Protein

MCA_00813_1

Length
492 amino acids

Gene name: PKP1A

Description: [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial

Browser: contigA:2526780-2528259-

RNA-seq: read pairs 2546, FPKM 63.8, percentile rank 70.6% (100% = highest expression)

Protein function

Annotation:PKP1A[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
KEGG:K00898PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2]
EGGNOG:0PHX7PGUG_05616Pyruvate dehydrogenase kinase
SGD closest match:S000001304PKP1[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
CGD closest match:CAL0000180154PDK2Protein kinase

Protein alignments

%idAln lengthE-value
MIA_02736_176.18%5080.0MIA_02736_1
A0A0J9X2X3_GEOCN63.73%4880.0Similar to Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity OS=Geotrichum candidum GN=BN980_GECA01s06841g PE=4 SV=1
UniRef50_A0A0J9X2X363.73%4880.0Similar to Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2X3_GEOCN
Q6CB64_YARLI47.01%4853e-148YALI0C21582p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C21582g PE=4 SV=2
A0A1E4TEQ5_9ASCO47.17%4775e-146Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_104124 PE=4 SV=1
A0A1E3PSG6_9ASCO44.86%4772e-141Pyruvate dehydrogenase kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_19956 PE=4 SV=1
A0A167D8E5_9ASCO43.13%5172e-138Protein kinase PKP1 OS=Sugiyamaella lignohabitans GN=PKP1 PE=4 SV=1
A0A060T4Z7_BLAAD40.91%5282e-127ARAD1C07326p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C07326g PE=4 SV=1
A0A1D8PTU9_CANAL37.52%5413e-115Protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDK2 PE=4 SV=1
PDK1_YEAST28.07%2285e-22[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8809
Predicted cleavage: 26

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 492

Detailed signature matches

  1. Domain IPR018955
    Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    1. SSF69012 (alpha-ket...)
    2. G3DSA:1.20.14...
    3. PF10436 (BCDHK_Adom3)
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
    4. SM00387 (HKATPase_4)
  3. Domain IPR005467
    Histidine kinase domain
    1. PS50109 (HIS_KIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. cd00075 (HATPase_c)
  7. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MCA_00813_1
MSALAATAASVSKETAKKIAHYARFPPTALSLAQMAQFGQTPSTATVYRASQFMADELPVRLAHRVRELENLPDGLPEAP
SIKRVHGWYVKSFEDIVEMQQYAREHLSDQLRSDLLQVSSETLSSPAKKFNINVDKDYIKPTLTNGANVTSPPSPPETTQ
HKSFFGSLKDRFFGSSNPLQKFDGDQKWPKEVYDYLDKFSECLTKVRKRHDAVVTTIAQGIKEYAIQRKSSNSSKKSRIT
NSSSNGESTIEQEIIKRNGMIEPDHTEQRIQSFLDRFFMSRIGIRMLIGQQLALMEGKFAPDYVGIICTNTSVKQTIQHA
VTLASEICEDTYGLYEGPKVIIECDPDLRFMYIPAHLSHMIFELVKNSLRAVVEKYGIEVDSKEYPPVTIVVGDGSEDIT
IRISDKGGGIPRSVQQSVWMYNYTTVKEPPNIGPEFSQPMMGAPMAGFGYGLPITRLYARYFGGDVVLQSIEGYGTDVYM
HLNKLSTRELIF

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.