Protein

MIA_02763_1

Length
348 amino acids

Browser: contig03:1690920-1691967-

Protein function

EGGNOG:0PGPIPGUG_00703dihydroorotase
SGD closest match:S000004412URA4Dihydroorotase
CGD closest match:CAL0000193314URA4Dihydroorotase

Protein alignments

%idAln lengthE-value
A0A0J9X6H3_GEOCN73.088%3530.0Similar to Saccharomyces cerevisiae YLR420W URA4 Dihydroorotase OS=Geotrichum candidum GN=BN980_GECA03s01099g PE=4 SV=1
MCA_04394_173.938%3530.0MCA_04394_1
A0A060TBZ5_BLAAD71.137%3430.0ARAD1B12760p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B12760g PE=4 SV=1
A0A167DHK6_9ASCO72.674%3441.24e-180Dihydroorotase OS=Sugiyamaella lignohabitans GN=URA4 PE=4 SV=1
A0A1E3PCA1_9ASCO65.407%3443.90e-169Dihydroorotase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48278 PE=4 SV=1
Q6C0P7_YARLI64.348%3451.82e-166YALI0F22781p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F22781g PE=4 SV=1
A0A1E4TCE6_9ASCO64.035%3421.02e-163Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_139389 PE=4 SV=1
UniRef50_C8VUF655.714%3501.02e-133ORF [Source:UniProtKB/TrEMBLAcc:P79041] n=252 Tax=Fungi TaxID=4751 RepID=C8VUF6_EMENI
PYRC_YEAST52.646%3592.50e-134Dihydroorotase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA4 PE=1 SV=2
Q5A1L8_CANAL53.631%3583.66e-133Dihydroorotase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA4 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0168

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 348

Detailed signature matches

  1. Family IPR004721
    Dihydroorotase homodimeric type
    1. PIRSF001237 (Dihydr...)
    2. TIGR00856
    3. SFLDF00074 (dihydro...)
    4. cd01294 (DHOase)
  2. Domain IPR032466
    Metal-dependent hydrolase
    1. SSF51556 (Metallo-d...)
  3. Domain IPR006680
    Amidohydrolase-related
    1. PF04909 (Amidohydro_2)
  4. SITE IPR002195
    Dihydroorotase, conserved site
    1. PS00483 (DIHYDROORO...)
    2. PS00482 (DIHYDROORO...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.20.20...

Residue annotation

  1. active site cd01294
  2. SFLDF00074
  3. substrate binding ...
  4. dimer interface cd...

Protein sequence

>MIA_02763_1
MSTEQTRIPLGKPGDFHVHLRQGDLMKIVTPTITPGGVSIVYVMPNLVPPLIDVDAVLAYKAQLQELSPETTFLMSLYLR
PEITPEVIAQAAKAGITGVKCYPAGVTTNSAAGVSSYEPYYPTFKAMEEHNMVLNLHGECPSGDDITVLNAEHKFLPTLA
GLHSRFPKLRIILEHCTSKAAVDAVLACGPTVAATITAHHLFLTVDSWGGNALNFCKPVAKLPSDRTALIEAATSGNPKF
FFGSDSAPHPVSAKRKELGAAAGVFTQPYAIQYVAEIFDKAGKLDKLKGFVTDFGRDFYQAPEDKDVGKKSVTLVKAETV
VSESVGAEDMTVIPFLAGQSLKWAIEWE

GO term prediction

Biological Process

GO:0019856 pyrimidine nucleobase biosynthetic process

Molecular Function

GO:0004151 dihydroorotase activity
GO:0016787 hydrolase activity
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Cellular Component

None predicted.