MCA_04113_1

Protein

Length

1,980 amino acids

Gene name: SLH1

Description: Antiviral helicase SLH1

Browser: contigC:2088452-2094547-

RNA-seq: read pairs 2524, FPKM 15.7, percentile rank 35.2% (100% = highest expression)

Protein function

Annotation:		SLH1	Antiviral helicase SLH1
KEGG:	K18664	SLH1	antiviral helicase SLH1 [EC:3.6.4.13]
EGGNOG:	0PGAG	PGUG_03037	helicase
SGD closest match:	S000003503	SLH1	Antiviral helicase SLH1
CGD closest match:	CAL0000181614	orf19.3980	Putative RNA helicase

Protein alignments

	%id	Aln length
MIA_02671_1	77.10%	1974	MIA_02671_1
A0A0J9X2V6_GEOCN	70.24%	1979	Similar to Saccharomyces cerevisiae YGR271W SLH1 Putative RNA helicase related to Ski2p OS=Geotrichum candidum GN=BN980_GECA01s10933g PE=4 SV=1
A0A1E3PN07_9ASCO	64.26%	1908	Sec63-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69756 PE=4 SV=1
A0A060T9Q3_BLAAD	63.22%	1887	ARAD1C39490p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C39490g PE=4 SV=1
A0A1D8PP41_CANAL	59.50%	1906	Putative RNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3980 PE=4 SV=1
A0A161HGG1_9ASCO	65.07%	1749	Slh1p OS=Sugiyamaella lignohabitans GN=SLH1 PE=4 SV=1
Q6CEQ3_YARLI	58.84%	1939	YALI0B13904p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13904g PE=4 SV=1
UniRef50_A0A0H5C072	58.51%	1892	Uncharacterized protein n=1 Tax=Cyberlindnera jadinii TaxID=4903 RepID=A0A0H5C072_CYBJA
SLH1_YEAST	57.16%	1893	Antiviral helicase SLH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLH1 PE=1 SV=2
A0A1E4TK99_9ASCO	43.75%	1847	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30350 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1984

Protein family membership

None predicted.

Domains and repeats

Domain
265 - 482
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
DEAD/DEAH box helicase domain (IPR011545)
977 - 1,085
C2 domain (IPR000008)
1,120 - 1,320
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
DEAD/DEAH box helicase domain (IPR011545)
1,520 - 1,621
Winged helix-turn-helix DNA-binding domain (IPR011991)
1,831 - 1,971
C2 domain (IPR000008)
Domain
277 - 536
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
AAA+ ATPase domain (IPR003593)
574 - 670
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,006 - 1,520
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
AAA+ ATPase domain (IPR003593)
1,837 - 1,904
Immunoglobulin E-set (IPR014756)
1,931 - 1,966
Immunoglobulin E-set (IPR014756)
Domain
503 - 701
Helicase, C-terminal (IPR001650)
777 - 1,082
Sec63 domain (IPR004179)
1,339 - 1,550
Helicase, C-terminal (IPR001650)
1,609 - 1,969
Sec63 domain (IPR004179)

1 200 400 600 800 1000 1200 1400 1600 1800 1980

Detailed signature matches

IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  278 - 467
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
  
  1,133 - 1,308
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  265 - 482
  
  SMART
  SM00487 (ultradead3)
  
  1,120 - 1,320
  
  SMART
  SM00487 (ultradead3)
IPR011545

DEAD/DEAH box helicase domain
1. PF00270 (DEAD)
  
  272 - 451
  
  Pfam
  PF00270 (DEAD)
  
  1,126 - 1,288
  
  Pfam
  PF00270 (DEAD)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,310 - 1,520
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,006 - 1,308
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  574 - 670
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  277 - 536
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003593

AAA+ ATPase domain
1. SM00382 (AAA_5)
  
  283 - 474
  
  SMART
  SM00382 (AAA_5)
  
  1,138 - 1,372
  
  SMART
  SM00382 (AAA_5)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  503 - 701
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
  
