Protein

MIA_02736_1

Length
505 amino acids

Browser: contig03:1593434-1594952-

Protein function

EGGNOG:0PHX7PGUG_05616Pyruvate dehydrogenase kinase
SGD closest match:S000001304PKP1[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
CGD closest match:CAL0000180154PDK2Protein kinase

Protein alignments

%idAln lengthE-value
MCA_00813_175.775%5160.0MCA_00813_1
A0A0J9X2X3_GEOCN63.253%4980.0Similar to Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity OS=Geotrichum candidum GN=BN980_GECA01s06841g PE=4 SV=1
UniRef50_A0A0J9X2X363.253%4980.0Similar to Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2X3_GEOCN
Q6CB64_YARLI45.509%5019.29e-149YALI0C21582p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C21582g PE=4 SV=2
A0A1E4TEQ5_9ASCO45.129%5037.10e-144Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_104124 PE=4 SV=1
A0A167D8E5_9ASCO43.295%5221.82e-135Protein kinase PKP1 OS=Sugiyamaella lignohabitans GN=PKP1 PE=4 SV=1
A0A1E3PSG6_9ASCO42.770%4911.47e-134Pyruvate dehydrogenase kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_19956 PE=4 SV=1
A0A060T4Z7_BLAAD42.505%5279.84e-131ARAD1C07326p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C07326g PE=4 SV=1
A0A1D8PTU9_CANAL37.017%5431.72e-116Protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDK2 PE=4 SV=1
PDK1_YEAST26.695%2361.27e-20[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9348
Predicted cleavage: 20

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 505

Detailed signature matches

  1. Domain IPR018955
    Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    1. SSF69012 (alpha-ket...)
    2. G3DSA:1.20.14...
    3. PF10436 (BCDHK_Adom3)
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
    4. SM00387 (HKATPase_4)
  3. Domain IPR005467
    Histidine kinase domain
    1. PS50109 (HIS_KIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00075 (HATPase_c)
  2. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MIA_02736_1
MSSVVKPSTAQRISHYARFPPTALSLAQMAQFGQTPSTATVYRAAQFMADELPVRLAHRVRELENLPEGLGESPSIQRVL
GWYVKSFEDIVDMQQYAQERLPDKVRANLLQVSSESLSMPAKQFNENVQDDYIKPTLKTLKSPQDGSNPNDPENRHHNEA
HHKSFFGSLKDRLFSGFGGSPLTKFDGDQKWPPEVHEYLDAFKDCLTKVRKRHDAVVTTMAQGIKEYSEKHRLKQGSSAN
GSSPDHHRNNNHYMNYNYDFGNTNGEIVKRHGMIEPGFHEQRIQSFLDRFFMSRIGIRMLIGQQLALMEGRFAPDYVGII
CTNTGVKETIQHAVTLAEEICEDTYGLYEGPKVIIECDPDLRFMYIPAHLSHMIFETVKNSLRAVVEKYGVDVESKAYPP
VTIVVGDGSEDITIRISDKGGGIPRSVQQRVWMYNYTTVKEPPKIGPEFSEPMMGAPMAGFGYGLPITRLYARYFGGDVV
LQSIEGYGTDVYMHLNKLSTRELIF

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.