Protein

MIA_02718_1

Length
765 amino acids

Browser: contig03:1534449-1536747+

Protein function

EGGNOG:0PGIMPGUG_04303dna repair helicase
SGD closest match:S000000973RAD3DNA repair helicase RAD3
CGD closest match:CAL0000192893RAD3TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit

Protein alignments

%idAln lengthE-value
MCA_01687_189.831%7670.0MCA_01687_1
A0A0J9XJA5_GEOCN81.404%7690.0Similar to Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase OS=Geotrichum candidum GN=BN980_GECA23s00186g PE=4 SV=1
A0A1E3PJI6_9ASCO79.494%7510.0DNA repair helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50880 PE=4 SV=1
A0A161HM58_9ASCO82.055%7300.0TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 OS=Sugiyamaella lignohabitans GN=RAD3 PE=4 SV=1
A0A060TCL9_BLAAD77.749%7640.0ARAD1D37136p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37136g PE=4 SV=1
Q6C0Y5_YARLI75.654%7640.0YALI0F20746p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20746g PE=4 SV=1
A0A1D8PQH0_CANAL77.868%7410.0TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD3 PE=4 SV=1
UniRef50_A0A099P60676.590%7390.0Uncharacterized protein n=2 Tax=Pichia kudriavzevii TaxID=4909 RepID=A0A099P606_PICKU
RAD3_YEAST74.206%7560.0DNA repair helicase RAD3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD3 PE=1 SV=1
A0A1E4TMC0_9ASCO76.316%6080.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30908 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0171

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
  4. Domain
1 100 200 300 400 500 600 700 765

Detailed signature matches

  1. Family IPR013020
    DNA helicase (DNA repair), Rad3 type
    1. TIGR00604
  2. Family IPR001945
    RAD3/XPD family
    1. PR00852 (XRODRMPGMNTD)
  3. Domain IPR014013
    Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
    1. PS51193 (HELICASE_A...)
  4. Domain IPR006554
    Helicase-like, DEXD box c2 type
    1. SM00488 (deadxpd)
  5. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  6. Domain IPR010614
    DEAD2
    1. PF06733 (DEAD_2)
  7. Domain IPR010643
    Helical and beta-bridge domain
    1. PF06777 (HBB)
  8. Domain IPR006555
    ATP-dependent helicase, C-terminal
    1. PF13307 (Helicase_C_2)
    2. SM00491 (Cxpdneu3)
  9. SITE IPR002464
    DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
    1. PS00690 (DEAH_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...

Protein sequence

>MIA_02718_1
MKINIESLEVIFPYEKVYPEQVQYMTDIKRTLDVGGNCILEMPSGTGKTVSLLSITVAYQMSYPEHRKIIYCSRTMSEIE
KALAELRNLMAYRAKVLGYTEDFRGLGLTSRKNLCLNPDVRKERKGAVVDEKCRSLTNGISKTKLQAGDESAKLCEFHEN
LYNLEPHNLIPAGVYTFEDLINYCESIKTCPYFTVRRMMPYCNIIIYSYHYLLDPKIADRVSKELSKDAIVIFDEAHNID
NVCIESLSVDLTQDSLRKAARGAAALGRAVDDVKRTDASKLQHEYEKLVEGLQQAEADRAEDLFMSNPILPDDILKEAIP
GNIRRAEHFVAFLKRFIEYLKTRMRALHVISETPTSFLKHLKELTYIEKKPLGFATERLNSLVRTLELTDIEDFVSLKEI
VTFATLLATYEEGFVLILEPFETEGSTVPNPILHFSCLDASIAMKPVFERFSSVIITSGTISPLDMYPRMLNFDTVIQES
YSMTLSRRSFLPLIVTKGSDQVAISSRFEIRNDPSIVRNYGNLLIEFSKITPDGLVVFFPSYLYMESIISSWQAMGILDE
VWKYKLILVETPDSQETSLALETYRTACSNGRGAVMFSVARGKVSEGIDFDHHYGRAVLMIGLPFQYTESRILKARLEFL
RENFHIRENDFLSFDAMRHAAQCLGRVLRGKDDYGIMVLADRRFARKKSQLPKWIAQAILEGDVNLSTDMAVAASKKFLR
TLAQPADIEDQNGVSVWTQEQVEEFQQKNRGANAINVHPEPMDVS

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process
GO:0006289 nucleotide-excision repair

Molecular Function

GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Cellular Component

GO:0005634 nucleus