MIA_02671_1

Protein

Length

1,970 amino acids

Browser: contig03:1416116-1422096-

Protein function

EGGNOG:	0PGAG	PGUG_03037	helicase
SGD closest match:	S000003503	SLH1	Antiviral helicase SLH1
CGD closest match:	CAL0000181614	orf19.3980	Putative RNA helicase

Protein alignments

	%id	Aln length
MCA_04113_1	77.102%	1974	MCA_04113_1
A0A0J9X2V6_GEOCN	71.726%	1970	Similar to Saccharomyces cerevisiae YGR271W SLH1 Putative RNA helicase related to Ski2p OS=Geotrichum candidum GN=BN980_GECA01s10933g PE=4 SV=1
A0A1E3PN07_9ASCO	62.714%	1982	Sec63-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69756 PE=4 SV=1
A0A060T9Q3_BLAAD	63.958%	1895	ARAD1C39490p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C39490g PE=4 SV=1
A0A1D8PP41_CANAL	61.220%	1885	Putative RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3980 PE=4 SV=1
A0A161HGG1_9ASCO	67.002%	1688	Slh1p OS=Sugiyamaella lignohabitans GN=SLH1 PE=4 SV=1
Q6CEQ3_YARLI	60.804%	1865	YALI0B13904p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13904g PE=4 SV=1
UniRef50_A0A0H5C072	58.676%	1873	Uncharacterized protein n=1 Tax=Cyberlindnera jadinii TaxID=4903 RepID=A0A0H5C072_CYBJA
SLH1_YEAST	58.249%	1885	Antiviral helicase SLH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLH1 PE=1 SV=2
A0A1E4TK99_9ASCO	42.427%	1895	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30350 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0615

Protein family membership

None predicted.

Domains and repeats

Domain
210 - 510
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
AAA+ ATPase domain (IPR003593)
471 - 685
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,016 - 1,521
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
AAA+ ATPase domain (IPR003593)
1,848 - 1,968
Immunoglobulin E-set (IPR014756)
Domain
266 - 483
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
DEAD/DEAH box helicase domain (IPR011545)
507 - 702
Helicase, C-terminal (IPR001650)
778 - 1,083
Sec63 domain (IPR004179)
1,121 - 1,321
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
DEAD/DEAH box helicase domain (IPR011545)
1,340 - 1,551
Helicase, C-terminal (IPR001650)
1,610 - 1,968
Sec63 domain (IPR004179)
Domain
978 - 1,086
C2 domain (IPR000008)
1,521 - 1,622
Winged helix-turn-helix DNA-binding domain (IPR011991)
1,833 - 1,970
C2 domain (IPR000008)

1 200 400 600 800 1000 1200 1400 1600 1800 1970

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  210 - 461
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,016 - 1,309
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  471 - 685
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,311 - 1,521
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  279 - 468
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
  
  1,134 - 1,309
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  1,121 - 1,321
  
  SMART
  SM00487 (ultradead3)
  
  266 - 483
  
  SMART
  SM00487 (ultradead3)
IPR011545

DEAD/DEAH box helicase domain
1. PF00270 (DEAD)
  
  272 - 452
  
  Pfam
  PF00270 (DEAD)
  
  1,127 - 1,289
  
  Pfam
  PF00270 (DEAD)
IPR003593

AAA+ ATPase domain
1. SM00382 (AAA_5)
  
  1,139 - 1,381
  
  SMART
  SM00382 (AAA_5)
  
  284 - 510
  
  SMART
  SM00382 (AAA_5)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  514 - 702
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
  
  1,340 - 1,551
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  1,401 - 1,493
  
  SMART
  SM00490 (helicmild6)
  
  569 - 657
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  1,406 - 1,491
  
  Pfam
  PF00271 (Helicase_C)
  
  507 - 655
  
  Pfam
  PF00271 (Helicase_C)
IPR004179

Sec63 domain
1. PF02889 (Sec63)
  
  779 - 1,081
  
  Pfam
  PF02889 (Sec63)
  
  1,610 - 1,934
  
  Pfam
  PF02889 (Sec63)
2. SM00973 (Sec63_2)
  
  1,610 - 1,968
  
  SMART
  SM00973 (Sec63_2)
  
  778 - 1,083
  
  SMART
  SM00973 (Sec63_2)
IPR000008

C2 domain
1. G3DSA:2.60.40...
  
  1,833 - 1,970
  
  GENE3D
  G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
  
  978 - 1,086
  
  GENE3D
  G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
IPR011991

Winged helix-turn-helix DNA-binding domain
1. SSF46785 ("Winged h...)
  
  1,521 - 1,622
  
  SUPERFAMILY
  SSF46785 ("Winged helix" DNA-binding domain)
IPR014756

Immunoglobulin E-set
1. SSF81296 (E set dom...)
  
  1,848 - 1,968
  
  SUPERFAMILY
  SSF81296 (E set domains)

no IPR

Unintegrated signatures

Coil

154 - 188

COILS
Coil (Coil)
G3DSA:1.10.33...