  1,339 - 1,550
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  1,404 - 1,492
  
  SMART
  SM00490 (helicmild6)
  
  564 - 656
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  1,403 - 1,490
  
  Pfam
  PF00271 (Helicase_C)
  
  512 - 654
  
  Pfam
  PF00271 (Helicase_C)
IPR004179

Sec63 domain
1. PF02889 (Sec63)
  
  1,609 - 1,957
  
  Pfam
  PF02889 (Sec63)
  
  778 - 1,080
  
  Pfam
  PF02889 (Sec63)
2. SM00973 (Sec63_2)
  
  1,609 - 1,969
  
  SMART
  SM00973 (Sec63_2)
  
  777 - 1,082
  
  SMART
  SM00973 (Sec63_2)
IPR000008

C2 domain
1. G3DSA:2.60.40...
  
  977 - 1,085
  
  GENE3D
  G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
  
  1,831 - 1,971
  
  GENE3D
  G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
IPR011991

Winged helix-turn-helix DNA-binding domain
1. SSF46785 ("Winged h...)
  
  1,520 - 1,621
  
  SUPERFAMILY
  SSF46785 ("Winged helix" DNA-binding domain)
IPR014756

Immunoglobulin E-set
1. SSF81296 (E set dom...)
  
  1,837 - 1,904
  
  SUPERFAMILY
  SSF81296 (E set domains)
  
  1,931 - 1,966
  
  SUPERFAMILY
  SSF81296 (E set domains)

no IPR

Unintegrated signatures

G3DSA:1.10.33...

1,637 - 1,756

GENE3D
G3DSA:1.10.3380.10 (G3DSA:1.10.3380.10)

805 - 922

GENE3D
G3DSA:1.10.3380.10 (G3DSA:1.10.3380.10)
G3DSA:3.40.50...

1,087 - 1,315

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

1,340 - 1,522

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

245 - 475

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

480 - 702

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PIRSF039073 (BRR2)

45 - 1,937

PIRSF
PIRSF039073 (BRR2)
SSF158702 (Sec63 N-...)

1,638 - 1,828

SUPERFAMILY
SSF158702 (Sec63 N-terminal domain-like)

806 - 978

SUPERFAMILY
SSF158702 (Sec63 N-terminal domain-like)
cd00046 (DEXDc)

1,141 - 1,287

CDD
cd00046 (DEXDc)

285 - 449

CDD
cd00046 (DEXDc)
cd00079 (HELICc)

1,399 - 1,502

CDD
cd00079 (HELICc)

504 - 665

CDD
cd00079 (HELICc)
mobidb-lite (disord...)

1,909 - 1,931

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

294G

ATP binding site
294G, 295A, 296G, 297K, 298T
CDD
cd00046 (DEXDc)

295A

ATP binding site
294G, 295A, 296G, 297K, 298T
CDD
cd00046 (DEXDc)

296G

ATP binding site
294G, 295A, 296G, 297K, 298T
CDD
cd00046 (DEXDc)

297K

ATP binding site
294G, 295A, 296G, 297K, 298T
CDD
cd00046 (DEXDc)

298T

ATP binding site
294G, 295A, 296G, 297K, 298T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

409D

putative Mg++ binding site
409D, 410E, 411V, 412H
CDD
cd00046 (DEXDc)

410E

putative Mg++ binding site
409D, 410E, 411V, 412H
CDD
cd00046 (DEXDc)

411V

putative Mg++ binding site
409D, 410E, 411V, 412H
CDD
cd00046 (DEXDc)

412H

putative Mg++ binding site
409D, 410E, 411V, 412H
CDD
cd00046 (DEXDc)
nucleotide binding...

522H

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

523S

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

524R

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

525K

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

582H

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

583A

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

608T

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

609A

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)

610T

nucleotide binding region
522H, 523S, 524R, 525K, 582H, 583A, 608T, 609A, 610T
CDD
cd00079 (HELICc)
ATP-binding site c...

