Protein

MIA_02776_1

Length
328 amino acids

Browser: contig03:1732036-1733092-

Protein function

EGGNOG:0PIV9PGUG_03064ubiquitin carboxyl-terminal hydrolase
CGD closest match:CAL0000184421YUH2Ubiquitin carboxyl-terminal hydrolase

Protein alignments

%idAln lengthE-value
MCA_01420_154.318%3594.66e-108MCA_01420_1
A0A0J9X592_GEOCN54.192%3343.12e-100Ubiquitin carboxyl-terminal hydrolase OS=Geotrichum candidum GN=BN980_GECA02s03211g PE=3 SV=1
UniRef50_A0A0J9X59254.192%3346.38e-97Ubiquitin carboxyl-terminal hydrolase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X592_GEOCN
A0A060T833_BLAAD52.769%3072.13e-94Ubiquitin carboxyl-terminal hydrolase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C33198g PE=3 SV=1
Q6CEC7_YARLI46.483%3272.00e-92Ubiquitin carboxyl-terminal hydrolase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B16698g PE=3 SV=1
A0A1D8PNY8_CANAL43.252%3261.05e-76Ubiquitin carboxyl-terminal hydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=YUH2 PE=3 SV=1
A0A1E3PRI8_9ASCO41.600%3751.13e-72Ubiquitin carboxyl-terminal hydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44711 PE=3 SV=1
A0A1E4TK82_9ASCO39.344%3055.52e-62Ubiquitin carboxyl-terminal hydrolase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_82019 PE=3 SV=1
A0A161HME6_9ASCO28.440%2181.57e-07Ubiquitin carboxyl-terminal hydrolase OS=Sugiyamaella lignohabitans GN=YUH1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0958

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 328

Detailed signature matches

  1. Family IPR017390
    Ubiquitinyl hydrolase, UCH37 type
    1. PIRSF038120 (Uch)
  2. Domain IPR001578
    Peptidase C12, ubiquitin carboxyl-terminal hydrolase
    1. PF01088 (Peptidase_C12)
    2. G3DSA:3.40.53...
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF54001 (Cysteine ...)
  2. cd09617 (Peptidase_...)
  3. mobidb-lite (disord...)

Residue annotation

  1. cancer-causing mut...
  2. catalytic site cd0...

Protein sequence

>MIA_02776_1
MSELGWNTIESDAGVFTELIEKLGVTGLEFEELLSIDPDTLASVTPLYGVIFLFKYRRSEFEAMRRKTQAEGGAAKPLDG
TYATAAEDVFFAHQVIQNACATQAVLSLLLNLPDHTSGHEQVAKVLGSTLSEFREFVSAFDPELKGEAVSNSEQIRAAHN
SFSRPPAVLDDDKDNRPDRDEEDDGLYHFIAYTRVHDTLYELDGLHSHPISHGPCTDSQLPEALAEVLARRISRAPAGDL
RFNLLALTADPRPALRAVGDEAGLAREEAKRAAWRRENVLRRANYTGLVTALVRGITAQRISAGDDWNKTVLEPATKKSR
ELYNSRKQ

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

GO:0005622 intracellular