamine amidotransferase:cyclase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83597 PE=3 SV=1
Q6CCR8_YARLI57.069%5800.0YALI0C07128p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C07128g PE=3 SV=1
A0A1E4TDM2_9ASCO54.374%5830.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1589 PE=3 SV=1
A0A1D8PRE9_CANAL50.159%6300.0Imidazoleglycerol-phosphate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HIS7 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0141

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 585

Detailed signature matches

  1. Family IPR014640
    Imidazole glycerol phosphate synthase HisHF
    1. PIRSF036936 (IGPS_H...)
  2. Family IPR006062
    Histidine biosynthesis
    1. PF00977 (His_biosynth)
  3. Family IPR004651
    Histidine biosynthesis, HisF
    1. TIGR00735
    2. cd04731 (HisF)
  4. Domain IPR029062
    Class I glutamine amidotransferase-like
    1. G3DSA:3.40.50...
    2. SSF52317 (Class I g...)
  5. Domain IPR017926
    Glutamine amidotransferase
    1. PF00117 (GATase)
    2. PS51273 (GATASE_TYPE_1)
  6. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  7. Domain IPR011060
    Ribulose-phosphate binding barrel
    1. SSF51366 (Ribulose-...)

Residue annotation

  1. substrate binding ...
  2. glutamase interact...

Protein sequence

>MIA_02817_1
MSKTAYVIDVESGNLQSLNNVIELLGWTPVLIKTPEDLVSKLANQEDPRLFLPGVGNFGHFVHELNVRGFSQPIRDYIES
GRRLMGICVGLQTVFADSEEANNEDTNGSKAQGLGIVGRSLLRFSDKDKSVPQIGWNTIKYANAEDKSIGLYGLDPSSRY
YFVNSFAAILTPEETQLAQAGRINDVAGFKDNSLGPFEVALTTYGSQTFVSAIAFKNVFLTQFHPEKCGKAGVRVLEAFL
SGTKHTPLSERAKAAKPPGREVNGLTARIVACLDVRTNDAGDLVVTKGDQYDVRERQVDGAGNPVRNLGKPVELAQMYYE
QGADEVTFLNITSFRNSPLRDLPMLTVLKEASKTVFVPLTVGGGIRDTLDPETNKLVPALEVAALYFRSGADKVSIGSDS
VSAAEAYYARGGKGDGTSPIETISKAYGAQAVVISVDPRKVYVASPEAAPANTHVIKTAYPGPNGEEYVWYQCTIKGGRE
SRPLGVYELVRACEALGAGEILLNSIDKDGSNSGYDLELVRLAKSAVSIPVIASSGAGKPEHFVEVFEKTNVDAALGAGM
FHRKEYTVDQVKEVLEENGIAVRRD

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process
GO:0008152 metabolic process

Molecular Function

GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0003824 catalytic activity
GO:0016763 transferase activity, transferring pentosyl groups
GO:0016833 oxo-acid-lyase activity

Cellular Component

GO:0005737 cytoplasm