1,638 - 1,757

GENE3D
G3DSA:1.10.3380.10 (G3DSA:1.10.3380.10)

806 - 923

GENE3D
G3DSA:1.10.3380.10 (G3DSA:1.10.3380.10)
G3DSA:3.40.50...

139 - 466

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

480 - 703

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

1,339 - 1,524

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

1,088 - 1,316

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PIRSF039073 (BRR2)

15 - 1,928

PIRSF
PIRSF039073 (BRR2)
SSF158702 (Sec63 N-...)

807 - 979

SUPERFAMILY
SSF158702 (Sec63 N-terminal domain-like)

1,639 - 1,772

SUPERFAMILY
SSF158702 (Sec63 N-terminal domain-like)
cd00046 (DEXDc)

1,142 - 1,288

CDD
cd00046 (DEXDc)

286 - 450

CDD
cd00046 (DEXDc)
cd00079 (HELICc)

1,410 - 1,503

CDD
cd00079 (HELICc)

505 - 655

CDD
cd00079 (HELICc)
mobidb-lite (disord...)

1,908 - 1,928

MobiDB Lite
mobidb-lite (disorder_prediction)

57 - 81

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

295G

ATP binding site
295G, 296A, 297G, 298K, 299T
CDD
cd00046 (DEXDc)

296A

ATP binding site
295G, 296A, 297G, 298K, 299T
CDD
cd00046 (DEXDc)

297G

ATP binding site
295G, 296A, 297G, 298K, 299T
CDD
cd00046 (DEXDc)

298K

ATP binding site
295G, 296A, 297G, 298K, 299T
CDD
cd00046 (DEXDc)

299T

ATP binding site
295G, 296A, 297G, 298K, 299T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

410D

putative Mg++ binding site
410D, 411E, 412V, 413H
CDD
cd00046 (DEXDc)

411E

putative Mg++ binding site
410D, 411E, 412V, 413H
CDD
cd00046 (DEXDc)

412V

putative Mg++ binding site
410D, 411E, 412V, 413H
CDD
cd00046 (DEXDc)

413H

putative Mg++ binding site
410D, 411E, 412V, 413H
CDD
cd00046 (DEXDc)
nucleotide binding...

523H

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

524S

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

525R

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

526K

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

583H

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

584A

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

609T

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

610A

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)

611T

nucleotide binding region
523H, 524S, 525R, 526K, 583H, 584A, 609T, 610A, 611T
CDD
cd00079 (HELICc)
ATP-binding site c...

617N

ATP-binding site
617N, 648Q, 652R, 655R
CDD
cd00079 (HELICc)

648Q

ATP-binding site
617N, 648Q, 652R, 655R
CDD
cd00079 (HELICc)

652R

ATP-binding site
617N, 648Q, 652R, 655R
CDD
cd00079 (HELICc)

655R

ATP-binding site
617N, 648Q, 652R, 655R
CDD
cd00079 (HELICc)
ATP binding site c...

1,150G

ATP binding site
1,150G, 1,151S, 1,152G, 1,153K, 1,154T
CDD
cd00046 (DEXDc)

1,151S

ATP binding site
1,150G, 1,151S, 1,152G, 1,153K, 1,154T
CDD
cd00046 (DEXDc)

1,152G

ATP binding site
1,150G, 1,151S, 1,152G, 1,153K, 1,154T
CDD
cd00046 (DEXDc)

1,153K

ATP binding site
1,150G, 1,151S, 1,152G, 1,153K, 1,154T
CDD
cd00046 (DEXDc)

1,154T

ATP binding site
1,150G, 1,151S, 1,152G, 1,153K, 1,154T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

1,251D

putative Mg++ binding site
1,251D, 1,252E, 1,253I, 1,254H
CDD
cd00046 (DEXDc)

1,252E

putative Mg++ binding site
1,251D, 1,252E, 1,253I, 1,254H
CDD
cd00046 (DEXDc)

1,253I

putative Mg++ binding site
1,251D, 1,252E, 1,253I, 1,254H
CDD
cd00046 (DEXDc)

1,254H

putative Mg++ binding site
1,251D, 1,252E, 1,253I, 1,254H
CDD
cd00046 (DEXDc)
nucleotide binding...

1,419H

nucleotide binding region
1,419H, 1,420A, 1,445T, 1,446S, 1,447T
CDD
cd00079 (HELICc)

1,420A

nucleotide binding region
1,419H, 1,420A, 1,445T, 1,446S, 1,447T
CDD
cd00079 (HELICc)

1,445T

nucleotide binding region
1,419H, 1,420A, 1,445T, 1,446S, 1,447T
CDD
cd00079 (HELICc)

1,446S

nucleotide binding region
1,419H, 1,420A, 1,445T, 1,446S, 1,447T
CDD
cd00079 (HELICc)

1,447T

nucleotide binding region
1,419H, 1,420A, 1,445T, 1,446S, 1,447T
CDD
cd00079 (HELICc)
ATP-binding site c...

