Protein

MIA_02659_1

Length
558 amino acids

Browser: contig03:1373961-1375638-

Protein function

EGGNOG:0PFFHBNA4Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
SGD closest match:S000000194BNA4Kynurenine 3-monooxygenase
CGD closest match:CAL0000200704BNA4Kynurenine 3-monooxygenase

Protein alignments

%idAln lengthE-value
MCA_05507_170.468%4910.0MCA_05507_1
A0A0J9XJC8_GEOCN62.451%5140.0Kynurenine 3-monooxygenase OS=Geotrichum candidum GN=BNA4 PE=3 SV=1
A0A1E3PNF7_9ASCO54.767%4516.07e-176Kynurenine 3-monooxygenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=BNA4 PE=3 SV=1
A0A161HI12_9ASCO52.667%4501.66e-163Kynurenine 3-monooxygenase OS=Sugiyamaella lignohabitans GN=BNA4 PE=3 SV=1
UniRef50_A0A161HI1252.667%4504.57e-160Kynurenine 3-monooxygenase n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A161HI12_9ASCO
A0A060T854_BLAAD54.098%4271.49e-159Kynurenine 3-monooxygenase OS=Blastobotrys adeninivorans GN=BNA4 PE=3 SV=1
KMO_YARLI51.389%4325.25e-152Kynurenine 3-monooxygenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=BNA4 PE=3 SV=1
KMO_CANAL52.796%4477.77e-152Kynurenine 3-monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BNA4 PE=3 SV=1
KMO_YEAST48.260%4312.10e-128Kynurenine 3-monooxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BNA4 PE=1 SV=1
A0A1E4TFI4_9ASCO52.669%2814.11e-92Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31448 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0183

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 558

Detailed signature matches

  1. Family IPR027545
    Kynurenine 3-monooxygenase
    1. MF_01971 (Kynurenin...)
  2. Domain IPR023753
    FAD/NAD(P)-binding domain
    1. G3DSA:3.50.50.60
    2. SSF51905 (FAD/NAD(P...)
  3. Domain IPR002938
    FAD-binding domain
    1. PF01494 (FAD_binding_3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. PR00420 (RNGMNOXGNASE)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)
  6. mobidb-lite (disord...)

Protein sequence

>MIA_02659_1
MSSSGSTHLGEDIVMVDSIHYNGSEPQTPSTGSVHSSASTENQQKRATSEDKPAPVAQEQPAKPSAPLKLYSPIPRDKQL
PPREIKTIAVVGAGLVGCVAALAFQRKGYNVRVFEGRPDARTPEQREIFSYRSINMAVSARGILTLDSIDQDMSDRVLKN
LIPMYGRMIHDLAGEEISQKYGLYGESINSIDRADLNRGLLDELDRSNIQTFFNHKLVHASLEPKTKLTFTVDSEFPDGP
QKTAVFDDIDLVIGADGAHSKVRAQLGKYVRLDFSQEYIDSAYVELRIEPNKPTSDDDPVSFYKMDQTFKLDKNHLHIWP
RHNYMLIALPNTDGSFTSTLFAPWSLLESLDTEEKWFDFFWSNFPDVFEKSLMTKDSLLRAYHENPRGSLVCVRCTPYNY
QDKAIIIGDAAHSMVPFYGQGMNCGFEDVRVLMELLDKHNFSFKKAFDEYTATRNKDLNAIVDLAMQNYIEMRHSVISMS
FLLRKKLDNFLSKTFGNHWLPLYTMVTFRPDIPYSEALRRETLQAKIVHNIVYYATGLFALAGAATVFRLIRKLKFFS

GO term prediction

Biological Process

GO:0006569 tryptophan catabolic process
GO:0019805 quinolinate biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004502 kynurenine 3-monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding

Cellular Component

None predicted.