Protein
MCA_01517_1
Length
381 amino acids
Description: Sirtuin family protein
Browser: contigA:4698665-4699896-
RNA-seq: read pairs 1420, FPKM 45.9, percentile rank 63.4% (100% = highest expression)
Protein function
| Annotation: | Sirtuin family protein | ||
|---|---|---|---|
| EGGNOG: | 0PHX8 | NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Has weak NAD-dependent protein deacetylase activity | |
| CGD closest match: | CAL0000195751 | CAALFM_C102740CA | NAD-dependent protein deacylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9XCF8_GEOCN | 57.55% | 384 | 1e-125 | Similar to Saccharomyces cerevisiae YDL042C SIR2 Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan OS=Geotrichum candidum GN=BN980_GECA09s01176g PE=4 SV=1 |
| MIA_02784_1 | 86.62% | 157 | 5e-83 | MIA_02784_1 |
| UniRef50_A5DW75 | 43.24% | 414 | 5e-73 | NAD-dependent protein deacylase n=1 Tax=Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) TaxID=379508 RepID=A5DW75_LODEL |
| Q6C8C7_YARLI | 71.79% | 156 | 1e-67 | YALI0D20724p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D20724g PE=4 SV=1 |
| A0A1E3PRT3_9ASCO | 67.68% | 164 | 5e-61 | DHS-like NAD/FAD-binding domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_72569 PE=4 SV=1 |
| A0A060T570_BLAAD | 71.71% | 152 | 2e-58 | NAD-dependent protein deacylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08184g PE=3 SV=1 |
| A0A167F7R7_9ASCO | 76.11% | 113 | 7e-52 | Ugo1p OS=Sugiyamaella lignohabitans GN=UGO1 PE=3 SV=1 |
| SIR5_CANAL | 59.62% | 156 | 2e-50 | NAD-dependent protein deacylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C102740CA PE=3 SV=1 |
| A0A1E4TKK0_9ASCO | 34.12% | 85 | 5e-08 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_42871 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.6693
Predicted cleavage: 38
Protein family membership
- Sirtuin family (IPR003000)
- Sirtuin, class III (IPR027546)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
381
Detailed signature matches
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MCA_01517_1 MSNDLASFQQYLVRSKRIIALVGAGLSSSSGLPTFRGAGGLWNNYDAMSLATPDAFHNDPSLVWQFYSYRRHAALKAKPN KGHYALAELARRRPSTFLTLTQNVDGLSARANHPEESLLCLHGDLFTVKCTSFMCSYKQDRVFDDPLTPALKVTDDDELP STSDNLNSSDNESSTGFTTTDVDDSSYSSSSSFSIPNGYNFSTSSKKKKTDSGSGNKDSNSSKKAPKKKKVIKNIPLDSL PKCPSCKVGLLRPGVVWFGEALPFNVLKKADDFITDPNEPPVDLILVIGTSGTVWPAAGYVEQVVLRGGKVAVFNIDVES EESIATDLLKNGPNKGKKRKSDTNDQADNMPQGWAFKGDAAELLPIALEPIIGQLRPPRKY
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding
Cellular Component
None predicted.