616N

ATP-binding site
616N, 647Q, 651R, 654R
CDD
cd00079 (HELICc)

647Q

ATP-binding site
616N, 647Q, 651R, 654R
CDD
cd00079 (HELICc)

651R

ATP-binding site
616N, 647Q, 651R, 654R
CDD
cd00079 (HELICc)

654R

ATP-binding site
616N, 647Q, 651R, 654R
CDD
cd00079 (HELICc)
ATP binding site c...

1,149G

ATP binding site
1,149G, 1,150S, 1,151G, 1,152K, 1,153T
CDD
cd00046 (DEXDc)

1,150S

ATP binding site
1,149G, 1,150S, 1,151G, 1,152K, 1,153T
CDD
cd00046 (DEXDc)

1,151G

ATP binding site
1,149G, 1,150S, 1,151G, 1,152K, 1,153T
CDD
cd00046 (DEXDc)

1,152K

ATP binding site
1,149G, 1,150S, 1,151G, 1,152K, 1,153T
CDD
cd00046 (DEXDc)

1,153T

ATP binding site
1,149G, 1,150S, 1,151G, 1,152K, 1,153T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

1,250D

putative Mg++ binding site
1,250D, 1,251E, 1,252I, 1,253H
CDD
cd00046 (DEXDc)

1,251E

putative Mg++ binding site
1,250D, 1,251E, 1,252I, 1,253H
CDD
cd00046 (DEXDc)

1,252I

putative Mg++ binding site
1,250D, 1,251E, 1,252I, 1,253H
CDD
cd00046 (DEXDc)

1,253H

putative Mg++ binding site
1,250D, 1,251E, 1,252I, 1,253H
CDD
cd00046 (DEXDc)
nucleotide binding...

1,399S

nucleotide binding region
1,399S, 1,418H, 1,419A, 1,444T, 1,445S, 1,446T
CDD
cd00079 (HELICc)

1,418H

nucleotide binding region
1,399S, 1,418H, 1,419A, 1,444T, 1,445S, 1,446T
CDD
cd00079 (HELICc)

1,419A

nucleotide binding region
1,399S, 1,418H, 1,419A, 1,444T, 1,445S, 1,446T
CDD
cd00079 (HELICc)

1,444T

nucleotide binding region
1,399S, 1,418H, 1,419A, 1,444T, 1,445S, 1,446T
CDD
cd00079 (HELICc)

1,445S

nucleotide binding region
1,399S, 1,418H, 1,419A, 1,444T, 1,445S, 1,446T
CDD
cd00079 (HELICc)

1,446T

nucleotide binding region
1,399S, 1,418H, 1,419A, 1,444T, 1,445S, 1,446T
CDD
cd00079 (HELICc)
ATP-binding site c...

1,452N

ATP-binding site
1,452N, 1,483Q, 1,487R, 1,490R
CDD
cd00079 (HELICc)

1,483Q

ATP-binding site
1,452N, 1,483Q, 1,487R, 1,490R
CDD
cd00079 (HELICc)

1,487R

ATP-binding site
1,452N, 1,483Q, 1,487R, 1,490R
CDD
cd00079 (HELICc)

1,490R

ATP-binding site
1,452N, 1,483Q, 1,487R, 1,490R
CDD
cd00079 (HELICc)

