Protein

MCA_04394_1

Length
355 amino acids

Gene name: URA4

Description: Dihydroorotase

Browser: contigC:2875953-2877021-

RNA-seq: read pairs 1743, FPKM 60.5, percentile rank 69.5% (100% = highest expression)

Protein function

Annotation:URA4Dihydroorotase
KEGG:K01465URA4 dihydroorotase [EC:3.5.2.3]
EGGNOG:0PGPIPGUG_00703dihydroorotase
SGD closest match:S000004412URA4Dihydroorotase
CGD closest match:CAL0000193314URA4Dihydroorotase

Protein alignments

%idAln lengthE-value
MIA_02763_173.94%3530.0MIA_02763_1
A0A0J9X6H3_GEOCN65.07%3552e-163Similar to Saccharomyces cerevisiae YLR420W URA4 Dihydroorotase OS=Geotrichum candidum GN=BN980_GECA03s01099g PE=4 SV=1
A0A060TBZ5_BLAAD67.05%3493e-162ARAD1B12760p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B12760g PE=4 SV=1
A0A167DHK6_9ASCO65.24%3514e-160Dihydroorotase OS=Sugiyamaella lignohabitans GN=URA4 PE=4 SV=1
Q6C0P7_YARLI60.74%3491e-150YALI0F22781p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F22781g PE=4 SV=1
A0A1E3PCA1_9ASCO60.86%3503e-150Dihydroorotase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48278 PE=4 SV=1
A0A1E4TCE6_9ASCO59.09%3523e-143Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_139389 PE=4 SV=1
PYRC_YEAST54.59%3702e-131Dihydroorotase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA4 PE=1 SV=2
UniRef50_P2005154.59%3705e-128Dihydroorotase n=95 Tax=Ascomycota TaxID=4890 RepID=PYRC_YEAST
Q5A1L8_CANAL53.33%3604e-121Dihydroorotase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA4 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0102

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 355

Detailed signature matches

  1. Family IPR004721
    Dihydroorotase homodimeric type
    1. PIRSF001237 (Dihydr...)
    2. TIGR00856
    3. SFLDF00074 (dihydro...)
  2. Domain IPR032466
    Metal-dependent hydrolase
    1. SSF51556 (Metallo-d...)
  3. Domain IPR006680
    Amidohydrolase-related
    1. PF04909 (Amidohydro_2)
  4. SITE IPR002195
    Dihydroorotase, conserved site
    1. PS00483 (DIHYDROORO...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.20.20...

Residue annotation

  1. SFLDF00074

Protein sequence

>MCA_04394_1
MAQERIELGRPGDFHVHLRQDKLMEIVTPTVEQGGVSIVYVMPNLVPPITSVDRVLEYKQQLQKISPNTTFLMSLYLRPE
ITPEVIHAAAEAGVSGVKCYPAGVTTNSAQGVTSYEPYYPVFEAMQEHDMVLNLHGECPSTHEHDGITVLNAESKFLPTL
VDLSTRFPKLRIILEHCTSQEAIETVKKCGPNVAATITAHHLFLTVDSWGGNALNFCKPVAKLPSDRDALVEAAISGNPK
FFFGSDSAPHFLQAKKKEAGAAAGVFTQPYAIPYVAQLFEKHGKLDRLKGFVTDFGRQFYKTPEENDVGDKTKKVVLVKK
PTVVADAIGGPDAKDDQIVIPFMAGKTLDWSVQWE

GO term prediction

Biological Process

GO:0019856 pyrimidine nucleobase biosynthetic process

Molecular Function

GO:0004151 dihydroorotase activity
GO:0016787 hydrolase activity
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Cellular Component

None predicted.