MCA_01687_1
Gene name: RAD3
Description: DNA repair helicase RAD3
Browser: contigA:5183929-5186233+
RNA-seq: read pairs 824, FPKM 13.3, percentile rank 31.3% (100% = highest expression)
Protein function
| Annotation: | RAD3 | DNA repair helicase RAD3 | |
|---|---|---|---|
| KEGG: | K10844 | ERCC2 | DNA excision repair protein ERCC-2 [EC:3.6.4.12] |
| EGGNOG: | 0PGIM | PGUG_04303 | dna repair helicase |
| SGD closest match: | S000000973 | RAD3 | DNA repair helicase RAD3 |
| CGD closest match: | CAL0000192893 | RAD3 | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02718_1 | 89.83% | 767 | 0.0 | MIA_02718_1 |
| A0A0J9XJA5_GEOCN | 80.73% | 768 | 0.0 | Similar to Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase OS=Geotrichum candidum GN=BN980_GECA23s00186g PE=4 SV=1 |
| A0A1E3PJI6_9ASCO | 79.71% | 749 | 0.0 | DNA repair helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50880 PE=4 SV=1 |
| A0A161HM58_9ASCO | 84.01% | 713 | 0.0 | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 OS=Sugiyamaella lignohabitans GN=RAD3 PE=4 SV=1 |
| A0A060TCL9_BLAAD | 79.50% | 766 | 0.0 | ARAD1D37136p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37136g PE=4 SV=1 |
| Q6C0Y5_YARLI | 78.95% | 746 | 0.0 | YALI0F20746p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20746g PE=4 SV=1 |
| A0A1D8PQH0_CANAL | 78.27% | 741 | 0.0 | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD3 PE=4 SV=1 |
| UniRef50_A0A099P606 | 77.13% | 739 | 0.0 | Uncharacterized protein n=2 Tax=Pichia kudriavzevii TaxID=4909 RepID=A0A099P606_PICKU |
| RAD3_YEAST | 75.17% | 749 | 0.0 | DNA repair helicase RAD3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD3 PE=1 SV=1 |
| A0A1E4TMC0_9ASCO | 74.92% | 622 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30908 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0207
Protein family membership
- DNA helicase (DNA repair), Rad3 type (IPR013020)
- RAD3/XPD family (IPR001945)
Domains and repeats
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Domain
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Domain
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Domain
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Domain
Detailed signature matches
no IPR
Protein sequence
>MCA_01687_1 MKINIDSLEVIFPYEKVYPEQVQYMTDIKKTLDVGGNCILEMPSGTGKTVSLLSITIAYQMAYPEHRKIIYCSRTMSEIE KALAELRHLMKYRAKVLGKVEEFRGLGLTSRKNLCLHPTVRKERKGAVVDEKCRSLTNGIAKSKLLAGDTTAQLCEYHEN LYNLEPHNLIPPGVYTFEDLIDYCEEHKTCPYFTVRRMMPFCNIIIYSYHYLLDPKIADRVSKELSKDSIVIFDEAHNID NVCIESLSVDLTNDSLKRAARGAAALGRAVDEVKRTDSEKLNREYQKLVEGLRESEAARAEDMFMGNPVLPEDVINEAIP GNIRRAEHFVSFLKRFIEYLKTRMKALHVISETPVSFLKHLKELTYIDKKPLGFATERLNSLVRTLELTDIEDFIYLKEI VTFATLLATYEEGFVLILEPFETENSKVPNPILHFSCLDASIAMKPVFERFSSVIITSGTISPLDMYPRMLNFDTVIQES YTMTLSRRSFLPLVVTKGSDQVAISSRFEIRNDPSIVRNYGNLLIEFSKITPDGLVVFFPSYLYMESIISSWQAMGILDE VWKYKLILVETPDSQETSLALETYRTACSNGRGAVMFSVARGKVSEGIDFDHHYGRAVLMIGVPFQYTESRILKARLEFL REHFHIRENDFLSFDAMRHAAQCLGRVLRGKDDYGIMVLADRRFARKRNQLPKWIAQAISEGDVNLSIDMAVAAAKKFLR TLAQPVNPEDQNGVSVWTEEQVIEFQHKNMSHLKNGNRNGLEPMDVS
GO term prediction
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006289 nucleotide-excision repair
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Cellular Component
GO:0005634 nucleus