Protein sequence

>MCA_04113_1
MASDNQIKSFDSFLDSVMHMQDDLVGFEIKKSPASPLNLDSDVLKASLLEHFEFSSSSDDSDVSDDSCDTLDENHALSSS
QELQWLRSQLNQVASQSSMTTDELYSTVLGIVTSESSDDDLQSTLPEIIGYEHLDLIIEIISRRQSLIDSNEIYELEKKS
NYRLMGAEDIETQRILNQQETERRNKNLKFGVANINYPHVFKASNGGSVLSAFGTKYSLPAGTTRRTLHKYEEVVIPAST
KKPLVNPRLIPIPELDQLCQGTFKKYTSLNLMQSLVFPVGYETHENMLVCAPTGAGKTDVALLTMLSAIRQHSSFNKDTG
KYEVNLADFKIVYVAPLKALAAEVVEKMSSRLSWLGITVKELTGDMQLTRAEIMSTQVIVTTPEKWDVVTRKSTGDNELV
NKVRLLIIDEVHLLHEERGAVIESLVARTLRQVESSQSMVRIVGLSATLPNYLDVAEFLRVNPMSGLFFFDDSFRPVPLE
QQFIGVRGKAGSRQAMKDLDDISYDKLIEMLSLGHQIMVFVHSRKDTIKTARTYISMAQKMADEYIFDCSDNPTYERHSR
EMAKWKNRDMKELFQHGFGIHHAGMTRSERNLTEKLFLEGTIKVLCCTATLAWGVNLPAAVVMIKGTQVYDAKRGGFVDL
SITDVIQIFGRAGRPQFEQVGTGILCTTSDRLSHYLSAITQQHPIESKLNTKLEDNLNAEIALGTVTSVDEGVQWLGYTY
LFVRMRKNPFAYGIGWEEVAEDPLLGERRRKLIIDAARKLHLLQMIIYDDVTGTFLSKDNGRIASDYYLLNSSIEVFNRL
LDPNATEADIFSMISMSGEFDGIKAREEEVVELKRLLEERCPCEVLGASDSAQGKTNILLQAYISNASINESALISDAAY
VAQNSTRICRALFLIALNRRWGRLAGLLLATCKAIEKRLWTFEHPLAQFDLPQGVLKNLESKDVQISDLREMEVGEIGEL
VHNRKAGPLIARYLDRFPTLHIESEIAPLTKSVLKIRISLEPEFLWDYKIHGNAEFFWIWVEDSDEFRILHYEKFILNKQ
KLENPHILDFTVPLADPMPSQIVIRALSDTWAGAESSVAVSFQHLIRPESETISTKLLPLRPLPIKALDNLAIESIYSPK
FNFFNPMQTMIFNPIYYQNTNILLGSPTGSGKTVAAELAMWWAFRTYPKSKVVYIAPMKALVRERVDDWNARITKPLNLK
LVELTGDSTPDSQSIKNADIIITTPEKFDGISRNWQSRKFVQEISLIIMDEIHLLASERGPILEMIVSRMNFVSAKTARP
VRLLGLSSAIANAYDMASWLKVKDEGLFNFPSTVRPVPLEMYIDGFPDNLGFCPLMKAMNKPAFFAIKKHSPNKPVLIFV
ASRRQTRLTALDLIHLLGMEDNPRRFLKMEEDELQGALSMAKDETLKLSLQFGIGLHHAGLVDTDRKLSHQLFANNKIQI
LIATSTLAWGVNLPAYLVIIKGTQFFDAKIEAYKDMDLTDVLQMMGRAGRPAFDTSGVAMVFTKESTKPFYKYFLNSGFP
VESSLHKVLDDHLGAEITARTIKSRQDALDFLTWTFLFRRIHYNPTYYGIEDVTDSGINKWLVDLVDTSIKNLFESGCLI
NVQGDRLAPTKYLNISSYYYLSHKTMRKFLNNMCKKPTFSQCLQWLCLATEYDELPVRHNEDLVNIEMSREMRFPGEEMN
LIMWDPHVKSYLLLQAFMSRVELPITDYIQDTTTVLDQALRILQAAVDTATTLGYLSTTLTLISVMQCLKQACWFDDDPI
TVLPGMKVKPLPSSHPTKLNDSGTSPLRIPIPEDKTRVTTLKDLGNARGNELDNIMNKLGVAKEKQREFARIASALPVVD
IEATYNVETDSVEVTLTHKNSNVLSKDFKMYTPKYPKVQKESWFVILGNTQNDELIALTRCAPKVSKAAQEEKSLKTDTK
GKGKSRYSNQSRIKMSTTLKVPDNYRENSLMVYCINDAMDIRYEMEIPIQSGLDFGKEKK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_04113_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component