MCA_04129_1

Protein

Length

790 amino acids

RNA-seq: read pairs 339, FPKM 5.3, percentile rank 18.0% (100% = highest expression)

Protein function

EGGNOG:	0PFE6	PGUG_02435	MFS multidrug transporter
SGD closest match:	S000001090	YHK8	Probable drug/proton antiporter YHK8
CGD closest match:	CAL0000199735	FLU1	Flu1p

Protein alignments

	%id	Aln length	E-value
MIA_02685_1	37.02%	470	1e-94	MIA_02685_1
A0A0J9X3E2_GEOCN	29.84%	439	1e-59	Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily OS=Geotrichum candidum GN=BN980_GECA02s03612g PE=4 SV=1
UniRef50_A0A0J9X3E2	29.84%	439	3e-56	Similar to Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3E2_GEOCN
A0A060T8G4_BLAAD	29.25%	482	2e-60	ARAD1C36806p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36806g PE=4 SV=1
Q6C2G6_YARLI	28.81%	413	7e-54	YALI0F08063p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F08063g PE=4 SV=1
A0A167ETU3_9ASCO	27.29%	425	1e-51	Tpo1p OS=Sugiyamaella lignohabitans GN=TPO1 PE=4 SV=1
G1UB37_CANAL	28.41%	433	5e-44	Flu1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FLU1 PE=4 SV=1
A0A1E4TAB0_9ASCO	24.45%	458	3e-43	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_127309 PE=4 SV=1
A0A1E3PPH0_9ASCO	25.22%	456	2e-38	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81829 PE=4 SV=1
YHK8_YEAST	23.67%	431	1e-32	Probable drug/proton antiporter YHK8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YHK8 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4224

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
306 - 756
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 600 700 790

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  329 - 694
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  323 - 756
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  306 - 756
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  324 - 748
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

437 - 447

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

753 - 790

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

685 - 695

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

499 - 545

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 323

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

612 - 631

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

378 - 388

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

544 - 767

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

308 - 525

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

346 - 356

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

469 - 479

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

654 - 658

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

407 - 417

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

571 - 589

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

717 - 727

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

553 - 575

TMHMM
TMhelix (TMhelix)

630 - 652

TMHMM
TMhelix (TMhelix)

727 - 749

TMHMM
TMhelix (TMhelix)

588 - 610

TMHMM
TMhelix (TMhelix)

352 - 374

TMHMM
TMhelix (TMhelix)

384 - 406

TMHMM
TMhelix (TMhelix)

323 - 345

TMHMM
TMhelix (TMhelix)

479 - 498

TMHMM
TMhelix (TMhelix)

659 - 681

TMHMM
TMhelix (TMhelix)

413 - 435

TMHMM
TMhelix (TMhelix)

445 - 467

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

418 - 436

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

590 - 611

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

696 - 716

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

389 - 406

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

448 - 468

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

659 - 684

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

632 - 653

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

357 - 377

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

324 - 345

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

480 - 498

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

546 - 570

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

728 - 752

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

15 - 34

MobiDB Lite
mobidb-lite (disorder_prediction)

165 - 234

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

338C

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

341L

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

342S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

343P

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

345S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

346D

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

363S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

366Y

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

367F

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

370M

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

374P

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

375P

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

377M

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

378T

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

424A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

425S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

428I

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

429V

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

432G

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

433S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

436A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

448I

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

449A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

452S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

453M

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

459P

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

561N

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

564A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

565F

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

568Y

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

569I

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

572S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

586G

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

590S

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

594C

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

597V

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

601A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

670G

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

673F

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

674L

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

677L

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

681L

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

682N

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

685V

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

695C

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

696L

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

699N

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

700A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

703R

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

704A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

707A

putative substrate translocation pore
338C, 341L, 342S, 343P, 345S, 346D, 363S, 366Y, 367F, 370M, 374P, 375P, 377M, 378T, 424A, 425S, 428I, 429V, 432G, 433S, 436A, 448I, 449A, 452S, 453M, 459P, 561N, 564A, 565F, 568Y, 569I, 572S, 586G, 590S, 594C, 597V, 601A, 670G, 673F, 674L, 677L, 681L, 682N, 685V, 695C, 696L, 699N, 700A, 703R, 704A, 707A
CDD
cd06174 (MFS)

Protein sequence

>MCA_04129_1
MGFFKTSFTKFKVRRDENVEKKGEKPPQLTEEEQNEIDEIARFKKYSDLITESLEQIRDTAYKVETDTEKSGASDLYYNP
INATDPSGFEVFRVSEEPPMFERPKFNRPVCVPILNHGMLHIPEARKLHCRHLIEAYQQFVHLEAGRRSFIKRRNSAQSL
LLLKNSTESSTSSSDNNDQQNTTPPSPEGTTVFNSLETSSFENSSSNKNSTDSSPSSSPSSSSSPSSSSSTIETDSHDEI
CCRLVQLGKDLNMFGLKLGLDHHDLMAVPELTNTTEDLTTVSQKRLVNEAIVHYLTDDRFIVLMDSLDPDNPRNWKTAQK
IKNVVAYALVCMIAQLGCGMLSPASDQIIKLYNISPLIAPFVSSVYFLGMALGPPMMTPLADLIGRARVTMIAFCFGVLV
TTAASGSKYFSLLIAWRFIYGVCASAPIVLAGSSIADSYQKHVRGIAIAFNSMSIVFGPACSCLFGSLILKSNFSWEDIL
HFYAVVCLVTAIIFYTMVKESNPKVILRKKASFLRKLTGNNMYRSEWDIEQLSFWGIMIKYFKEPLCILGEPVVLIMCLY
NGFAFGLYIMFSISVFNSFRIHYNWGILESCWPCLSVAIGAVIGGIIHLLLGQWYLKMKVAKTGEYTPEYRLMTPSVMSW
LMTVGMLTFGYSVEREFHWVWACTGLVFLGMGFLTILQGSLNYLVDAFPQKSSACLSCNAMIRALFACCMPIFSTVVFKK
KEALKKGFFPLASTSFVLSIALAAVFCFGKVMRKSKKLQPKKSDFDEGHISTSVIDTVNLLYNFEERRRV

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features