MIA_02685_1

Protein

Length

663 amino acids

Protein function

EGGNOG:	0QDYF	PGUG_03366	transporter
SGD closest match:	S000003951	TPO1	Polyamine transporter 1
CGD closest match:	CAL0000199735	FLU1	Flu1p

Protein alignments

	%id	Aln length	E-value
A0A060T8G4_BLAAD	41.126%	462	6.56e-127	ARAD1C36806p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36806g PE=4 SV=1
A0A0J9XHB1_GEOCN	35.769%	520	3.51e-120	Similar to Saccharomyces cerevisiae YHR048W YHK8 Presumed antiporter of the DHA1 family of multidrug resistance transporters OS=Geotrichum candidum GN=BN980_GECA16s01781g PE=4 SV=1
Q6C2G6_YARLI	37.740%	469	2.27e-111	YALI0F08063p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F08063g PE=4 SV=1
UniRef50_O43081	35.628%	494	1.22e-107	Uncharacterized MFS-type transporter C947.06c n=31 Tax=Ascomycota TaxID=4890 RepID=YHS6_SCHPO
MCA_04129_1	37.021%	470	9.91e-106	MCA_04129_1
A0A167ETU3_9ASCO	35.113%	487	3.48e-108	Tpo1p OS=Sugiyamaella lignohabitans GN=TPO1 PE=4 SV=1
A0A1E3PN55_9ASCO	34.273%	461	5.51e-78	Putative MFS multidrug transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_73963 PE=4 SV=1
A0A1E4TAB0_9ASCO	31.197%	468	1.69e-75	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_127309 PE=4 SV=1
G1UB37_CANAL	31.915%	470	3.99e-68	Flu1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FLU1 PE=4 SV=1
TPO1_YEAST	32.903%	465	5.30e-67	Polyamine transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0264

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
209 - 653
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 600 663

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  230 - 608
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  225 - 653
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  209 - 651
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  226 - 646
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

513 - 532

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

647 - 663

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

279 - 289

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 224

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

338 - 348

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

586 - 596

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

400 - 446

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

218 - 415

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

446 - 660

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

473 - 491

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

372 - 376

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

555 - 559

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

309 - 313

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

620 - 624

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

248 - 258

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

376 - 398

TMHMM
TMhelix (TMhelix)

560 - 582

TMHMM
TMhelix (TMhelix)

225 - 247

TMHMM
TMhelix (TMhelix)

624 - 646

TMHMM
TMhelix (TMhelix)

489 - 511

TMHMM
TMhelix (TMhelix)

531 - 553

TMHMM
TMhelix (TMhelix)

347 - 369

TMHMM
TMhelix (TMhelix)

291 - 308

TMHMM
TMhelix (TMhelix)

259 - 281

TMHMM
TMhelix (TMhelix)

454 - 476

TMHMM
TMhelix (TMhelix)

315 - 337

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

447 - 472

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

225 - 247

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

377 - 399

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

492 - 512

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

314 - 337

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

290 - 308

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

625 - 646

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

533 - 554

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

349 - 371

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

597 - 619

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

259 - 278

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

560 - 585

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

127 - 156

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 43

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

240S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

243I

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

244A

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

245S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

247A

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

248T

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

265S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

268Y

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

269F

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

272M

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

276P

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

277L

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

279L

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

280A

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

326A

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

327S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

330I

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

331V

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

334G

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

335G

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

338S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

350L

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

351T

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

354S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

355L

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

361P

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

466F

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

469Y

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

470Y

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

473S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

474M

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

477P

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

491S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

499F

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

503N

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

506A

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

510L

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

571G

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

574F

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

575F

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

578L

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

582L

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

583N

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

586C

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

596C

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

597I

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

600N

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

601A

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

604R

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

605S

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

608A

putative substrate translocation pore
240S, 243I, 244A, 245S, 247A, 248T, 265S, 268Y, 269F, 272M, 276P, 277L, 279L, 280A, 326A, 327S, 330I, 331V, 334G, 335G, 338S, 350L, 351T, 354S, 355L, 361P, 466F, 469Y, 470Y, 473S, 474M, 477P, 491S, 499F, 503N, 506A, 510L, 571G, 574F, 575F, 578L, 582L, 583N, 586C, 596C, 597I, 600N, 601A, 604R, 605S, 608A
CDD
cd06174 (MFS)

Protein sequence

>MIA_02685_1
MSFFSKSFTPKKVKEEDLEGASKTGCSSSSESTQSTTAYEISEEEIKREPGIAGRCNKCFRRFFQNIGELLMENEEPPII
FPPPSKPSMVSIITHGHLHIKEHMEKIHNFQNDERCIINIIPTSTSPHPFDSKEVEETTISSPQTGTSSIISANSEKPLT
LNKRDRQLLLLKEYKRANDQNNTLFYKNANLIQKYISEPQFHVTFDPVNDPEYPRNWDWKIKIRGTLIFAVAAMLAQLGS
AVIASIATDLQKEFGVRSILTSLASTIYFLGMAFGPLFLAPLSELWGRKLAVAVPFALGSLVTILTGHARNFSVLLICRF
FAGLLASAPIVISGGAISDLWYPGQRATFLTINSLAIVLGPTTAYLYGTVIKKATSWRWAVCIHAFLSALIVLFIILGVR
ETYHPVLLQRKAKYLRLKTQNWLYHSDHDSLELNAKEIMRVHLLRPICLLSTPIVLVVCIFNGFSFGLYYMISMYVPKSF
QEERSWGAISSSLPPLAIFVGANCGAVIHLIVGGLNRRKLKKSMGECTPEARLLVPLLIGWFMPLGMIIFGWSMTENLHW
TVSCLGLMFVGAGFFVILQGSLNYLCDAFPKYSASCIAANAFMRSLFACGIPLVAPYLFEQLGLGWGATTLGFIGFLMTI
FVFYIFKYGAKIRTKESLLTHDC

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features