Protein
MIA_02784_1
Length
398 amino acids
Browser: contig03:1755342-1756604-
Protein function
| EGGNOG: | 0PHX8 | NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Has weak NAD-dependent protein deacetylase activity | |
|---|---|---|---|
| SGD closest match: | S000005429 | HST1 | NAD-dependent protein deacetylase HST1 |
| CGD closest match: | CAL0000195751 | CAALFM_C102740CA | NAD-dependent protein deacylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_01517_1 | 63.981% | 422 | 8.91e-169 | MCA_01517_1 |
| A0A0J9XCF8_GEOCN | 78.571% | 154 | 1.91e-79 | Similar to Saccharomyces cerevisiae YDL042C SIR2 Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan OS=Geotrichum candidum GN=BN980_GECA09s01176g PE=4 SV=1 |
| Q6C8C7_YARLI | 72.903% | 155 | 9.38e-79 | YALI0D20724p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D20724g PE=4 SV=1 |
| A0A1E3PRT3_9ASCO | 74.172% | 151 | 6.92e-74 | DHS-like NAD/FAD-binding domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_72569 PE=4 SV=1 |
| UniRef50_A0A0U5C8S3 | 60.656% | 183 | 7.55e-68 | Putative Silent information regulator protein Sir2p n=2 Tax=leotiomyceta TaxID=716546 RepID=A0A0U5C8S3_9EURO |
| A0A060T570_BLAAD | 72.368% | 152 | 1.94e-70 | NAD-dependent protein deacylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08184g PE=3 SV=1 |
| SIR5_CANAL | 58.750% | 160 | 5.10e-62 | NAD-dependent protein deacylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C102740CA PE=3 SV=1 |
| A0A167F7R7_9ASCO | 76.106% | 113 | 5.09e-54 | Ugo1p OS=Sugiyamaella lignohabitans GN=UGO1 PE=3 SV=1 |
| HST1_YEAST | 30.070% | 143 | 5.41e-11 | NAD-dependent protein deacetylase HST1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST1 PE=1 SV=1 |
| A0A1E4TME4_9ASCO | 26.897% | 145 | 1.11e-10 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19658 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.4696
Predicted cleavage: 38
Protein family membership
- Sirtuin family (IPR003000)
- Sirtuin, class III (IPR027546)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
398
Detailed signature matches
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MIA_02784_1 MSSDLASFQQHLQNSKRIIALVGAGLSASSGLPTFRGSGGLWRNYDAMDLATPDAFQNDPSLVWQFYSYRRHAALRAKPN KGHYALAELARRRPGQFLTLTQNVDGLSARAQHPPEELLCLHGDLFTVKCTSFMCSYKQEGVLDDPLTPALKVDDEEYAA DPNYKKLNHGAAGPANGASTEDALKKSLFGKGLTLEQQRDAGYSSSGLTTTDGLTTDGTDGYSSASSFFFPNGYNAPSRK KKTDPVEPAPADPHDEAHAKKKSRKKKFITKDIPLDLLPRCPSCKVGLLRPGVVWFGEALPFNVLQRADDFITADPPVDL ILVIGTSGSVWPAAGYVEQVAMRGGKVAVFNIDVDEESSIATDLIKNGGGWAFQGDAAEILPKALEPVIGTLRSHRKY
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding
Cellular Component
None predicted.