Protein

MCA_02497_1

Length
605 amino acids

Gene name: HIS7

Description: Imidazole glycerol phosphate synthase hisHF

Browser: contigB:1478946-1480764-

RNA-seq: read pairs 2179, FPKM 44.4, percentile rank 62.7% (100% = highest expression)

Protein function

Annotation:HIS7Imidazole glycerol phosphate synthase hisHF
KEGG:K01663HIS7 glutamine amidotransferase / cyclase [EC:2.4.2.- 4.1.3.-]
EGGNOG:0PFI1HIS7Imidazole glycerol phosphate synthase subunit hisF
SGD closest match:S000000452HIS7Imidazole glycerol phosphate synthase hisHF
CGD closest match:CAL0000179206HIS7Imidazoleglycerol-phosphate synthase

Protein alignments

%idAln lengthE-value
MIA_02817_166.89%6070.0MIA_02817_1
A0A0J9X3D0_GEOCN62.21%6060.0Similar to Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (Glutamine amidotransferase:cyclase) OS=Geotrichum candidum GN=BN980_GECA02s03431g PE=3 SV=1
A0A167CTQ9_9ASCO56.57%6010.0Imidazoleglycerol-phosphate synthase OS=Sugiyamaella lignohabitans GN=HIS7 PE=3 SV=1
A0A060T2L1_BLAAD56.78%5970.0ARAD1A02332p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A02332g PE=3 SV=1
UniRef50_A0A099P82856.07%6010.0Uncharacterized protein n=12 Tax=Fungi TaxID=4751 RepID=A0A099P828_PICKU
HIS5_YEAST56.09%6080.0Imidazole glycerol phosphate synthase hisHF OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS7 PE=1 SV=2
A0A1E3PH19_9ASCO55.89%6030.0Glutamine amidotransferase:cyclase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83597 PE=3 SV=1
Q6CCR8_YARLI54.61%5970.0YALI0C07128p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C07128g PE=3 SV=1
A0A1D8PRE9_CANAL52.52%6340.0Imidazoleglycerol-phosphate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HIS7 PE=3 SV=1
A0A1E4TDM2_9ASCO51.25%5990.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1589 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0302

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 605

Detailed signature matches

  1. Family IPR014640
    Imidazole glycerol phosphate synthase HisHF
    1. PIRSF036936 (IGPS_H...)
  2. Family IPR010139
    Imidazole glycerol phosphate synthase, subunit H
    1. TIGR01855
  3. Family IPR006062
    Histidine biosynthesis
    1. PF00977 (His_biosynth)
  4. Family IPR004651
    Histidine biosynthesis, HisF
    1. TIGR00735
    2. cd04731 (HisF)
  5. Domain IPR029062
    Class I glutamine amidotransferase-like
    1. G3DSA:3.40.50...
    2. SSF52317 (Class I g...)
  6. Domain IPR017926
    Glutamine amidotransferase
    1. PF00117 (GATase)
    2. PS51273 (GATASE_TYPE_1)
  7. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  8. Domain IPR011060
    Ribulose-phosphate binding barrel
    1. SSF51366 (Ribulose-...)

Residue annotation

  1. substrate binding ...
  2. glutamase interact...

Protein sequence

>MCA_02497_1
MSSKTAYIIDVESGNLQSLQNAVEKLGWNAVLLKSADDFAKVLSEESSSSIRVFLPGVGNFGHFAKQLHKLGFSQLIKDF
ISNGGHLMGICVGLQFFFKESEESQKVDETVSQPELLSGLQVVNRKLYRFSDSEKSVPHIGWNSAKFVSSDRTSNGNSSE
RKGLYGIEDYGRYYFVNSYAVIITPDEQATIEQGKINTVNGFENSSKTVDVTLTTYGAETFISSIAFDNLFLTQFHPEKC
GNAGLKIIEAFLSGNKYTTQTIPAPKQKLKETNGLTARIVACLDVRTNDDGDLVVTKGDQYNVREVEKEIKESNSDGKKA
GNVRNLGKPVEMAHKYFSQGADEVTFLNITSFRNSPLKDLPMLEVLKRASQSVFVPLTVGGGIRDTLDPETGKLVPALDV
ATLYFRSGADKISIGSDAVSAAEQYYKNGCKGDGTSPIETISKAYGVQAVVVSVDPKRQYLKSREDAPENIHVIEVSPGN
EGPNGEKFAWYQCTIKGGRELRPLGAYELVVACEALGAGEILLNCIDKDGSNSGYDLDLVNLVKSAVKIPVIASSGAGNP
MHFLEVFEKTNVDAALGAGMFHRGEYTVNQVKDVLEEHGIAVRRD

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process
GO:0008152 metabolic process

Molecular Function

GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0003824 catalytic activity
GO:0016763 transferase activity, transferring pentosyl groups
GO:0016833 oxo-acid-lyase activity

Cellular Component

GO:0005737 cytoplasm