1,453N

ATP-binding site
1,453N, 1,484Q, 1,488R, 1,491R
CDD
cd00079 (HELICc)

1,484Q

ATP-binding site
1,453N, 1,484Q, 1,488R, 1,491R
CDD
cd00079 (HELICc)

1,488R

ATP-binding site
1,453N, 1,484Q, 1,488R, 1,491R
CDD
cd00079 (HELICc)

1,491R

ATP-binding site
1,453N, 1,484Q, 1,488R, 1,491R
CDD
cd00079 (HELICc)

Protein sequence

>MIA_02671_1
MVPQDPIHSFDSFLDSVTRMQDAVSKFQLETSELPEDFSVLDKDLIKNSDIDQLTIFNDSSSSSDTESSDEETQQGSKIQ
DTNLEWLTSQLSRTSLTTSMNENEMYTTVLSILTSDSPDEELQSSLPDILGYDHLELVIELISRRKEIQQSSRIQELEKE
TNYHLMTVEEIEQQRMQNQRETQRLNSNLQLAPASVKYPHVYKRDTGGSILNAFGSKYSLPAGTTRTVEPKYEEVIIPAS
SKKPLVEPRLIPIKELDKLCQGTFKKYKTLNRMQSLVYPIGYETNENMLVCAPTGAGKTDVALLTMLSTINQYSIFDTAT
QSYTVDLSNFKIVYVAPLKALAAEVVEKMSQRLSWVGISVRELTGDMQLTRSEIISTQIIVTTPEKWDVVTRKSTGDNEL
VSKVRLLIIDEVHLLHEDRGAVIESLVARTLRQVESTQSMVRIVGLSATLPNYLDVAEFLRVNPMAGLFFFDDSFRPVPL
EQQFLAIRAKAGTKQARDEIDRISYEKLVEMLNEGHQIMVFVHSRKDTINTARSYISQAQKMHDTYLFDCSTNESYNSFE
KEMSKWKNRDMKELFMGGFGIHHAGMLRSERNLTEKMFLNGAIKVLCCTATLAWGVNLPAAVVMIKGTQVYDAKRGGFVD
LSITDVIQIFGRAGRPQFEQVGIGILCTTSDRLSHYLSAITQQHPIESKLTTKIEDNLNAEIALGTVTSIDEGVQWLGYT
YLFVRMRKNPLAYGLGWEDVSEDPLLGQRRRKLIVDAARKLHLLQMIVYDDVTGTFISKDTGRVASDFYLLNSSVEVFNK
LMNPAATEADVFSMISMSSEFDGIKAREEEGKELKSLLEESSPCQVLGDFDSPQGKTNILLQAYISNASIKDSALISDAA
YVAQNSTRICRALFLLALNRRWGRLANLLLSLCKSVENRLWSFEHPLAQFDLPQQVLRNLESSGAQISDLRDMEIGEIGQ
LIHNQRSASLVARYLDRFPTLHIESEIAPLTKSVLKIKITLEPEFIWDSRIHGNAQFFWVWVEESDDFKLLHYEKFILSR
QKLDNPHLLDFTVPLADPLPSQIVIRVVSDTWAGAESSMPVSFQHLIRPEAESVSTKLLPLRPLPITALDNKAIEGIYSP
KFRFFNPMQTMIFHPIYNSNTNVLLGSPTGSGKTVAAELAIWWAFKTYPKSKVVYIAPMKALVRERVDDWNSRITKPLNL
KLVELTGDSTPDSSTIKNADIIITTPEKFDGISRNWQSRKFVQEVSLIIMDEIHLLASDRGPILEMIVSRMNFVSAKTAR
PVRLLGLSSAIANAYDMASWLKVRDEGLFNFPSTVRPVPLEMYIDGFPDNMGFCPLMKSMNKPAFLAIKKHSPTKPVLIF
VASRRQTRLTALDLIHMLGMEDNPRRFLSMDEDELQEAISVAVDDTLKLSLQFGIGLHHAGLVDTDRRLSHELFANNKIQ
ILVATSTLAWGVNLPAYLVVIKGTQFFDAKIEAYKDMDLTDVLQMMGRAGRPAFDTSGVAVVFTKESTKPFYKYFLNSGF
PVESSLHKVLTDHLGAEITSRTIKTRQEALDFLTWTFLFRRIHYNPTYYGIEDATEDGINKWLINLVDKSISNLHEAGCL
QNTQDGKLAPTEFLNISSYYYLSHKTMHTFLKHMHRKPNFKDCLQWLCLASEYDELPVRHNEDLVNIEMSQEMRFPGEEM
NLIMWDPHVKSYLLLQAYMSRVDLPITDYIQDTTTVLDQALRILQAAVDTATVLGYLSTVLTLISVMQCLKQGYWFDDDP
VSALPGLSLKPLPASHPMRENETGTALLRMPIPDDKSRVTTLKDFANAKGQVLENLMSKIGVLKSKRNEFSRIATSLPIV
DVVTKYDSAQGVLSVVLTHRNSSILSNDFKVYAPKFHKVQKESWFIIVGDTEKDELIALTRGSPRAYTGADKNKSTANTV
NQKKGRSQGRDVKIEASLNIPKGNKGGRLMLYCVSDALDIRYEMEVSVHS

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_02671_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component